WormBase Tree Display for Variation: WBVar00275220

WBVar00275220 Name: Public_name: x26
    Other_name: CE30706:p.Cys151Tyr
      Y110A7A.3.1:c.452G>A
    HGVSg: CHROMOSOME_I:g.5146075G>A
  Sequence_details: SMap: S_parent: Sequence: Y110A7A
    Flanking_sequences: aaaacttcctaaatttatatttcagcatgt ccaaatcgacgttgaattctttccatttga
    Mapping_target: Y110A7A
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00024530
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040925
    Laboratory: ZZ
    Status: Live
  Affects: Gene: WBGene00006797
    Transcript: Y110A7A.3.1 (12)
  Isolation: Mutagen: EMS Paper_evidence: WBPaper00024530
  Genetics: Interpolated_map_position: I -0.351746
  Description: Phenotype: WBPhenotype:0000421 Paper_evidence: WBPaper00000484
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: Partial resistance at 16C. Complete resistance at 25C. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
          slight levamisole resistance Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00000484
              Person_evidence: WBPerson261
              Curator_confirmed: WBPerson2021
                WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1mM levamisole Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
          Temperature: 16C, 25C Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000554 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Mutants succumb to osmotic shock. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
          Range: 30 30 Paper_evidence: WBPaper00000484
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 10mM HEPES (pH 7.0), 0.25 per cent TWEEN 20. Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000643 Paper_evidence: WBPaper00000484
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: Conditional Unc at 25C Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
          almost normal movement Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 16C, 25C Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001700 Paper_evidence: WBPaper00034750
        Curator_confirmed: WBPerson2021
        Remark: Mutants show defects in swimming Paper_evidence: WBPaper00034750
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0001578 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Animals are not resistant to the cholinergic agonist carbachol. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1mM carbachol Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
  Disease_info: Models_disease: DOID:3635
    Models_disease_in_annotation: WBDOannot00000869
      WBDOannot00000870
      WBDOannot00000873
      WBDOannot00000874
      WBDOannot00000875
  Reference: WBPaper00000484
    WBPaper00018321
    WBPaper00023610
    WBPaper00034750
  Method: Substitution_allele