WormBase Tree Display for Gene: WBGene00000510
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| WBGene00000510 | Evidence | Paper_evidence | WBPaper00005916 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C52B9 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cka-2 | |||||||
| Sequence_name | C52B9.1 | ||||||||
| Molecular_name | C52B9.1a | ||||||||
| C52B9.1a.1 | |||||||||
| CE27113 | |||||||||
| C52B9.1b | |||||||||
| CE38493 | |||||||||
| C52B9.1b.1 | |||||||||
| C52B9.1b.2 | |||||||||
| Other_name | CELE_C52B9.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | cka-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cka | ||||||||
| Allele (84) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00000509 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000515 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000512 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000513 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000511 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000514 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cka-2 encodes an isoform of choline kinase whose activity has beenverified in vitro; CKA-1 and CKA-2 comprise a related group ('A') ofcholine kinases; purified CKA-2 is dimeric, requires 1 mM Mg(2+) foroptimal activity, and has a strong preference for choline overethanolamine; CKA-2 has a pH optimum of 10 and a k(cat) of 74/s, close tothe maximum rate observed for yeast and rat enzymes. | Paper_evidence | WBPaper00005916 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 11 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables choline kinase activity. Involved in CDP-choline pathway. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including colon adenoma; megaconial type congenital muscular dystrophy; narcolepsy; and recurrent hypersomnia. Is an ortholog of human CHKA (choline kinase alpha). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:8619 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1938) | ||||
| DOID:8986 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1938) | ||||||
| DOID:0050912 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1937) | ||||||
| DOID:9884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1938) | ||||||
| DOID:0110632 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1938) | ||||||
| DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1938) | ||||||
| Molecular_info | Corresponding_CDS | C52B9.1a | |||||||
| C52B9.1b | |||||||||
| Corresponding_CDS_history | C52B9.1:wp142 | ||||||||
| Corresponding_transcript | C52B9.1a.1 | ||||||||
| C52B9.1b.1 | |||||||||
| C52B9.1b.2 | |||||||||
| Other_sequence (59) | |||||||||
| Associated_feature | WBsf648006 | ||||||||
| WBsf235568 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00083978 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00094930 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043009 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012292 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030072 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1015717 | ||||||||
| Expr1030303 | |||||||||
| Expr1146973 | |||||||||
| Expr2010025 | |||||||||
| Expr2028266 | |||||||||
| Drives_construct | WBCnstr00037488 | ||||||||
| Construct_product | WBCnstr00037488 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (39) | |||||||||
| Map_info | Map | X | Position | -7.79874 | Error | 0.000946 | |||
| Positive | Positive_clone | C52B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5504 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005916 | ||||||||
| WBPaper00006487 | |||||||||
| WBPaper00034497 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042257 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
