WormBase Tree Display for Gene: WBGene00001077

WBGene00001077 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: dpy-18 Person_evidence: WBPerson261
      Sequence_name: Y47D3B.10
      Molecular_name: Y47D3B.10
        Y47D3B.10.1
        CE20261
      Other_name: phy-1
        T28D6.1 Paper_evidence: WBPaper00005747
        CELE_Y47D3B.10 Accession_evidence: NDB BX284603
      Public_name: dpy-18
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dpy
    Reference_allele: WBVar00143150
    Allele (101)
    Possibly_affected_by: WBVar02158838
    Legacy_information: e364amber : medium dumpy. ES3 (adult) ES2 (larvae). ME2. NA3 (e499 e1270).
      See also e1862
      [C.elegansII] e364amb : medium dumpy. ES3 (adult) ES2 (larvae). ME2. Males have abnormal lumpy rays (Ram) at 25C. OA>10: e499, e1270, e1862,s361fdi, s1304 (induced on eT1), bx26 (Ram at 25C), h662. [Brenner 1974; Baird and Emmons 1990; PB]
    Strain: WBStrain00040750
      WBStrain00022583
      WBStrain00022592
      WBStrain00041146
      WBStrain00023901
      WBStrain00027198
      WBStrain00027214
      WBStrain00027215
      WBStrain00027382
      WBStrain00027612
      WBStrain00033310
      WBStrain00033509
      WBStrain00040749
      WBStrain00000292
      WBStrain00000424
      WBStrain00000419
      WBStrain00000511
      WBStrain00000512
      WBStrain00000513
      WBStrain00000514
      WBStrain00000515
      WBStrain00000517
      WBStrain00000518
      WBStrain00000519
      WBStrain00000520
      WBStrain00000521
      WBStrain00000522
      WBStrain00000523
      WBStrain00000524
      WBStrain00000525
      WBStrain00000526
      WBStrain00000527
      WBStrain00000528
      WBStrain00000530
      WBStrain00000531
      WBStrain00000535
      WBStrain00000536
      WBStrain00000537
      WBStrain00000538
      WBStrain00000539
      WBStrain00000540
      WBStrain00000543
      WBStrain00000544
      WBStrain00000545
      WBStrain00000546
      WBStrain00000547
      WBStrain00000548
      WBStrain00000549
      WBStrain00000585
      WBStrain00000586
      WBStrain00000587
      WBStrain00000588
      WBStrain00000589
      WBStrain00000590
      WBStrain00000591
      WBStrain00000592
      WBStrain00000593
      WBStrain00000594
      WBStrain00000595
      WBStrain00000596
      WBStrain00000597
      WBStrain00000598
      WBStrain00000599
      WBStrain00000600
      WBStrain00000601
      WBStrain00000602
      WBStrain00000603
      WBStrain00000604
      WBStrain00000605
      WBStrain00000607
      WBStrain00000608
      WBStrain00000609
      WBStrain00000610
      WBStrain00000611
      WBStrain00000612
      WBStrain00000613
      WBStrain00000614
      WBStrain00000615
      WBStrain00000616
      WBStrain00000617
      WBStrain00000618
      WBStrain00000619
      WBStrain00000620
      WBStrain00000621
      WBStrain00000622
      WBStrain00000623
      WBStrain00000624
      WBStrain00000625
      WBStrain00000631
      WBStrain00000632
      WBStrain00000633
      WBStrain00000634
      WBStrain00000635
      WBStrain00000636
      WBStrain00000637
      WBStrain00000638
      WBStrain00000639
      WBStrain00000640
      WBStrain00000641
      WBStrain00000642
      WBStrain00000643
      WBStrain00000644
      WBStrain00000645
      WBStrain00000646
      WBStrain00000647
      WBStrain00000648
      WBStrain00000649
      WBStrain00000650
      WBStrain00000651
      WBStrain00000652
      WBStrain00000653
      WBStrain00000654
      WBStrain00000658
      WBStrain00000659
      WBStrain00000676
      WBStrain00000677
      WBStrain00000678
      WBStrain00000679
      WBStrain00000680
      WBStrain00000681
      WBStrain00000682
      WBStrain00000683
      WBStrain00000684
      WBStrain00000685
      WBStrain00000686
      WBStrain00000687
      WBStrain00000688
      WBStrain00000689
      WBStrain00000690
      WBStrain00000691
      WBStrain00000692
      WBStrain00000693
      WBStrain00000694
      WBStrain00000695
      WBStrain00000696
      WBStrain00000697
      WBStrain00000698
      WBStrain00000699
      WBStrain00000700
      WBStrain00000701
      WBStrain00000702
      WBStrain00000703
      WBStrain00000704
      WBStrain00000705
      WBStrain00000706
      WBStrain00000707
      WBStrain00000709
      WBStrain00000710
      WBStrain00000711
      WBStrain00000712
      WBStrain00000713
      WBStrain00000714
      WBStrain00000715
      WBStrain00000716
      WBStrain00000717
      WBStrain00000719
      WBStrain00000720
      WBStrain00000721
      WBStrain00000722
      WBStrain00000723
      WBStrain00000724
      WBStrain00000725
      WBStrain00000726
      WBStrain00000727
      WBStrain00000728
