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WormBase Tree Display for Gene: WBGene00006809

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Name Class

WBGene00006809SMapS_parentSequenceC11D2
IdentityVersion2
NameCGC_nameunc-77Person_evidenceWBPerson261
Sequence_nameC11D2.6
Molecular_name (48)
Other_namenca-1Paper_evidenceWBPaper00031592
Person_evidenceWBPerson604
CELE_C11D2.6Accession_evidenceNDBBX284604
Public_nameunc-77
DB_infoDatabase (10)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
203 Dec 2009 11:55:50WBPerson2970EventAcquires_mergeWBGene00003557
Acquires_mergeWBGene00003557
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143348
Allele (298)
Legacy_informatione625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1.
[C.elegansII] e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. [Brenner 1974]
StrainWBStrain00035028
WBStrain00035029
WBStrain00035482
WBStrain00040855
WBStrain00040862
WBStrain00040863
WBStrain00040864
WBStrain00040865
WBStrain00006352
Component_of_genotypeWBGenotype00000089
WBGenotype00000090
WBGenotype00000091
RNASeq_FPKM (74)
GO_annotation (18)
OrthologWBGene00066082Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00027947Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00037668Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00122833Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00140494Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00154155Caenorhabditis brenneriFrom_analysisTreeFam
WormBase-Compara
WBGene00135142Caenorhabditis japonicaFrom_analysisTreeFam
WormBase-Compara
WBGene00107390Pristionchus pacificusFrom_analysisInparanoid_8
WBGene00153171Caenorhabditis brenneriFrom_analysisWormBase-Compara
WBGene00222695Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g8570Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g184Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g185Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g14560Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP26.g16683Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g21109Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g10428Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g7911Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP31.g7912Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g10214Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g2263Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g15963Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g17987Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g25086Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g5565Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g10670Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_06589.g20353Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-unc-77Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g17351Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00045.g2385Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_18713Caenorhabditis latensFrom_analysisWormBase-Compara
FL83_18714Caenorhabditis latensFrom_analysisWormBase-Compara
FL83_20372Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_013653Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g12811Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g14329Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_40161400Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIV_pilon.g10560Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00073165Caenorhabditis remaneiFrom_analysisWormBase-Compara
WBGene00074869Caenorhabditis remaneiFrom_analysisWormBase-Compara
WBGene00080174Caenorhabditis remaneiFrom_analysisWormBase-Compara
WBGene00084742Caenorhabditis remaneiFrom_analysisWormBase-Compara
WBGene00245319Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00092845Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00266153Strongyloides rattiFrom_analysisWormBase-Compara
SGD:S000003449Saccharomyces cerevisiaeFrom_analysisOMA
OrthoInspector
PhylomeDB
FB:FBgn0002917Drosophila melanogasterFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-050410-12Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:19082Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2444306Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:628710Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ParalogWBGene00003558Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00000367Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001187Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00006742Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00008911Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionunc-77 encodes, along with nca-2, one of two C. elegans alpha-1-like subunits of a voltage-insensitive cation leak channel related to Drosophila narrow abdomen and the vertebrate Vgcnl1/NALCN proteins; unc-77 functions redundantly with nca-2 to transmit depolarization signals from neuronal cell bodies to axons, thus regulating presynaptic activation; unc-77 and nca-2 are also required for normal locomotion and the response to specific volatile anesthetics; in regulating synaptic activity, unc-77 appears to function in the same pathway as unc-79 and unc-80, which encode novel conserved proteins that reciprocally regulate UNC-77 expression; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-77::gfp reporter fusion is expressed in many sensory and all motoneurons; in the dorsal and ventral nerve cords, UNC-77 localizes to specific axonal regions, but not to synapses.Paper_evidenceWBPaper00030757
WBPaper00031000
WBPaper00031592
Curator_confirmedWBPerson1843
Date_last_updated22 Jun 2010 00:00:00
Automated_descriptionEnables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Expressed in cholinergic neurons; nerve ring; pharyngeal neurons; and tail ganglion. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:0081048Homo sapiensPaper_evidenceWBPaper00046648
Curator_confirmedWBPerson324
Date_last_updated09 Feb 2022 00:00:00
Potential_modelEFO:MONDO:0014176Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:19082)
DOID:0081048Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:19082)
Models_disease_assertedWBDOannot00001101
WBDOannot00001105
Molecular_infoCorresponding_CDS (16)
Corresponding_CDS_historyC11D2.6a:wp239
C11D2.6b:wp239
C11D2.6c:wp239
Corresponding_transcript (16)
Other_sequence (15)
Associated_featureWBsf651837
WBsf996705
WBsf996706
WBsf996707
WBsf996708
WBsf996709
WBsf1017492
WBsf1017493
WBsf230141
WBsf230142
Experimental_infoRNAi_result (15)
Expr_patternChronogram197
Expr4860
Expr5240
Expr8058
Expr8060
Expr8194
Expr8324
Expr1144413
Expr2017906
Expr2036042
Drives_construct (12)
Construct_productWBCnstr00017151
WBCnstr00021676
WBCnstr00021677
WBCnstr00021678
WBCnstr00021679
WBCnstr00021680
WBCnstr00021681
WBCnstr00037886
AntibodyWBAntibody00001260
WBAntibody00001384
Microarray_results (48)
Expression_cluster (190)
Interaction (21)
Map_infoMapIVPosition3.08555
PositivePositive_cloneC11D2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point323
Multi_point1422
4509
Reference (42)
MethodGene