WormBase Tree Display for Gene: WBGene00001204
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| WBGene00001204 | SMap | S_parent | Sequence | C04G2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | egl-38 | Person_evidence | WBPerson268 | |||||
| Sequence_name | C04G2.7 | ||||||||
| Molecular_name | C04G2.7 | ||||||||
| C04G2.7.1 | |||||||||
| CE05215 | |||||||||
| Other_name | lin-50 | ||||||||
| CELE_C04G2.7 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | egl-38 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | egl | ||||||||
| Allele (61) | |||||||||
| Legacy_information | n578 : severe bloating Type A almost no egg-laying almost all animals form bag-of-worms ( > 90%); uncoordinated very sluggish phenotype; abnormal vulva. ES3 (all stages). NA1. | ||||||||
| See also n578 | |||||||||
| [Chamberlin HM] Homozygous sy294 males have abnormal tails with U and B lineage defects. Hermaphrodites also have abnormal tails, and are frequently sterile. | |||||||||
| [C.elegansII] n578 : severe bloating; insensitive to serotonin and imipramine; almost no egg-laying, >90% adults form bag-of-worms (>90%); defect in vulval-uterine attachment, persistent survival of AC; uncoordinated very sluggish phenotype; abnormal vulva. ES3 (all stages). OA2: sy294 (pka lin-50, males have abnormal tails with U and B lineage defects; hermaphrodites also have abnormal tails, frequently sterile), s1775. [Trent et al. 1983; MT; PS] | |||||||||
| Complementation_data | [Chamberlin HM] complements let-53(s43), let-658(s1107), let-659(s1152), elt-1(zu180) | ||||||||
| [Chamberlin HM ] fails to complement egl-38(n578) | |||||||||
| Strain | WBStrain00035271 | ||||||||
| WBStrain00026815 | |||||||||
| WBStrain00037544 | |||||||||
| WBStrain00000669 | |||||||||
| WBStrain00000924 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (43) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | egl-38 encodes a paired domain-containing protein that is a member of the PAX2/5/8 family of transcription factors; egl-38 is an essential gene, required for embryonic and larval development; in addition, EGL-38 activity is also required for fate specification of four uterine cells and rectal epithelial cells in the hermaphrodite and male tail; in regulating hindgut development EGL-38 acts in a pathway with LIN-48, a zinc-finger transcription factor; EGL-38 regulates lin-48 expression in vivo and binds to the lin-48 promoter region in vitro. | Paper_evidence | WBPaper00002924 | |||||
| WBPaper00004826 | |||||||||
| WBPaper00004954 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 30 Jun 2011 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including developmental process involved in reproduction; positive regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of chromatin. Expressed in body wall musculature; egg-laying apparatus; head neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital nongoitrous hypothyroidism 2; focal segmental glomerulosclerosis 7; and renal Wilms' tumor. Is an ortholog of human PAX2 (paired box 2); PAX5 (paired box 5); and PAX8 (paired box 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:5176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8616) | ||||
| DOID:2154 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8616) | ||||||
| DOID:0111132 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8616) | ||||||
| DOID:0090006 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8616) | ||||||
| DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8619) | ||||||
| DOID:0050328 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8622) | ||||||
| DOID:0070124 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8622) | ||||||
| DOID:784 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8616) | ||||||
| Molecular_info | Corresponding_CDS | C04G2.7 | |||||||
| Corresponding_transcript | C04G2.7.1 | ||||||||
| Other_sequence | AF002702 | ||||||||
| Dviv_isotig17261 | |||||||||
| Oden_isotig19878 | |||||||||
| JI173248.1 | |||||||||
| MI02123 | |||||||||
| Dviv_isotig17260 | |||||||||
| TX00931 | |||||||||
| JI212121.1 | |||||||||
| Associated_feature | WBsf047561 | ||||||||
| WBsf652106 | |||||||||
| WBsf668205 | |||||||||
| WBsf978357 | |||||||||
| WBsf230668 | |||||||||
| Gene_product_binds | WBsf027925 | ||||||||
| WBsf047568 | |||||||||
| WBsf047569 | |||||||||
| WBsf919599 | |||||||||
| Transcription_factor | WBTranscriptionFactor000031 | ||||||||
| Experimental_info | RNAi_result (9) | ||||||||
| Expr_pattern | Chronogram1920 | ||||||||
| Expr4259 | |||||||||
| Expr7411 | |||||||||
| Expr12305 | |||||||||
| Expr1015642 | |||||||||
| Expr1030765 | |||||||||
| Expr1143756 | |||||||||
| Expr1200032 | |||||||||
| Expr2011220 | |||||||||
| Expr2029456 | |||||||||
| Drives_construct | WBCnstr00001057 | ||||||||
| WBCnstr00011865 | |||||||||
| WBCnstr00012554 | |||||||||
| WBCnstr00037035 | |||||||||
| Construct_product | WBCnstr00001998 | ||||||||
| WBCnstr00005635 | |||||||||
| WBCnstr00005636 | |||||||||
| WBCnstr00005637 | |||||||||
| WBCnstr00005638 | |||||||||
| WBCnstr00005639 | |||||||||
| WBCnstr00016697 | |||||||||
| WBCnstr00037035 | |||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (98) | |||||||||
| Interaction (107) | |||||||||
| Map_info | Map | IV | Position | 4.52953 | Error | 0.005038 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C04G2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| C35E5 | |||||||||
| ZK1258 | |||||||||
| Mapping_data | 2_point | 7017 | |||||||
| Multi_point | 737 | ||||||||
| 3430 | |||||||||
| 3130 | |||||||||
| 3131 | |||||||||
| 3724 | |||||||||
| 4260 | |||||||||
| 4498 | |||||||||
| Pos_neg_data | 8489 | ||||||||
| 8490 | |||||||||
| 8491 | |||||||||
| 8606 | |||||||||
| 8607 | |||||||||
| Reference (74) | |||||||||
| Picture | WBPicture0000013091 | ||||||||
| Method | Gene |
