WormBase Tree Display for Gene: WBGene00001077
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| WBGene00001077 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dpy-18 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y47D3B.10 | ||||||||
| Molecular_name | Y47D3B.10 | ||||||||
| Y47D3B.10.1 | |||||||||
| CE20261 | |||||||||
| Other_name | phy-1 | ||||||||
| T28D6.1 | Paper_evidence | WBPaper00005747 | |||||||
| CELE_Y47D3B.10 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | dpy-18 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dpy | ||||||||
| Reference_allele | WBVar00143150 | ||||||||
| Allele (101) | |||||||||
| Possibly_affected_by | WBVar02158838 | ||||||||
| Legacy_information | e364amber : medium dumpy. ES3 (adult) ES2 (larvae). ME2. NA3 (e499 e1270). | ||||||||
| See also e1862 | |||||||||
| [C.elegansII] e364amb : medium dumpy. ES3 (adult) ES2 (larvae). ME2. Males have abnormal lumpy rays (Ram) at 25C. OA>10: e499, e1270, e1862,s361fdi, s1304 (induced on eT1), bx26 (Ram at 25C), h662. [Brenner 1974; Baird and Emmons 1990; PB] | |||||||||
| Strain (219) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (60) | |||||||||
| Paralog | WBGene00015773 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00004026 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00012815 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00004025 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00077688 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | dpy-18 encodes a catalytic alpha subunit of collagen prolyl 4-hydroxylase (P4H) orthologous to human P4H alpha (I) isoform (OMIM: 176710), an alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; dpy-18 has a critical role in hydroxylation of cuticle collagens during collagen synthesis; dpy-18, in complex with phy-2, is essential for the survival of the C. elegans; dpy-18 mutations alone result in a mild dumpy phenotype; expressed dpy-18 and ten-1 act in parallel influencing the connection between epidermis and muscle during embryonic development; deletion of dpy-18 causes aggregation of collagen IV in body wall muscles in elongated embryos and triggers the loss of tissue integrity in ten-1 mutants; dpy-18 is expressed throughout the hypodermis, head and posterior neurons. | Paper_evidence | WBPaper00004203 | |||||
| WBPaper00031524 | |||||||||
| WBPaper00039988 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 18 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables procollagen-proline 4-dioxygenase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; embryo development; and embryonic body morphogenesis. Located in endoplasmic reticulum. Expressed in hypodermis; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in myopia. Is an ortholog of human P4HA1 (prolyl 4-hydroxylase subunit alpha 1) and P4HA2 (prolyl 4-hydroxylase subunit alpha 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11830 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8547) | ||||
| Molecular_info | Corresponding_CDS | Y47D3B.10 | |||||||
| Corresponding_transcript | Y47D3B.10.1 | ||||||||
| Other_sequence (83) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00056767 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00115627 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027622 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026722 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094817 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065822 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094816 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009344 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019394 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1085 | ||||||||
| Expr1928 | |||||||||
| Expr1931 | |||||||||
| Expr12145 | |||||||||
| Expr1012505 | |||||||||
| Expr1030685 | |||||||||
| Expr1160222 | |||||||||
| Expr1200375 | |||||||||
| Expr2011060 | |||||||||
| Expr2029297 | |||||||||
| Drives_construct | WBCnstr00008961 | ||||||||
| WBCnstr00010073 | |||||||||
| WBCnstr00010524 | |||||||||
| WBCnstr00020362 | |||||||||
| WBCnstr00037095 | |||||||||
| Construct_product | WBCnstr00008961 | ||||||||
| WBCnstr00008962 | |||||||||
| WBCnstr00008963 | |||||||||
| WBCnstr00010073 | |||||||||
| WBCnstr00037095 | |||||||||
| Antibody | WBAntibody00000539 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (232) | |||||||||
| Interaction (111) | |||||||||
| WBProcess | WBbiopr:00000124 | ||||||||
| Map_info | Map | III | Position | 8.85117 | Error | 0.054776 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | tDp1 | |||||||
| mT1 | |||||||||
| Positive_clone | Y47D3B | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point (58) | ||||||||
| Multi_point (145) | |||||||||
| Pos_neg_data (11) | |||||||||
| Landmark_gene | |||||||||
| Reference (127) | |||||||||
| Method | Gene |
