WormBase Tree Display for Gene: WBGene00004719

WBGene00004719 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F15A2
  Identity: Version: 1
    Name: CGC_name: sad-1 Person_evidence: WBPerson42
      Sequence_name: F15A2.6
      Molecular_name: F15A2.6a
        F15A2.6a.1
        CE28218
        F15A2.6b
        CE40646
        F15A2.6b.1
      Other_name: CELE_F15A2.6 Accession_evidence: NDB BX284606
      Public_name: sad-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sad
    Allele (288)
    Strain: WBStrain00002260
      WBStrain00001646
      WBStrain00005268
      WBStrain00023494
    RNASeq_FPKM (74)
    GO_annotation (35)
    Ortholog (44)
    Paralog (19)
    Structured_description: Concise_description: sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, SAD-1 functions in a complex with STRD-1, with which it physically interacts in vivo, to regulate axonal-dendritic polarity and synapse organization; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons; SAD-1 localization to synapses depends upon STRD-1; SAD-1 exhibits kinase activity in vitro, phosphorylating recombinant human Tau. Paper_evidence: WBPaper00004523
            WBPaper00035545
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Jun 2010 00:00:00
      Automated_description: Enables protein kinase activity. Involved in cellular component organization; cellular localization; and establishment or maintenance of cell polarity. Located in axon and dendrite. Expressed in nervous system. Is an ortholog of human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F15A2.6a
      F15A2.6b
    Corresponding_CDS_history: F15A2.6:wp53
    Corresponding_transcript: F15A2.6a.1
      F15A2.6b.1
    Other_sequence (26)
    Associated_feature (13)
  Experimental_info: RNAi_result (18)
    Expr_pattern: Chronogram36
      Expr812
      Expr813
      Expr814
      Expr3555
      Expr4964
      Expr4970
      Expr5763
      Expr5764
      Expr8337
      Expr11972
      Expr14693
      Expr14694
      Expr1025531
      Expr1032327
      Expr1148645
      Expr2015578
      Expr2033813
    Drives_construct: WBCnstr00000850
      WBCnstr00002485
      WBCnstr00004357
      WBCnstr00005298
      WBCnstr00013124
      WBCnstr00013265
      WBCnstr00041292
      WBCnstr00041293
    Construct_product (18)
    Antibody: WBAntibody00000343
      WBAntibody00001193
    Microarray_results (30)
    Expression_cluster: WBPaper00029359_1291
      WBPaper00032976:dosage_compensated_genes
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040285:H2S_12hr_downregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:nerve-ring_expressed
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AIB
      WBPaper00061340:AIM
      WBPaper00061340:AIN
      WBPaper00061340:AIZ
      WBPaper00061340:ALA
      WBPaper00061340:ALM_BDU
      WBPaper00061340:ALN
      WBPaper00061340:AUA
      WBPaper00061340:AVB
      WBPaper00061340:AVD
      WBPaper00061340:AVE
      WBPaper00061340:AVG
      WBPaper00061340:AVH
      WBPaper00061340:AVJ
      WBPaper00061340:CEP
      WBPaper00061340:DA_DB
      WBPaper00061340:DD
      WBPaper00061340:IL2
      WBPaper00061340:RIA
      WBPaper00061340:RIB
      WBPaper00061340:RIH
      WBPaper00061340:RIM
      WBPaper00061340:RIS
      WBPaper00061340:RMED
      WBPaper00061340:SMB
      WBPaper00061340:SMD
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00061527:syd-1_2945-unc-41_2170
      WBPaper00061651:PDB_enriched
      WBPaper00061818:ELKS-1_interacting
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:14_0
      WBPaper00065841:14_2
      WBPaper00065841:19_0
      WBPaper00065841:119_0
      WBPaper00065841:121_0
      WBPaper00065841:132_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_17
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035560:ahr-1_downregulated
      WBPaper00036286:Pattern_G
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00042548:miRISC_enriched
      WBPaper00045673:colistin_upregulated
      WBPaper00048563:L1_DD_enriched
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_A
      [cgc6390]:Cluster_B
    Interaction (33)
  Map_info: Map: X Position: 12.6561 Error: 0.012226
    Well_ordered
    Positive: Positive_clone: F15A2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4019
        4196
        4276
  Reference (54)
  Remark: [email 93 from R. Lee and cgc4523]
  Method: Gene