WormBase Tree Display for Gene: WBGene00006810
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WBGene00006810 | SMap | S_parent | Sequence | C04F6 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | unc-78 | Person_evidence | WBPerson261 | |||||
Sequence_name | C04F6.4 | ||||||||
Molecular_name | C04F6.4a | ||||||||
C04F6.4a.1 | |||||||||
CE03924 | |||||||||
C04F6.4b | |||||||||
Other_name | CELE_C04F6.4 | Accession_evidence | NDB | BX284606 | |||||
Public_name | unc-78 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143840 | ||||||||
Allele (45) | |||||||||
Legacy_information | e1217 : slow abnormal body muscle birefringence abnormal muscle ultrastructure with large aggregates of thin filaments; suppressed to wildtype by sup-13. ES2 ME0. NA > 5 (e1221 st43 etc.). | ||||||||
See also e1217, e1221 | |||||||||
[C.elegansII] e1217 : slow, abnormal body muscle birefringence, abnormal muscle ultrastructure with large aggregates of thin filaments; suppressed to wildtype by sup-13. ES2 ME0. OA>5: e1221, st43 etc. [Waterston et al. 1980] | |||||||||
[S Ono] slow moving, actin filaments become aggregated in body wall muscle. | |||||||||
[Ono S] unc-78 cloned, is C04F6.4 encoding homolog of actin-interacting protein 1, required for organized assembly of muscle actin filaments | |||||||||
Strain | WBStrain00001852 | ||||||||
WBStrain00026896 | |||||||||
WBStrain00033511 | |||||||||
WBStrain00035493 | |||||||||
WBStrain00004274 | |||||||||
WBStrain00006316 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (23) | |||||||||
Ortholog (45) | |||||||||
Paralog | WBGene00010685 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | unc-78 encodes a WD40 repeat-containing protein homologous to actin-interacting protein (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils; homozygous unc-78 mutant animals are viable but exhibit disorganization of actin filaments in the body wall muscle; unc-78 and aipl-1 have redundant and overlapping functions in organized assembly of actin filaments in embryonic muscle and that unc-78 and aipl-1 double mutant is embryonic lethal; both isoforms preferentially cooperate with UNC-60B, a muscle-specific ADF/cofilin for actin filament disassembly in embryonic muscle; UNC-78 is expressed in embryonic pharynx and body wall muscles; in adults it is expressed in spermatheca, the myoepithelial sheath, the uterus, adult vulva; UNC-78 isoform majorly functions in post-embryonic muscle most likely due to its expression in larval and adult muscles and that AIPL-1 can compensate for the function of UNC-78 in the body wall muscle. | Paper_evidence | WBPaper00038403 | |||||
Curator_confirmed | WBPerson12884 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 12 May 2011 00:00:00 | ||||||||
Automated_description | Enables actin filament binding activity. Involved in several processes, including myofibril assembly; regulation of actin polymerization or depolymerization; and regulation of locomotion. Located in myofibril and sarcoplasm. Expressed in body wall musculature; pharynx; spermatheca; uterus; and vulva. Is an ortholog of human WDR1 (WD repeat domain 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C04F6.4a | |||||||
Corresponding_CDS_history | C04F6.4b:wp252 | ||||||||
Corresponding_transcript | C04F6.4b | ||||||||
C04F6.4a.1 | |||||||||
Other_sequence (75) | |||||||||
Associated_feature | WBsf653840 | ||||||||
WBsf653841 | |||||||||
WBsf1004608 | |||||||||
WBsf237177 | |||||||||
WBsf237178 | |||||||||
Experimental_info | RNAi_result (20) | ||||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00002644 | ||||||||
WBCnstr00011892 | |||||||||
Construct_product | WBCnstr00011504 | ||||||||
WBCnstr00011892 | |||||||||
Antibody | WBAntibody00000674 | ||||||||
Microarray_results (29) | |||||||||
Expression_cluster (136) | |||||||||
Interaction (63) | |||||||||
Map_info | Map | X | Position | -10.3431 | Error | 0.00338 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | yDp13 | |||||||
yDp14 | |||||||||
yDp15 | |||||||||
Positive_clone | C04F6 | Person_evidence | WBPerson463 | ||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | 2_point | 161 | |||||||
Multi_point (15) | |||||||||
Pos_neg_data (18) | |||||||||
Reference (43) | |||||||||
Remark | Data extracted from Ono (2001) | ||||||||
Method | Gene |