| WBGene00010251 | SMap | S_parent | Sequence | F58E6 |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | sta-2 | Person_evidence | WBPerson168 |
| | | Sequence_name | F58E6.1 |
| | | Molecular_name | F58E6.1 |
| | | | F58E6.1.1 |
| | | | CE42515 |
| | | Other_name | CELE_F58E6.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | sta-2 |
| | DB_info | Database | AceView | gene | 5K227 |
| | | | | | 5K225 |
| | | | WormQTL | gene | WBGene00010251 |
| | | | WormFlux | gene | WBGene00010251 |
| | | | NDB | locus_tag | CELE_F58E6.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00010251|UniProtKB=Q20977 |
| | | | | family | PTHR11801 |
| | | | NCBI | gene | 3565291 |
| | | | RefSeq | protein | NM_001129491.3 |
| | | | SwissProt | UniProtAcc | Q20977 |
| | | | UniProt_GCRP | UniProtAcc | Q20977 |
| | | | OMIM | gene | 102582 |
| | | | | | 600555 |
| | | | | | 600558 |
| | | | | | 604260 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 27 Mar 2008 16:32:26 | WBPerson4025 | Event | Split_into | WBGene00077697 |
| | | | 3 | 26 Nov 2009 11:16:28 | WBPerson9133 | Name_change | CGC_name | sta-2 |
| | | Split_into | WBGene00077696 |
| | | | WBGene00077697 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sta |
| | Allele (32) |
| | Strain | WBStrain00032243 |
| | | WBStrain00021985 |
| | | WBStrain00021988 |
| | | WBStrain00047518 |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (51) |
| | Paralog | WBGene00013111 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | sta-2 encodes a member of the STAT family of transcription factors; STA-2 functions cell autonomously together with the SNF-12 sodium-dependent neurotransmitter symporter to regulate expression of antimicrobial peptides in the epidermis following fungal infection and physical wounding; STA-2 physically interacts with SNF-12; a sta-2 reporter gene is expressed in the epidermis throughout development and in the seam cells, intestine, phasmid socket cells, excretory duct cell, vulval cells and the dorsal rectal cells; STA-2 localizes to both the nucleus and the cytoplasm; in the epidermal cytoplasm, STA-2 colocalizes with SNF-12 in endocytic-like vesicles near the apical cell surface. | Paper_evidence | WBPaper00038424 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 12 May 2014 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to fungus; positive regulation of antifungal peptide production; and response to wounding. Located in several cellular components, including apical part of cell; endocytic vesicle; and hemidesmosome. Part of hemidesmosome associated protein complex. Expressed in hypodermis; interfacial epithelial cell; intestine; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including STAT1 (signal transducer and activator of transcription 1); STAT3 (signal transducer and activator of transcription 3); and STAT4 (signal transducer and activator of transcription 4). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (70) |
| Molecular_info | Corresponding_CDS | F58E6.1 |
| | Corresponding_CDS_history | F58E6.1:wp20 |
| | | F58E6.1a:wp189 |
| | | F58E6.1b:wp189 |
| | Corresponding_transcript | F58E6.1.1 |
| | Other_sequence (45) |
| | Associated_feature | WBsf647106 |
| | | WBsf647107 |
| | | WBsf661585 |
| | | WBsf661586 |
| | Transcription_factor | WBTranscriptionFactor000235 |
| Experimental_info | RNAi_result | WBRNAi00095190 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00095188 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001833 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00093457 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00110863 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00093455 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00095189 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00015982 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049009 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00115101 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr9295 |
| | | Expr9296 |
| | | Expr1023653 |
| | | Expr1034471 |
| | | Expr1152745 |
| | | Expr2016952 |
| | | Expr2035100 |
| | Drives_construct | WBCnstr00008724 |
| | | WBCnstr00008725 |
| | | WBCnstr00008726 |
| | Construct_product | WBCnstr00008727 |
| | | WBCnstr00008728 |
| | | WBCnstr00008729 |
| | | WBCnstr00008730 |
| | | WBCnstr00013880 |
| | Antibody | WBAntibody00002618 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032031:DConiospora_upregulated_OligoArray_24h |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00038237:age-1_upregulated_intestine_rescue |
| | | WBPaper00038237:age-1_upregulated_neuron_rescue |
| | | WBPaper00038237:age-1_upregulated_nontransgenic |
| | | WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00040560:hpl-2_embryo_upregulated |
| | | WBPaper00042165:let-7_downregulated |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00045017:blmp-1(tm548)_upregulated |
| | | WBPaper00045257:bar-1(ga80)_downregulated |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00050121:mir-60(n4947)_upregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050801:DAF-12_dauer_regulome |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:epidermis_specific |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053664:ins-11(tm1053)_downregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00054872:egl-9(sa307)_downregulated |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055648:sperm_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055941:nuo-6(qm200)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057143:ztf-11(RNAi)_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059537:ngn-1(ok2200)_upregulated |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_L1 |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060703:nas-38(ok3407)_upregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:nhr-18-C34D1.4_6256 |
| | | WBPaper00061651:PHso_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_AFD |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062590:Aging_downregulated_hypodermis |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064762:freezing-thaw_regulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:0_0 |
| | | WBPaper00065841:21_0 |
| | | WBPaper00065841:21_1 |
| | | WBPaper00065841:30_1 |
| | | WBPaper00065841:30_2 |
| | | WBPaper00065841:33_0 |
| | | WBPaper00065841:33_1 |
| | | WBPaper00065841:34_0 |
| | | WBPaper00065841:34_1 |
| | | WBPaper00065841:64_0 |
| | | WBPaper00065841:79_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | cgc4386_cluster_5_4 |
| | | cgc4489_group_17 |
| | | cgc4489_male_enriched_transcription_factors |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00037113:CPF_16C_up-regulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:DAF-16-dependent_UV_response |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_B |
| | Interaction (18) |
| | WBProcess | WBbiopr:00000039 |
| Map_info | Map | V | Position | 2.14428 | Error | 0.003978 |
| | Positive | Positive_clone | F58E6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (20) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