      WBStrain00000729
      WBStrain00000730
      WBStrain00000731
      WBStrain00000732
      WBStrain00000734
      WBStrain00000735
      WBStrain00000736
      WBStrain00000737
      WBStrain00000738
      WBStrain00000739
      WBStrain00000742
      WBStrain00000743
      WBStrain00000744
      WBStrain00000745
      WBStrain00000746
      WBStrain00000747
      WBStrain00000748
      WBStrain00000751
      WBStrain00000818
      WBStrain00003938
      WBStrain00003943
      WBStrain00003974
      WBStrain00003977
      WBStrain00003986
      WBStrain00003988
      WBStrain00003989
      WBStrain00003995
      WBStrain00004366
      WBStrain00004371
      WBStrain00004388
      WBStrain00004397
      WBStrain00004154
      WBStrain00004693
      WBStrain00004750
      WBStrain00004790
      WBStrain00004952
      WBStrain00004954
      WBStrain00004990
      WBStrain00004999
      WBStrain00005641
      WBStrain00005642
      WBStrain00006185
      WBStrain00007127
      WBStrain00007147
      WBStrain00007149
      WBStrain00007150
      WBStrain00007250
      WBStrain00007744
      WBStrain00007731
      WBStrain00007732
      WBStrain00007733
      WBStrain00047378
      WBStrain00047379
      WBStrain00050739
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (60)
    Paralog: WBGene00015773 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00004026 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00012815 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00004025 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00077688 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: dpy-18 encodes a catalytic alpha subunit of collagen prolyl 4-hydroxylase (P4H) orthologous to human P4H alpha (I) isoform (OMIM: 176710), an alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; dpy-18 has a critical role in hydroxylation of cuticle collagens during collagen synthesis; dpy-18, in complex with phy-2, is essential for the survival of the C. elegans; dpy-18 mutations alone result in a mild dumpy phenotype; expressed dpy-18 and ten-1 act in parallel influencing the connection between epidermis and muscle during embryonic development; deletion of dpy-18 causes aggregation of collagen IV in body wall muscles in elongated embryos and triggers the loss of tissue integrity in ten-1 mutants; dpy-18 is expressed throughout the hypodermis, head and posterior neurons. Paper_evidence: WBPaper00004203
            WBPaper00031524
            WBPaper00039988
          Curator_confirmed: WBPerson12884
            WBPerson324
          Date_last_updated: 18 Aug 2011 00:00:00
      Automated_description: Enables procollagen-proline 4-dioxygenase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; embryo development; and embryonic body morphogenesis. Located in endoplasmic reticulum. Expressed in hypodermis; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in myopia. Is an ortholog of human P4HA1 (prolyl 4-hydroxylase subunit alpha 1) and P4HA2 (prolyl 4-hydroxylase subunit alpha 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11830 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8547)
  Molecular_info: Corresponding_CDS: Y47D3B.10
    Corresponding_transcript: Y47D3B.10.1
    Other_sequence (83)
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00056767 Inferred_automatically: RNAi_primary
      WBRNAi00115627 Inferred_automatically: RNAi_primary
      WBRNAi00027622 Inferred_automatically: RNAi_primary
      WBRNAi00026722 Inferred_automatically: RNAi_primary
      WBRNAi00094817 Inferred_automatically: RNAi_primary
      WBRNAi00065822 Inferred_automatically: RNAi_primary
      WBRNAi00094816 Inferred_automatically: RNAi_primary
      WBRNAi00009344 Inferred_automatically: RNAi_primary
      WBRNAi00019394 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1085
      Expr1928
      Expr1931
      Expr12145
      Expr1012505
      Expr1030685
      Expr1160222
      Expr1200375
      Expr2011060
      Expr2029297
    Drives_construct: WBCnstr00008961
      WBCnstr00010073
      WBCnstr00010524
      WBCnstr00020362
      WBCnstr00037095
    Construct_product: WBCnstr00008961
      WBCnstr00008962
      WBCnstr00008963
      WBCnstr00010073
      WBCnstr00037095
    Antibody: WBAntibody00000539
    Microarray_results (22)
    Expression_cluster (232)
    Interaction (111)
    WBProcess: WBbiopr:00000124
  Map_info: Map: III Position: 8.85117 Error: 0.054776
    Well_ordered
    Positive: Inside_rearr: tDp1
        mT1
      Positive_clone: Y47D3B Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point (58)
      Multi_point (145)
      Pos_neg_data (11)
    Landmark_gene
  Reference (127)
  Method: Gene