WormBase Tree Display for Gene: WBGene00001994
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| WBGene00001994 | SMap | S_parent | Sequence | F20B6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | hpk-1 | Person_evidence | WBPerson1138 | |||||
| Sequence_name | F20B6.8 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | CELE_F20B6.8 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | hpk-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 06 Mar 2018 14:36:36 | WBPerson4025 | Event | Split_into | WBGene00303101 | ||||
| Split_into | WBGene00303101 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hpk | ||||||||
| Allele (109) | |||||||||
| Strain | WBStrain00007132 | ||||||||
| WBStrain00007138 | |||||||||
| WBStrain00050617 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (32) | |||||||||
| Paralog | WBGene00003150 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003149 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016465 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00016464 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00006517 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00013727 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00185089 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | hpk-1 encodes a predicted dual-specificity protein kinase with distant homology to the vertebrate protein kinase DYRK1A and the Drosophila homolog mini-brain; RNA interference of hpk-1 does not result in any detectable phenotype; the HPK-1::GFP fusion protein is localized to the nucleus and is expressed in cleavage stage embryos. | Paper_evidence | WBPaper00005756 | |||||
| WBPaper00017919 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including autophagosome assembly; determination of adult lifespan; and response to heat. Located in nucleus. Expressed in several structures, including gonad and neurons. Used to study Parkinson's disease. Is an ortholog of human HIPK1 (homeodomain interacting protein kinase 1); HIPK2 (homeodomain interacting protein kinase 2); and HIPK3 (homeodomain interacting protein kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00042136 | ||||
| Accession_evidence | OMIM | 190685 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Apr 2013 00:00:00 | ||||||||
| Disease_relevance | Human homeodomain-interacting protein kinases (HIPK1, HIPK2, HIPK3, HIPK4) are serine/threonine kinases that phosphorylate p53, and likely promote the expression of p53 target genes; elegans hpk-1 which is orthologous to the HIPK proteins, is involved in germline proliferation in the worm; hpk-1 has been shown to have a protective effect in an elegans model for alpha-synuclein (alpha-syn) toxicity (implicated in Parkinson''s disease, and other alpha-synucleinopathies); this model consists of overexpression of human alpha-syn fused to green fluorescent protein (GFP) in body wall muscle cells, resulting in age-dependent alpha-syn misfolding in the cytoplasm; co-expression of a chaperone, TOR-2, in this system reduces alpha-syn-GFP misfolding, providing a genetic background in which the enhancement of alpha-syn misfolding is easily visualized; hpk-1 was identified as a interactor of catp-6/ATP13A2; deficiency of catp-6/ATP13A2 and its interactors, including hpk-1, exacerbates alpha-syn misfolding in the above elegans model. | Homo sapiens | Paper_evidence | WBPaper00041253 | |||||
| WBPaper00032527 | |||||||||
| Accession_evidence | OMIM | 190685 | |||||||
| 608003 | |||||||||
| 606868 | |||||||||
| 604424 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Nov 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000130 | ||||||||
| Molecular_info | Corresponding_CDS | F20B6.8a | |||||||
| F20B6.8b | |||||||||
| F20B6.8c | |||||||||
| Corresponding_CDS_history | F20B6.8d:wp264 | ||||||||
| F20B6.8e:wp264 | |||||||||
| Corresponding_transcript | F20B6.8a.1 | ||||||||
| F20B6.8b.1 | |||||||||
| F20B6.8c.1 | |||||||||
| F20B6.8c.2 | |||||||||
| F20B6.8c.3 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature (23) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr2390 | ||||||||
| Expr11203 | |||||||||
| Expr13561 | |||||||||
| Expr1019459 | |||||||||
| Expr1031159 | |||||||||
| Expr1149033 | |||||||||
| Expr2012552 | |||||||||
| Expr2030789 | |||||||||
| Drives_construct | WBCnstr00000361 | ||||||||
| WBCnstr00018061 | |||||||||
| WBCnstr00022492 | |||||||||
| WBCnstr00036533 | |||||||||
| WBCnstr00039718 | |||||||||
| Construct_product | WBCnstr00000361 | ||||||||
| WBCnstr00018061 | |||||||||
| WBCnstr00036533 | |||||||||
| WBCnstr00039718 | |||||||||
| Regulate_expr_cluster | WBPaper00049134:hpk-1(pk1393)_downregulated | ||||||||
| WBPaper00049134:hpk-1(pk1393)_upregulated | |||||||||
| WBPaper00065581:hpk-1(pk1393)_downregulated | |||||||||
| WBPaper00065581:hpk-1(pk1393)_upregulated | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (151) | |||||||||
| Interaction (180) | |||||||||
| Map_info | Map | X | Position | -7.97744 | Error | 0.028057 | |||
| Positive | Positive_clone | F20B6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4413 | |||||||
| 5585 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | Sequence connection from [Raich WB]. 02/06/12 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
