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WormBase Tree Display for Variation: WBVar00088406

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Name Class

WBVar00088406NamePublic_nameky123
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005237
WBStrain00008611
WBStrain00008613
WBStrain00008614
WBStrain00008615
WBStrain00008616
WBStrain00008620
LaboratoryCX
StatusLive
AffectsGeneWBGene00004729
InteractorWBInteraction000518369
WBInteraction000518560
WBInteraction000518896
WBInteraction000518899
DescriptionPhenotypeWBPhenotype:0000002Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
RemarkmildPaper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBPhenotype:0000006Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Remarkanimals were defective in egg-layingPaper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBPhenotype:0000050Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Remarkmutants exhibited a high incidence of embryonic lethality (82% of eggs laid fail to hatch)Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBPhenotype:0000062Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Remarkanimals showed decreased viability at 25 deg C.Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBPhenotype:0000181Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Remark12% of the NSM neurons in sax-3 mutants lack the dorsal processes and 3% have a short sub-ventral process.Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0003666PATO:0000460Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Phenotype_assayGenotypezdIs13 [ tph-1p::GFP]Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
WBPhenotype:0000379Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Remarkmutants exhibited defects in head morphology producing a notched head phenotypePaper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBPhenotype:0000384Paper_evidenceWBPaper00031671
WBPaper00003760
WBPaper00040041
Curator_confirmedWBPerson2021
WBPerson712
Remark37% of NSM neurons exhibit anterior misguidance defects in sax-3 mutantsPaper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Mutants exhibited premature termination of the AWC axonsPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
Animals exhibit AVM ventral axon guidance defects. These defects can be rescued by exogenous acetylcholine.Paper_evidenceWBPaper00040041
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Affected_byMoleculeWBMol:00004765Paper_evidenceWBPaper00040041
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0003666PATO:0000460Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
WBbt:0003832PATO:0000460Paper_evidenceWBPaper00040041
Curator_confirmedWBPerson712
Phenotype_assayGenotypezdIs13 [ tph-1p::GFP]Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
WBPhenotype:0000471Paper_evidenceWBPaper00026825
Curator_confirmedWBPerson2021
RemarkIn the absence of sax-3, ALML/R neurons stopped prematurelyPaper_evidenceWBPaper00026825
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005406PATO:0000460Paper_evidenceWBPaper00026825
Curator_confirmedWBPerson2021
Phenotype_assayGenotypezdIs5Paper_evidenceWBPaper00026825
Curator_confirmedWBPerson2021
WBPhenotype:0000565Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
RemarkmildPaper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBPhenotype:0000633Paper_evidenceWBPaper00045955
Curator_confirmedWBPerson557
RemarkBranch defects scored in PLM neuron.Paper_evidenceWBPaper00045955
Curator_confirmedWBPerson557
PenetranceLowPaper_evidenceWBPaper00045955
Curator_confirmedWBPerson557
WBPhenotype:0000882Paper_evidenceWBPaper00055911
Curator_confirmedWBPerson14810
WBPhenotype:0001140Paper_evidenceWBPaper00050480
Curator_confirmedWBPerson712
Remarksax-3(ky123) mutants showed weak but significant defects in both AQR and PQR migrationPaper_evidenceWBPaper00050480
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0003927PATO:0000460Paper_evidenceWBPaper00050480
Curator_confirmedWBPerson712
WBbt:0004096PATO:0000460Paper_evidenceWBPaper00050480
Curator_confirmedWBPerson712
WBPhenotype:0001224Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Remarkanteriorly-misdirected axons, in addition sax-3 mutants exhibited defects in two long-range cell migrations, the posterior migration of the CAN neurons and the anterior migration of the HSN motor neuronsPaper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005394PATO:0000460Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBbt:0006827PATO:0000460Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBbt:0006830PATO:0000460Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Phenotype_assayGenotypekyIs4[ceh-23::GFP] or kyIs128[str-3::GFP]Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBPhenotype:0001227Paper_evidenceWBPaper00027335
Curator_confirmedWBPerson48
RemarkRay commissures absent: R1.Paper_evidenceWBPaper00027335
Curator_confirmedWBPerson48
PenetranceIncompletePaper_evidenceWBPaper00027335
Curator_confirmedWBPerson48
Range1414Paper_evidenceWBPaper00027335
Curator_confirmedWBPerson48
WBPhenotype:0001310Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Remark19% of mutants exhibit a morphology so abnormal, with NSM cell bodies frequently misplacedPaper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0003666PATO:0000460Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Phenotype_assayGenotypezdIs13 [ tph-1p::GFP]Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
WBPhenotype:0001434Paper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
Remarkanimals were defective in chemotaxisPaper_evidenceWBPaper00003665
Curator_confirmedWBPerson712
WBPhenotype:0001661Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
RemarkAWC specific str-2 expression Is altered: no str-2 expression in AWCPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005672PATO:0000460Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
WBPhenotype:0001767Paper_evidenceWBPaper00032413
Curator_confirmedWBPerson2021
Remarksax-3/Robo is involved in routing all DA/DB motor neuronsPaper_evidenceWBPaper00032413
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005278PATO:0000460Paper_evidenceWBPaper00032413
Curator_confirmedWBPerson2021
WBbt:0005274PATO:0000460Paper_evidenceWBPaper00032413
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000679Paper_evidenceWBPaper00037766
Curator_confirmedWBPerson712
RemarkThe localization of SRGP-1::GFP in the sax-3-null background was identical to wild-type embryos. Deletion of the F-BAR domain of the abolished SRGP-1::GFP whereas the 200 aa immediately C terminal to the F-BAR domain was required for full junctional targeting.Paper_evidenceWBPaper00037766
Curator_confirmedWBPerson712
WBPhenotype:0001652Paper_evidenceWBPaper00032446
Curator_confirmedWBPerson2021
WBPhenotype:0001660Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
RemarkNo disruption of ASE asymmetry (as seen with lim-6 reporters)Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Phenotype_assayGenotypeotIs114, otIs6Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
ReferenceWBPaper00040041
WBPaper00031671
WBPaper00032446
WBPaper00006052
WBPaper00032413
WBPaper00027335
WBPaper00015626
WBPaper00003665
WBPaper00003760
WBPaper00026825
WBPaper00010168
WBPaper00018942
WBPaper00037766
WBPaper00045955
WBPaper00050480
WBPaper00055911
WBPaper00065184
Remarkky123 deletes the signal peptide and first exonPaper_evidenceWBPaper00002997
MethodAllele