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WormBase Tree Display for Gene: WBGene00000464

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Name Class

WBGene00000464SMapS_parentSequenceY54F10AM
IdentityVersion2
NameCGC_nameceh-44Person_evidenceWBPerson83
Sequence_nameY54F10AM.4
Molecular_nameY54F10AM.4
Y54F10AM.4.1
CE27288
Other_namecone-1Person_evidenceWBPerson260
Laboratory_evidenceOH
Remarkcone-1 is the gene name from transcripts b and c, as these form a gene fuctionally distinct from the a transcript
CELE_Y54F10AM.4Accession_evidenceNDBBX284603
Public_nameceh-44
DB_infoDatabaseAceViewgene3D635
WormQTLgeneWBGene00000464
WormFluxgeneWBGene00000464
NDBlocus_tagCELE_Y54F10AM.4
PanthergeneCAEEL|WormBase=WBGene00000464|UniProtKB=Q9BL02
familyPTHR14043
NCBIgene80510351
RefSeqproteinNM_065175.9
SwissProtUniProtAccQ9BL02
UniProt_GCRPUniProtAccQ9BL02
OMIMgene610648
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
204 Jan 2022 01:23:28WBPerson1983EventSplit_intoWBGene00306126
Split_intoWBGene00306126
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classceh
Allele (353)
Strain (13)
RNASeq_FPKM (74)
GO_annotation (15)
Contained_in_operonCEOP3078
Ortholog (42)
ParalogWBGene00000444Caenorhabditis elegansFrom_analysisTreeFam
WBGene00000459Caenorhabditis elegansFrom_analysisTreeFam
WBGene00000460Caenorhabditis elegansFrom_analysisTreeFam
WBGene00306126Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionceh-44 encodes at least three proteins via alternative splicing; the CEH-44A protein is an ortholog of the CUX class of CUT homeodomain proteins, expressed in early embryos (mostly anterior in the comma stage), in the larval nerve ring and the adult gonad; the CUX class includes Drosophila CUT, human CUTL1 and human CUTL2; ceh-44 is a complex gene, in which two alternatively spliced protein products completely lack the homeodomain and cut domain, and instead form a different protein, CASP; in vertebrates, this alternative splicing also occurs, while in Drosophila Casp as been lost; CASP proteins are also found in plants and fungi (though not associated with homeodomains); like its orthologs, CEH-44A has three cut domains upstream of the homeodomain; the cut domain is a DNA binding domain.Paper_evidenceWBPaper00005164
WBPaper00005654
Person_evidenceWBPerson83
Curator_confirmedWBPerson13481
WBPerson1843
Date_last_updated26 Jun 2011 00:00:00
Automated_descriptionPredicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in head muscle; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including developmental and epileptic encephalopathy 67; gastrointestinal system cancer (multiple); and insulinoma. Is an ortholog of human CUX2 (cut like homeobox 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3892Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2557)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2557)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2557)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2557)
DOID:0112203Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:19347)
Molecular_infoCorresponding_CDSY54F10AM.4
Corresponding_CDS_historyY54F10AM.4b:wp91
Y54F10AM.4b:wp283
Y54F10AM.4c:wp283
Corresponding_transcriptY54F10AM.4.1
Associated_feature (21)
Transcription_factorWBTranscriptionFactor000292
Experimental_infoRNAi_resultWBRNAi00106736Inferred_automaticallyRNAi_primary
WBRNAi00057401Inferred_automaticallyRNAi_primary
WBRNAi00107381Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00002360
WBCnstr00002361
WBCnstr00002788
WBCnstr00012875
Microarray_results (16)
Expression_cluster (141)
SAGE_tag (15)
Interaction (58)
Map_infoMapIIIPosition-12.9684Error0.140862
PositivePositive_cloneY54F10AMInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4306
4846
4812
Pseudo_map_position
Reference (16)
RemarkSequence connection from [Pujol N]. krb 13/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
ceh-44 had 3 isoforms, a,b and c. Only the a isoform is a homeobox gene (hence ceh-44) - i.e. only the a-isoform specific exons have the CUT and homeodomain thats the key feature of this protein. The b and c isoforms are a functionally TOTALLY different protein - a Golgi associated protein called CASP. This gene structure is conserved in vertebrates (and it is in vertebrates where this protein has been shown to be a Golgi protein). Thomas Burglin has written about this. See Fig.6 in Burglin et al Int. J. Dev. Biol. 46: 115-123 (2002) Loss and gain of domains during evolution of cut superclass homeobox genes. I would like to argue to call the b and c isoforms (Y54F10AM.4b and Y54F10AM.4c) = cone-1. Decided to rename these Isoforms to have a unique WBGene accession and a new sequence name Y54F10AM.16.Person_evidenceWBPerson260
Curator_confirmedWBPerson1983
MethodGene