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WormBase Tree Display for Gene: WBGene00000793

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Name Class

WBGene00000793EvidenceAccession_evidenceEMBLAB081595
SMapS_parentSequenceY41C4A
IdentityVersion1
NameCGC_namecrh-1Person_evidenceWBPerson268
Sequence_nameY41C4A.4
Molecular_name (21)
Other_nameCELE_Y41C4A.4Accession_evidenceNDBBX284603
Public_namecrh-1
DB_infoDatabaseAceViewgene3M781
WormQTLgeneWBGene00000793
WormFluxgeneWBGene00000793
NDBlocus_tagCELE_Y41C4A.4
PanthergeneCAEEL|WormBase=WBGene00000793|UniProtKB=D0Z5N1
familyPTHR45879
NCBIgene176597
RefSeqproteinNM_001027688.6
NM_001027691.4
NM_001027690.4
NM_001268206.3
NM_001027689.3
NM_001027692.4
NM_001268207.3
SwissProtUniProtAccQ9U2I0
TREEFAMTREEFAM_IDTF106464
UniProt_GCRPUniProtAccQ9U2I0
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcrh
Allele (986)
StrainWBStrain00040751
WBStrain00035398
WBStrain00055558
RNASeq_FPKM (74)
GO_annotation (18)
Ortholog (45)
ParalogWBGene00000222Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002783Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00016162Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptioncrh-1 encodes a homolog of the cyclic AMP-response element binding protein (CREB); crh-1 is involved in the transcription of CRE-sequence dependant genes activated by a CaM kinase cascade; crh-1 is required in the bilateral thermosensory neuron AFD, for a memory-related behaviour and for response to tap (nonlocalized mechanosensory stimulation) and tap habituation; crh-1 appears to be ubiquitously expressed.Paper_evidenceWBPaper00005563
WBPaper00029055
WBPaper00039855
WBPaper00039821
Curator_confirmedWBPerson1843
WBPerson324
Date_last_updated02 Dec 2013 00:00:00
Automated_descriptionEnables identical protein binding activity and transcription coactivator binding activity. Involved in determination of adult lifespan; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Expressed in several structures, including germ line; gonad; head ganglion; intestine; and neurons. Human ortholog(s) of this gene implicated in Pick's disease and schizophrenia. Is an ortholog of human ATF1 (activating transcription factor 1); CREB1 (cAMP responsive element binding protein 1); and CREM (cAMP responsive element modulator).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:9976Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2345)
DOID:0050741Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2345)
DOID:11870Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2345)
DOID:9975Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2345)
DOID:5419Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2345)
Molecular_infoCorresponding_CDSY41C4A.4a
Y41C4A.4b
Y41C4A.4c
Y41C4A.4d
Y41C4A.4e
Y41C4A.4f
Y41C4A.4g
Corresponding_CDS_historyY41C4A.4a:wp89
Y41C4A.4b:wp89
Y41C4A.4c:wp89
Corresponding_transcriptY41C4A.4a.1
Y41C4A.4b.1
Y41C4A.4c.1
Y41C4A.4d.1
Y41C4A.4e.1
Y41C4A.4f.1
Y41C4A.4g.1
Other_sequence (69)
Associated_feature (43)
Transcription_factorWBTranscriptionFactor000257
Experimental_infoRNAi_resultWBRNAi00056358Inferred_automaticallyRNAi_primary
WBRNAi00095782Inferred_automaticallyRNAi_primary
WBRNAi00036995Inferred_automaticallyRNAi_primary
WBRNAi00006490Inferred_automaticallyRNAi_primary
WBRNAi00116042Inferred_automaticallyRNAi_primary
WBRNAi00115794Inferred_automaticallyRNAi_primary
WBRNAi00056360Inferred_automaticallyRNAi_primary
WBRNAi00087890Inferred_automaticallyRNAi_primary
WBRNAi00006495Inferred_automaticallyRNAi_primary
Expr_pattern (12)
Drives_constructWBCnstr00008257
WBCnstr00012859
WBCnstr00038398
WBCnstr00038399
WBCnstr00041558
Construct_product (13)
Regulate_expr_clusterWBPaper00038172:crh-1null_down_regulated
WBPaper00038172:crh-1null_up_regulated
WBPaper00059816:crh-1(n3315)_downrgulated
WBPaper00059816:crh-1(n3315)_uprgulated
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062440:crh-1(n3315)_upregulated
WBPaper00062440:crh-1(syb385)_downregulated
WBPaper00062440:crh-1(syb385)_upregulated
AntibodyWBAntibody00001853
Microarray_results (61)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00033070:Elbe_upregulated
WBPaper00035269:cde-1_regulated
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00042194:nhr-114(RNAi)_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00046303:P.aeruginosa_upregulated_protein
WBPaper00048923:Aging_regulated
WBPaper00048988:daf-16(mu86)_downregulated_neuron
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_upregulated
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:nucleus_specific
WBPaper00051404:alg-5(ram2)_downregulated
WBPaper00051558:aging_regulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053289:DREAM-target
WBPaper00053599:female_vs_male_downregulated
WBPaper00053606:N2_vs_elt-7(tm840)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055648:germline_expressed
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058725:sftb-1(cer39)_upregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059987:Wounding_upregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061203:spr-1(ok2144)_downregulated
WBPaper00061527:C38C3.6-npr-7
WBPaper00061527:pptr-1-F08D12.1
WBPaper00062103:neuron_enriched
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064505:tamoxifen_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065841:135_0
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
cgc4489_group_14
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031832:slr-2_regulated
WBPaper00034661:AgNPs_downregulated
WBPaper00036123:Atrazine_regulated
WBPaper00037695:WC_5-day
WBPaper00038172:crh-1null_up_regulated
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00042067:Cu2+_upregulated_WT
WBPaper00045673:colistin_upregulated
WBPaper00045960:L1-L4-lethargus_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00048989:N2_rapamycin_upregulated
Interaction (63)
WBProcessWBbiopr:00000121
Map_infoMapIIIPosition11.752Error0.036866
PositivePositive_cloneY41C4AInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4239
4497
Pseudo_map_position
Reference (94)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene