WormBase Tree Display for Gene: WBGene00001080

WBGene00001080 Evidence: Paper_evidence: WBPaper00006355
  SMap: S_parent: Sequence: Y59A8B
  Identity: Version: 1
    Name: CGC_name: dpy-21 Person_evidence: WBPerson261
      Sequence_name: Y59A8B.1
      Molecular_name: Y59A8B.1a
        Y59A8B.1a.1
        CE26205
        Y59A8B.1b
      Other_name: Y59A8B.c Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y59A8B.1 Accession_evidence: NDB BX284605
      Public_name: dpy-21
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dpy
    Reference_allele: WBVar00143205
    Allele: WBVar00275301
      WBVar00054387
      WBVar00275296
      WBVar00275318
      WBVar00144033
      WBVar02157964
      WBVar02055235
      WBVar01090398
      WBVar01845490
      WBVar01637659
      WBVar01090399
      WBVar01637660
      WBVar02055236
      WBVar01845491
      WBVar01090400
      WBVar00054015
      WBVar02055237
      WBVar01845492
      WBVar02055238
      WBVar01090401
      WBVar01845493
      WBVar01090402
      WBVar01845494
      WBVar01786700
      WBVar02055239
      WBVar01090403
      WBVar01845495
      WBVar01786701
      WBVar02055240
      WBVar02055241
      WBVar00054020
      WBVar01786702
      WBVar01845496
      WBVar01090404
      WBVar01786703
      WBVar01654412
      WBVar01090405
      WBVar01845497
      WBVar01786704
      WBVar01845498
      WBVar01090406
      WBVar01654413
      WBVar01499709
      WBVar01654414
      WBVar01090407
      WBVar01845499
      WBVar01786705
      WBVar01786706
      WBVar01654415
      WBVar01090408
      WBVar01845500
      WBVar00054025
      WBVar01845501
      WBVar01786707
      WBVar01090409
      WBVar01654416
      WBVar02034614
      WBVar01786708
      WBVar01991786
      WBVar02034615
      WBVar01654417
      WBVar01845502
      WBVar01090410
      WBVar01090411
      WBVar01786709
      WBVar01845503
      WBVar02034616
      WBVar01991787
      WBVar01654418
      WBVar02034617
      WBVar00054030
      WBVar01845504
      WBVar01654419
      WBVar01991788
      WBVar01786710
      WBVar01090412
      WBVar01991789
      WBVar02034618
      WBVar01786711
      WBVar01845505
      WBVar02005056
      WBVar01090413
      WBVar01654420
      WBVar01786712
      WBVar01991790
      WBVar01090414
      WBVar01654421
      WBVar01845506
      WBVar02034619
      WBVar02034620
      WBVar01991791
      WBVar01090415
      WBVar01845507
      WBVar01654422
      WBVar01786713
      WBVar01090416
      WBVar01786714
      WBVar00054035
      WBVar01991792
      WBVar01845508
      WBVar01654423
      WBVar02034621
      WBVar01786715
      WBVar01090417
      WBVar01654424
      WBVar02034622
      WBVar01991793
      WBVar01654425
      WBVar01090418
      WBVar01786716
      WBVar01654426
      WBVar01786717
      WBVar01090419
      WBVar00054040
      WBVar01090420
      WBVar01654427
      WBVar01654428
      WBVar01822117
      WBVar01090421
      WBVar01654429
      WBVar01090422
      WBVar00054045
      WBVar01090423
      WBVar01654430
      WBVar01090424
      WBVar01654431
      WBVar01090425
      WBVar01654432
      WBVar01654433
      WBVar01090426
      WBVar00054050
      WBVar01090427
      WBVar01654434
      WBVar01654435
      WBVar01090428
      WBVar01090429
      WBVar01654436
      WBVar01090430
      WBVar01654437
      WBVar01654438
      WBVar01090431
      WBVar00054055
      WBVar01090432
      WBVar01654439
      WBVar01090433
