WormBase Tree Display for Gene: WBGene00001172
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| WBGene00001172 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C51E3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | egl-3 | Person_evidence | WBPerson268 | |||||
| Sequence_name | C51E3.7 | ||||||||
| Molecular_name | C51E3.7a | ||||||||
| C51E3.7a.1 | |||||||||
| CE08940 | |||||||||
| C51E3.7c | |||||||||
| CE45708 | |||||||||
| C51E3.7c.1 | |||||||||
| Other_name (3) | |||||||||
| Public_name | egl-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | egl | ||||||||
| Reference_allele | WBVar00089286 | ||||||||
| Allele (73) | |||||||||
| Legacy_information | n150ts : Type C Egl moderate bloating coiler phenotype. ES3 (adult 25x) ES2 (larvae males). NA4 (n588 : weakly semidominant n729 etc.). | ||||||||
| See also n729 | |||||||||
| [C.elegansII] n150ts : moderate bloating Egl, stimulated by serotonin and by imipramine; coiler phenotype. ES3 (adult 25C) ES2 (larvae, males) ME2. OA3: n588 (weakly semidominant), n729. [Trent et al. 1983; MT] | |||||||||
| Strain | WBStrain00001494 | ||||||||
| WBStrain00026704 | |||||||||
| WBStrain00026820 | |||||||||
| WBStrain00026821 | |||||||||
| WBStrain00026865 | |||||||||
| WBStrain00035788 | |||||||||
| WBStrain00035966 | |||||||||
| WBStrain00051862 | |||||||||
| WBStrain00055163 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (78) | |||||||||
| Contained_in_operon | CEOP5505 | ||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000088 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000254 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002232 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00017686 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | The egl-3 gene encodes a homolog of a mammalian proprotein convertase that participates in peptide secretion. | Paper_evidence | WBPaper00004518 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables FBXO family protein binding activity and serine-type endopeptidase activity. Involved in several processes, including modulation of chemical synaptic transmission; protein processing; and regulation of multicellular organismal process. Located in axon. Expressed in several structures, including mechanosensory neurons; nerve ring; pharynx; tail; and uv1. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Is an ortholog of human PCSK2 (proprotein convertase subtilisin/kexin type 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00036327 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jun 2019 00:00:00 | ||||||||
| Potential_model | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8744) | |||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8744) | ||||||
| Models_disease_asserted | WBDOannot00000710 | ||||||||
| Molecular_info | Corresponding_CDS | C51E3.7a | |||||||
| C51E3.7c | |||||||||
| Corresponding_CDS_history | C51E3.7b:wp261 | ||||||||
| Corresponding_transcript | C51E3.7a.1 | ||||||||
| C51E3.7c.1 | |||||||||
| Other_sequence (127) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00002351 | ||||||||
| WBCnstr00004319 | |||||||||
| WBCnstr00008114 | |||||||||
| WBCnstr00018293 | |||||||||
| WBCnstr00020688 | |||||||||
| WBCnstr00037050 | |||||||||
| Construct_product | WBCnstr00011520 | ||||||||
| WBCnstr00017600 | |||||||||
| WBCnstr00017601 | |||||||||
| WBCnstr00021861 | |||||||||
| WBCnstr00037050 | |||||||||
| Antibody | WBAntibody00000429 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (306) | |||||||||
| Interaction (98) | |||||||||
| Anatomy_function | WBbtf0062 | ||||||||
| WBbtf0209 | |||||||||
| WBbtf0210 | |||||||||
| WBbtf1042 | |||||||||
| Map_info | Map | V | Position | 2.28568 | Error | 0.005714 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mDf1 | |||||||
| Positive_clone | C51E3 | Person_evidence | WBPerson1139 | ||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 715 | |||||||
| Multi_point | 329 | ||||||||
| 608 | |||||||||
| 609 | |||||||||
| 797 | |||||||||
| 953 | |||||||||
| 5581 | |||||||||
| Pos_neg_data | 1732 | ||||||||
| 1733 | |||||||||
| 1734 | |||||||||
| 1741 | |||||||||
| Reference (102) | |||||||||
| Remark | sequence connection from [Kass J, Kaplan JM] | ||||||||
| Sequence connection from [Thacker C] | |||||||||
| old_name kpc-2 becomes new_name egl-3 from [Thacker C]. | |||||||||
| Method | Gene |
