e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1.
[C.elegansII] e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. [Brenner 1974]
unc-77 encodes, along with nca-2, one of two C. elegans alpha-1-like subunits of a voltage-insensitive cation leak channel related to Drosophila narrow abdomen and the vertebrate Vgcnl1/NALCN proteins; unc-77 functions redundantly with nca-2 to transmit depolarization signals from neuronal cell bodies to axons, thus regulating presynaptic activation; unc-77 and nca-2 are also required for normal locomotion and the response to specific volatile anesthetics; in regulating synaptic activity, unc-77 appears to function in the same pathway as unc-79 and unc-80, which encode novel conserved proteins that reciprocally regulate UNC-77 expression; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-77::gfp reporter fusion is expressed in many sensory and all motoneurons; in the dorsal and ventral nerve cords, UNC-77 localizes to specific axonal regions, but not to synapses.
Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Expressed in cholinergic neurons; nerve ring; pharyngeal neurons; and tail ganglion. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective).