| WBGene00003892 | Evidence | Paper_evidence | WBPaper00019165 |
|---|
| SMap | S_parent | Sequence | Y75B8A |
| Identity | Version | 2 |
| | Name | CGC_name | osm-12 | Person_evidence | WBPerson242 |
| | | Sequence_name | Y75B8A.12 |
| | | Molecular_name | Y75B8A.12 |
| | | | Y75B8A.12.1 |
| | | | CE23024 |
| | | Other_name | bbs-7 | Paper_evidence | WBPaper00024240 |
| | | | | CGC_data_submission |
| | | | CELE_Y75B8A.12 | Accession_evidence | NDB | BX284603 |
| | | Public_name | osm-12 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 14 May 2004 16:21:16 | WBPerson1845 | Event | Acquires_merge | WBGene00000243 |
| | | Acquires_merge | WBGene00000243 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | osm |
| | Cloned_by | Person_evidence | WBPerson2136 |
| | Allele (288) |
| | Legacy_information | [C.elegansII] n1606 : defective osmotic avoidance. NA1. [MT; JT] |
| | Strain | WBStrain00001434 |
| | | WBStrain00027084 |
| | | WBStrain00031968 |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (41) |
| | Structured_description | Concise_description | osm-12 encodes a protein that is an ortholog to human BBS7; osm-12 along with bbs-8 is required for cilia biogenesis and function, accordingly, osm-12 mutant animals display odorant chemotaxis defects; oms-12 and bbs-8 are required for intraflagellar transport (IFT) and the motility and function of IFT proteins like OSM-5, CHE-11 and CHE-2; in addition to the sensory defects exhibited by bbs mutants, osm-12 and bbs-8 mutants also show reduced body size, developmental delay, and altered roaming, which are rescued by mutations in the guanylate complex GCY-35/GCY-36, suggesting that BBS proteins may regulate cGMP signaling; OSM-12 is expressed exclusively in ciliated sensory neurons, where it localizes predominantly to the base of cilia, known as the ciliary transition zone; DNA sequences upstream of osm-12 contain X box DNA binding sites, suggesting that osm-12 expression may be regulated by the DAF-19 RFX-type transcription factor. | Paper_evidence | WBPaper00024240 |
| | | | | | WBPaper00040341 |
| | | | | | WBPaper00028530 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 01 Feb 2012 00:00:00 |
| | | Automated_description | Involved in chemotaxis; cilium organization; and protein localization to microvillus membrane. Located in ciliary basal body; neuron projection; and non-motile cilium. Expressed in ciliated neurons and sensory neurons. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 7. Is an ortholog of human BBS7 (Bardet-Biedl syndrome 7). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1935 | Homo sapiens | Paper_evidence | WBPaper00040341 |
| | | | | | WBPaper00024240 |
| | | | | | WBPaper00046099 |
| | | | | Accession_evidence | OMIM | 209900 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 08 May 2017 00:00:00 |
| | Potential_model | DOID:0110129 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18758) |
| | | DOID:1935 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18758) |
| | Disease_relevance | The human ortholog BBS7 is mutated in Bardet-Biedl syndrome 7; Bardet-Biedl syndrome phenotypes include retinal degeneration, obesity, renal malformations, polydactyly and learning disabilities; studies in the worm have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; most of the known BBS proteins in human and elegans encode basal body or cilia proteins involved in ciliary structure and function including intraflagellar transport (IFT); studies in C. elegans indicate that transcription of BBS proteins is regulated by a RFX-transcription factor and that some BBS proteins may also regulate GCY-35/GCY-36 cGMP signaling which can affect BBS mutant gene phenotypes. | Homo sapiens | Paper_evidence | WBPaper00040341 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 08 May 2017 00:00:00 |
| Models_disease_asserted | WBDOannot00000040 |
| | WBDOannot00000413 |
| | WBDOannot00000415 |
| | WBDOannot00000416 |
| Molecular_info | Corresponding_CDS | Y75B8A.12 |
| | Corresponding_transcript | Y75B8A.12.1 |
| | Other_sequence | Tcir_isotig07366 |
| | | FC544675.1 |
| | | Oden_isotig22323 |
| | | ACC12170_1 |
| | | Acan_isotig10177 |
| | Associated_feature | WBsf047490 |
| | | WBsf651528 |
| | | WBsf667505 |
| | | WBsf667506 |
| | | WBsf994597 |
| | | WBsf994598 |
| | | WBsf1016160 |
| Experimental_info | RNAi_result | WBRNAi00058439 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00037840 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00095207 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00006795 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr3405 |
| | | Expr3698 |
| | | Expr3723 |
| | | Expr7125 |
| | | Expr10119 |
| | | Expr1029180 |
| | | Expr1031835 |
| | | Expr1161858 |
| | | Expr2014641 |
| | | Expr2032874 |
| | Drives_construct (13) |
| | Construct_product | WBCnstr00008464 |
| | | WBCnstr00011383 |
| | | WBCnstr00011609 |
| | | WBCnstr00015627 |
| | | WBCnstr00015644 |
| | | WBCnstr00015645 |
| | | WBCnstr00015653 |
| | | WBCnstr00035808 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:all-neurons_CoreEnriched |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049001:EVN_enriched |
| | | WBPaper00049334:CE_intestine_enriched |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055226:ADR-2_target_adr-1(tm668) |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADE |
| | | WBPaper00061340:ADF |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:ADL |
| | | WBPaper00061340:AFD |
| | | WBPaper00061340:ASE |
| | | WBPaper00061340:ASE_parent |
| | | WBPaper00061340:ASG |
| | | WBPaper00061340:ASG_AWA |
| | | WBPaper00061340:ASH |
| | | WBPaper00061340:ASI |
| | | WBPaper00061340:ASI_parent |
| | | WBPaper00061340:ASJ |
| | | WBPaper00061340:ASK |
| | | WBPaper00061340:ASK_parent |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:AWA |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:AWC |
| | | WBPaper00061340:BAG |
| | | WBPaper00061340:CEP |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061340:Neuroblast_ADE_ADA |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:OLL_parent |
| | | WBPaper00061340:OLQ |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:URX |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:rab-28-jbts-14_9542 |
| | | WBPaper00061651:PHB_enriched |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:25_0 |
| | | WBPaper00065841:25_1 |
| | | WBPaper00065841:36_0 |
| | | WBPaper00065841:36_2 |
| | | WBPaper00065841:36_3 |
| | | WBPaper00065841:39_0 |
| | | WBPaper00065841:39_1 |
| | | WBPaper00065841:39_2 |
| | | WBPaper00065841:44_0 |
| | | WBPaper00065841:44_1 |
| | | WBPaper00065841:47_0 |
| | | WBPaper00065841:71_0 |
| | | WBPaper00065841:84_0 |
| | | WBPaper00065841:100_0 |
| | | WBPaper00065841:124_0 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00039866:ClassComp_daf-19_downregulated |
| | | WBPaper00039866:SAM_daf-19_downregulated |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041609:hpl-1_hpl-2_upregulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (28) |
| | Anatomy_function | WBbtf0480 |
| Map_info | Map | III | Position | 16.0844 | Error | 0.181973 |
| | Positive | Positive_clone | Y75B8A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 3725 |
| | | Multi_point | 1364 |
| | | | 5667 |
| Reference (42) |
| Method | Gene |
