WormBase Tree Display for Gene: WBGene00009368

WBGene00009368 SMap: S_parent: Sequence: F33H2
  Identity: Version: 2
    Name: CGC_name: pole-1 Person_evidence: WBPerson320
            WBPerson30839
      Sequence_name: F33H2.5
      Molecular_name: F33H2.5
        F33H2.5.1
        CE17767
      Other_name: CELE_F33H2.5 Accession_evidence: NDB BX284601
      Public_name: pole-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 14 Apr 2015 09:52:28 WBPerson2970 Name_change: CGC_name: pole-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pole
    Allele (109)
    Possibly_affected_by: WBVar02152931
    Strain: WBStrain00001140
      WBStrain00035526
      WBStrain00054796
    RNASeq_FPKM (74)
    GO_annotation (33)
    Ortholog (52)
    Structured_description: Automated_description: Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and single-stranded DNA 3'-5' DNA exonuclease activity. Predicted to be involved in DNA metabolic process and mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of epsilon DNA polymerase complex. Human ortholog(s) of this gene implicated in ascending colon cancer; carcinoma (multiple); and mismatch repair cancer syndrome. Is an ortholog of human POLE (DNA polymerase epsilon, catalytic subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9177)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9177)
      DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9177)
      DOID:218 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9177)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9177)
      DOID:3907 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9177)
      DOID:1380 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9177)
      DOID:0112182 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9177)
  Molecular_info: Corresponding_CDS: F33H2.5
    Corresponding_transcript: F33H2.5.1
    Other_sequence (12)
    Associated_feature: WBsf976630
      WBsf986297
      WBsf986298
      WBsf1011328
      WBsf220675
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr5945
      Expr1013626
      Expr1034102
      Expr1150129
      Expr2014990
      Expr2033225
    Drives_construct: WBCnstr00002036
      WBCnstr00032247
    Construct_product: WBCnstr00032247
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_lin-35
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00038168:lin-35_upregulated
      WBPaper00044037:eat-2_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00051039:germline_enriched
      WBPaper00051265:F1_morc-1(tm6048)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061106:endu-2(tm4977)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:Excretory_cell_parent
      WBPaper00061340:Neuroblast_AIZ_FLP_RMG
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061527:F54E7.8-orc-5_6376
      WBPaper00061699:daf-18(ok480)_upregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062056:efl-1(se1)_upregulated
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-36(we31)_upregulated
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_5_3
      cgc4489_group_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_B
      WBPaper00040821:Au-NP_regulated
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042274:tbx-2(bx59)_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055435:AuNPs_downregulated
      [cgc5767]:cluster_74
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(143_min)
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_F
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (164)
  Map_info: Map: I Position: 29.2714
    Positive: Positive_clone: F33H2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00023755
    WBPaper00026064
    WBPaper00029334
    WBPaper00038491
    WBPaper00055090
    WBPaper00062439
    WBPaper00064339
    WBPaper00066002
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene