mig-1 encodes one of four C. elegans Frizzled-like receptors; mig-1 was initially identified in screens for animals with defective cell migrations, and its activity is required for proper migration of the QL neuroblast and the HSN neurons.
Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance. Predicted to be located in plasma membrane. Expressed in anal depressor muscle; head muscle; and neurons. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1 and prostate carcinoma in situ. Is an ortholog of human FZD4 (frizzled class receptor 4).