Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00001487

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00001487SMapS_parentSequenceT04B2
IdentityVersion1
NameCGC_namefrk-1Person_evidenceWBPerson575
Sequence_nameT04B2.2
Molecular_nameT04B2.2a
T04B2.2a.1
CE03609
T04B2.2a.2
T04B2.2b
T04B2.2c
Other_nameCELE_T04B2.2Accession_evidenceNDBBX284604
Public_namefrk-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfrk
Allele (33)
Legacy_informationfrk-1 stands for fer-related kinase (this gene is a member of the fes/fps family of non-receptor tyrosine kinases of which the human homolog, fer, is a member as well)
StrainWBStrain00035871
RNASeq_FPKM (74)
GO_annotation (42)
Ortholog (42)
ParalogWBGene00000018Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000186Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000812Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004395Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006868Caenorhabditis elegansFrom_analysisTreeFam
WBGene00004962Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003374Caenorhabditis elegansFrom_analysisTreeFam
WBGene00006941Caenorhabditis elegansFrom_analysisTreeFam
WBGene00020289Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00012010Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00005078Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002213Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00012172Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00021151Caenorhabditis elegansFrom_analysisTreeFam
WBGene00020003Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00005077Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00017039Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00022780Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00012632Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00021635Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00013475Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00010712Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00012011Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00021793Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00009160Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00011039Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00022634Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002212Caenorhabditis elegansFrom_analysisTreeFam
WBGene00002208Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00018999Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00016954Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00016085Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00014005Caenorhabditis elegansFrom_analysisTreeFam
WBGene00002194Caenorhabditis elegansFrom_analysisTreeFam
Panther
WBGene00017736Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00013801Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002206Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00020659Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002198Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00012270Caenorhabditis elegansFrom_analysisTreeFam
WBGene00002205Caenorhabditis elegansFrom_analysisTreeFam
WBGene00016416Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00015087Caenorhabditis elegansFrom_analysisTreeFam
WBGene00006895Caenorhabditis elegansFrom_analysisTreeFam
WBGene00020966Caenorhabditis elegansFrom_analysisTreeFam
WBGene00002193Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00002204Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00021745Caenorhabditis elegansFrom_analysisTreeFam
WBGene00002211Caenorhabditis elegansFrom_analysisTreeFam
WBGene00016462Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00008711Caenorhabditis elegansFrom_analysisTreeFam
WBGene00013811Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00009039Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00012785Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00019081Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00015994Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00077712Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002207Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00014813Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionfrk-1 encodes a non-receptor tyrosine kinase orthologous to the human proto-oncogene Fer; frk-1 is an essential gene required early for embryonic cell proliferation and later in embryonic epidermal cells for enclosure, morphogenesis and late stages of differentiation; FRK-1's role in embryonic development is independent of its kinase domain, and when expressed in cultured mammalian cells, FRK-1 disrupts cell adhesion; FRK-1 is initially expressed in all cells of the early embryo where it localizes to nuclei and points of cell-cell contact; later expression is seen in epithelial cells, body wall muscle, and the adult germline, including mature sperm; FRK-1 expression in epidermal cells requires activity of the ELT-1 GATA transcription factor, and FRK-1 localization to the plasma membrane requires PAT-3/Beta-integrin, JAC-1/p120 catenin, and HMP-2/Beta-catenin with which FRK-1 interacts in vitro.Paper_evidenceWBPaper00026609
Curator_confirmedWBPerson48
WBPerson1843
Date_last_updated04 May 2007 00:00:00
Automated_descriptionEnables beta-catenin binding activity and protein kinase activity. Involved in several processes, including embryonic body morphogenesis; negative regulation of canonical Wnt signaling pathway; and regulation of epidermal cell differentiation. Located in several cellular components, including cell-cell junction; nucleus; and plasma membrane. Expressed in several structures, including germ line; hermaphrodite gonad; hypodermis; intestine; and sperm. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Is an ortholog of human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3748Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3657)
DOID:3910Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3657)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3657)
Molecular_infoCorresponding_CDST04B2.2a
Corresponding_CDS_historyT04B2.2b:wp243
Corresponding_transcriptT04B2.2b
T04B2.2c
T04B2.2a.1
T04B2.2a.2
Other_sequence (46)
Associated_featureWBsf228922
Experimental_infoRNAi_result (23)
Expr_patternExpr3701
Expr12446
Expr12447
Expr1025217
Expr1030888
Expr1155979
Expr2011880
Expr2030118
Drives_constructWBCnstr00021086
WBCnstr00036915
Construct_productWBCnstr00036915
AntibodyWBAntibody00000861
WBAntibody00000862
Microarray_results (22)
Expression_cluster (170)
Interaction (162)
WBProcessWBbiopr:00000073
Map_infoMapIVPosition4.4713Error0.000971
PositivePositive_cloneT04B2Author_evidenceRothman JR
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (12)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene