WormBase Tree Display for Gene: WBGene00002232
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WBGene00002232 | SMap | S_parent | Sequence | F11A6 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | kpc | |||||
Allele (115) | ||||||
Strain | WBStrain00035504 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (48) | ||||||
Ortholog (49) | ||||||
Paralog | WBGene00000088 | Caenorhabditis elegans | From_analysis | TreeFam | ||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00000254 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
WBGene00001172 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00017686 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
Structured_description | Concise_description | kpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129. | Paper_evidence | WBPaper00004142 | ||
WBPaper00018607 | ||||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Automated_description | Enables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model | DOID:234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8747) | |
DOID:2349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8568) | |||
DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8746) | |||
Molecular_info | Corresponding_CDS | F11A6.1a | ||||
Corresponding_CDS_history | F11A6.1b:wp245 | |||||
Corresponding_transcript | F11A6.1b | |||||
F11A6.1a.1 | ||||||
F11A6.1a.2 | ||||||
Other_sequence (36) | ||||||
Associated_feature (22) | ||||||
Experimental_info | RNAi_result | WBRNAi00116836 | Inferred_automatically | RNAi_primary | ||
WBRNAi00003363 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00089035 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00106792 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00044358 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00027714 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern (11) | ||||||
Drives_construct | WBCnstr00018109 | |||||
WBCnstr00018110 | ||||||
WBCnstr00020063 | ||||||
Construct_product (4) | ||||||
Microarray_results (39) | ||||||
Expression_cluster (198) | ||||||
Interaction (29) | ||||||
Map_info (4) | ||||||
Reference (28) | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |