WBGene00001964 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | C17C3 |
| Identity | Version | 1 |
| | Name | CGC_name | hlh-25 | Person_evidence | WBPerson346 |
| | | Sequence_name | C17C3.7 |
| | | Molecular_name | C17C3.7 |
| | | | C17C3.7.1 |
| | | | CE42919 |
| | | Other_name | CELE_C17C3.7 | Accession_evidence | NDB | BX284602 |
| | | Public_name | hlh-25 |
| | DB_info | Database | AceView | gene | 2F825 |
| | | | WormQTL | gene | WBGene00001964 |
| | | | WormFlux | gene | WBGene00001964 |
| | | | NDB | locus_tag | CELE_C17C3.7 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001964|UniProtKB=Q18054 |
| | | | | family | PTHR10985 |
| | | | NCBI | gene | 182717 |
| | | | RefSeq | protein | NM_062662.3 |
| | | | SwissProt | UniProtAcc | Q18054 |
| | | | TREEFAM | TREEFAM_ID | TF322171 |
| | | | UniProt_GCRP | UniProtAcc | Q18054 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | hlh |
| | Allele (12) |
| | Strain | WBStrain00036426 |
| | RNASeq_FPKM (74) |
| | GO_annotation (14) |
| | Ortholog | WBGene00034674 | Caenorhabditis briggsae | From_analysis | OrthoMCL |
| | | WBGene00034927 | Caenorhabditis briggsae | From_analysis | OrthoMCL |
| | | WBGene00034928 | Caenorhabditis briggsae | From_analysis | OrthoMCL |
| | | | | | Inparanoid_8 |
| | | WBGene00040438 | Caenorhabditis briggsae | From_analysis | OrthoMCL |
| | | | | | Inparanoid_8 |
| | | WBGene00145392 | Caenorhabditis brenneri | From_analysis | Inparanoid_8 |
| | | WBGene00084086 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | WBGene00066683 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | WBGene00081200 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | WBGene00063416 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | WBGene00063461 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | WBGene00063415 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | WBGene00063460 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | WBGene00063413 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | WBGene00063412 | Caenorhabditis remanei | From_analysis | Inparanoid_8 |
| | | Sp34_30260200 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | Sp34_30260300 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | Sp34_30260400 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | Sp34_30260600 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | Sp34_30260700 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | Sp34_40167100 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | Sp34_40167500 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrII_pilon.g4531 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Paralog | WBGene00003008 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00001968 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00001967 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00001966 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00001965 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | hlh-25 encodes a REF-1-like protein with two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-deficient genetic backgrounds; HLH-25 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-25 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage; ectopic HLH-25 can induce body muscle development in skn-1(RNAi);pal-1(RNAi) embryos that would otherwise lack muscle; HLH-25 is required for embryonic viability in mass RNAi assays. | Paper_evidence | WBPaper00006395 |
| | | | | | WBPaper00025235 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 18 Apr 2008 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including MSpa; anal depressor muscle; body wall musculature; intestinal cell; and neurons. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C17C3.7 |
| | Corresponding_CDS_history | C17C3.7:wp193 |
| | Corresponding_transcript | C17C3.7.1 |
| | Associated_feature | WBsf978550 |
| | Transcription_factor | WBTranscriptionFactor000072 |
| Experimental_info | RNAi_result | WBRNAi00010905 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00010899 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00084010 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040773 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00024579 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040785 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027179 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr3495 |
| | | Expr8067 |
| | | Expr12501 |
| | | Expr1144824 |
| | | Expr2012500 |
| | | Expr2030739 |
| | Drives_construct | WBCnstr00005197 |
| | | WBCnstr00011427 |
| | | WBCnstr00021040 |
| | | WBCnstr00021041 |
| | | WBCnstr00036556 |
| | Construct_product | WBCnstr00005197 |
| | | WBCnstr00021041 |
| | | WBCnstr00036556 |
| | Regulate_expr_cluster | WBPaper00048624:hlh-25(ok1710)_downregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | Microarray_results (15) |
| | Expression_cluster | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00061040:eat-2(ad1116)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:ADEsh |
| | | WBPaper00061424:Diet_MYb120_downregulated |
| | | WBPaper00061527:sre-33-ZK1025.1_8337 |
| | | WBPaper00061853:osm-3(dh441)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066232:ash-2(RNAi)_upregulated_WT |
| | | cgc4489_group_21 |
| | | WBPaper00025032:cluster_134 |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00042067:Cu2+_upregulated_WT |
| | | WBPaper00045673:colistin_downregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:cluster_25 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(41_min) |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SET |
| | | [cgc5767]:expression_class_SE_pi(23_min) |
| | Interaction (59) |
| Map_info | Map | II | Position | -1.19086 | Error | 0.002255 |
| | Positive | Positive_clone | C17C3 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00025235 |
| | WBPaper00026325 |
| | WBPaper00027287 |
| | WBPaper00027309 |
| | WBPaper00029033 |
| | WBPaper00034761 |
| | WBPaper00043858 |
| | WBPaper00048624 |
| | WBPaper00061738 |
| | WBPaper00062117 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |