| WBGene00000088 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F32A7 |
| Identity | Version | 1 |
| | Name | CGC_name | aex-5 | Person_evidence | WBPerson655 |
| | | Sequence_name | F32A7.6 |
| | | Molecular_name | F32A7.6 |
| | | | F32A7.6.1 |
| | | | CE28554 |
| | | Other_name | kpc-3 |
| | | | kpc-5 |
| | | | CELE_F32A7.6 | Accession_evidence | NDB | BX284601 |
| | | Public_name | aex-5 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | aex |
| | Allele (170) |
| | Legacy_information | [Jim Thomas] Defecation defective, moderate to severe constipation, expulsion muscle contraction (Exp) missing in about 9 of 10 defecation cycles, anterior body contraction (aBoc) usually missing as well, adult males unaffected and mate well. |
| | | See also sa23, sa41, sa42, sa43 |
| | | [C.elegansII] sa23 : defecation defective, moderate to severe constipation, expulsion muscle contraction (Exp) missing in about 9 of 10 defecation cycles, anterior body contraction (aBoc) usually missing as well, adult males unaffected and mate well. OA3: sa41, sa42, sa43 (all similar) [Thomas 1990; JT] |
| | Strain | WBStrain00022773 |
| | RNASeq_FPKM (74) |
| | GO_annotation (29) |
| | Ortholog (47) |
| | Paralog | WBGene00001172 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000254 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002232 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00017686 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | an ortholog of calcium-dependent serine endoproteinases, the kex2/subtilisin-like proprotein convertase that affects defecation cycle and anterior body contractions; and is expressed in all muscle cells except pharyngeal muscles. | Paper_evidence | WBPaper00004142 |
| | | | | Curator_confirmed | WBPerson480 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables serine-type endopeptidase activity. Involved in several processes, including neuropeptide processing; positive regulation of synaptic assembly at neuromuscular junction; and positive regulation of transport. Located in extracellular space. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F32A7.6 |
| | Corresponding_CDS_history | F32A7.6:wp56 |
| | Corresponding_transcript | F32A7.6.1 |
| | Other_sequence | Oden_isotig22904 |
| | | Acan_isotig14016 |
| | | Tcir_isotig22927 |
| | | CJC17003_1 |
| | Associated_feature | WBsf649782 |
| | | WBsf220659 |
| | | WBsf220660 |
| Experimental_info | RNAi_result (36) |
| | Expr_pattern | Expr1010377 |
| | | Expr1149978 |
| | | Expr2009250 |
| | | Expr2027487 |
| | Drives_construct | WBCnstr00037741 |
| | Construct_product | WBCnstr00005315 |
| | | WBCnstr00007723 |
| | | WBCnstr00037741 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046805:P-granule-RNAi_downregulated_Set1 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056034:pals-25(jy9)_upregulated |
| | | WBPaper00056039:ptl-1(ok621)_upregulated |
| | | WBPaper00056073:NHR-86_interacting_promoter |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056218:daf-16(mu86)_downregulated_Day7 |
| | | WBPaper00056284:ints-4(RNAi)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057136:yap-1(ys38)_downregulated |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058678:DAF-12_upregulated_PVD |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059175:hlh-17p-XBP-1_upregulated |
| | | WBPaper00059194:KLF-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060951:mrpl-2(osa3)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061340:FLP |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061466:nath-10(icb99)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:gtl-1-hum-8_16432 |
| | | WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:ASG_enriched |
| | | WBPaper00061651:Rectal_gland_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064735:bet-1B(OE)_vs_N2_upregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065734:unc-25(e156)_upregulated |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:30_0 |
| | | WBPaper00065841:39_0 |
| | | WBPaper00065841:39_1 |
| | | WBPaper00065841:39_2 |
| | | WBPaper00065841:138_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | cgc4489_group_8 |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_downregulated |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032948:StarveUp1 |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00038060:SUMO-1_downregulated |
| | | WBPaper00038172:tax-6null_down_regulated |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | [cgc6390]:Cluster_C |
| | Interaction | WBInteraction000001570 |
| | | WBInteraction000028975 |
| | | WBInteraction000165455 |
| | | WBInteraction000519683 |
| | | WBInteraction000524187 |
| | | WBInteraction000557476 |
| | | WBInteraction000557477 |
| | | WBInteraction000557478 |
| | WBProcess | WBbiopr:00000010 |
| Map_info | Map | I | Position | 27.9582 | Error | 0.002256 |
| | Well_ordered |
| | Positive | Positive_clone | F32A7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 1479 |
| | | | 1697 |
| | | Pos_neg_data | 4754 |
| | | | 4755 |
| | | | 4756 |
| | | | 4757 |
| | | | 4758 |
| | | | 4759 |
| | | | 4760 |
| Reference (34) |
| Remark | Sequence connection from [Thacker C] |
| | old_name kpc-5 becomes new_name aex-5 from [Thacker C]. |
| Method | Gene |
