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WormBase Tree Display for Variation: WBVar00252138

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Name Class

WBVar00252138NamePublic_nametm3463
Other_nameCE32634:p.Leu97GlyfsTer13
F21H12.1.1:c.288_1240del
HGVSgCHROMOSOME_II:g.6098306_6099310del
Sequence_detailsSMapS_parentSequenceF21H12
Flanking_sequencestgctgacaactccattgcaatgtttgatgttggacatagaaaatgcagacaacgatcaaa
Mapping_targetF21H12
Source_location7CHROMOSOME_II60983056099311Inferred_automaticallyNational_Bioresource_Project
Type_of_mutationDeletion
PCR_producttm3463_external
tm3463_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryFX
AuthorMitani S
DB_infoDatabaseNational_Bioresource_Projectseq3463
NBP_allele
StatusLive
AffectsGeneWBGene00017683
TranscriptF21H12.1.1 (11)
IsolationMutagenTMP/UV
GeneticsMapII
DescriptionPhenotypeWBPhenotype:0000032Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComments to the National Bioresource Project of Japan: Dr.J.M. Schumacher: SckPerson_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceJS
WBPhenotype:0000050Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
RemarkMutant produce 16% embryonic lethality at 25 deg C.Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00038409
Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComments to the National Bioresource Project of Japan: Dr.J.M. Schumacher: reduced brood size.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceJS
Average brood size 111 at 20 deg C, 54 at 25 deg C.Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
WBPhenotype:0000275Paper_evidenceWBPaper00060474
Curator_confirmedWBPerson8633
RemarkFigure 1, larval arrest and lifespan shortening were observed upon UV treatment.Paper_evidenceWBPaper00060474
Curator_confirmedWBPerson8633
WBPhenotype:0000696Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComments to the National Bioresource Project of Japan: Dr.J.M. Schumacher: EvlPerson_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceJS
WBPhenotype:0000816Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkComment to the NBP from Dr. O. Hobert: ASE development defective.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceOH
EQ_annotationsAnatomy_termWBbt:0005663PATO:0000460Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
WBPhenotype:0002078Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
RemarkAt the eight-cell stage as well as at post-gastrulation, the H3K4me3 mark is undetectable in mutants compared to N2. H3K4me3 is undetectable in Western blot analysis.Paper_evidenceWBPaper00038409
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000062Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
RemarkClassified as homozygous viable by the National Bioresource Project of Japan.Person_evidenceWBPerson7743
Curator_confirmedWBPerson712
Laboratory_evidenceFX
ReferenceWBPaper00038409
WBPaper00060474
Remark16052/16053-17057/17058 (1005 bp deletion)
This knockout was generated by the National Bioresource Project, Tokyo, Japan, which is part of the International C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use.Paper_evidenceWBPaper00041807
MethodNBP_knockout_allele