      WBVar01090434
      WBVar00054060
      WBVar01090435
      WBVar01090436
      WBVar02096528
      WBVar01901275
      WBVar01090437
      WBVar02096529
      WBVar02096530
      WBVar01090438
      WBVar00054065
      WBVar01090439
      WBVar02096531
      WBVar01485389
      WBVar01090440
      WBVar01090441
      WBVar02025258
      WBVar01485390
      WBVar01485391
      WBVar02025259
      WBVar01090442
      WBVar02025260
      WBVar01090443
      WBVar00054070
      WBVar01090444
      WBVar02025261
      WBVar02098744
      WBVar01090445
      WBVar02098745
      WBVar01090446
      WBVar00054075
      WBVar01090447
      WBVar01499566
      WBVar01090448
      WBVar01090449
      WBVar01090450
      WBVar00054080
      WBVar01090451
      WBVar00484649
      WBVar01090452
      WBVar00484650
      WBVar00054085
      WBVar00484651
      WBVar01090453
      WBVar01090454
      WBVar00484652
      WBVar01090455
      WBVar00484653
      WBVar01090456
      WBVar00484654
      WBVar01090457
      WBVar00054090
      WBVar00484655
      WBVar01090458
      WBVar00484656
      WBVar00484657
      WBVar01090459
      WBVar01090460
      WBVar00484658
      WBVar02073464
      WBVar00054095
      WBVar01498290
      WBVar00484659
      WBVar01090461
      WBVar00275299
      WBVar01090462
      WBVar02073465
      WBVar00484660
      WBVar01090463
      WBVar00484661
      WBVar00054100
      WBVar00275307
      WBVar00484662
      WBVar02091404
      WBVar01090464
      WBVar00275319
      WBVar01090465
      WBVar00484663
      WBVar00484664
      WBVar01090466
      WBVar00484665
      WBVar01090467
      WBVar00484666
      WBVar01090468
      WBVar01090469
      WBVar00484667
      WBVar00275332
      WBVar01090470
      WBVar00484668
      WBVar00484669
      WBVar01090471
      WBVar01464921
      WBVar01924804
      WBVar02079070
      WBVar01090472
      WBVar01464922
      WBVar00484670
      WBVar01090473
      WBVar00484671
      WBVar01464923
      WBVar00484672
      WBVar01090474
      WBVar01464924
      WBVar02114234
      WBVar00484673
      WBVar01464925
      WBVar01090475
      WBVar01090476
      WBVar01464926
      WBVar00484674
      WBVar01464927
      WBVar00484675
      WBVar01090477
      WBVar01090478
      WBVar00484676
      WBVar01464928
      WBVar01090479
      WBVar01464929
      WBVar02044148
      WBVar02044149
      WBVar01464931
      WBVar01090480
      WBVar01090481
      WBVar02044150
      WBVar02044151
      WBVar01090482
      WBVar01090483
      WBVar02044152
      WBVar01090484
      WBVar02044153
      WBVar02044154
      WBVar01090485
      WBVar01813150
      WBVar02044155
      WBVar01090486
      WBVar01491692
      WBVar01813151
      WBVar02044156
      WBVar01090487
      WBVar01090488
      WBVar01813152
      WBVar01090489
      WBVar01813153
      WBVar01090490
      WBVar01813154
      WBVar01090491
      WBVar01977220
      WBVar01813155
      WBVar01977221
      WBVar01813156
      WBVar01090492
      WBVar02107993
      WBVar01977222
      WBVar02107994
      WBVar01090493
      WBVar01813157
      WBVar01813158
      WBVar01977223
      WBVar01090494
      WBVar01813159
      WBVar01977224
      WBVar01090495
      WBVar01813160
      WBVar01090496
      WBVar01977225
      WBVar02108365
      WBVar01090497
      WBVar02108366
      WBVar01977226
      WBVar01813161
      WBVar01090498
      WBVar01703237
      WBVar01977227
      WBVar01090499
      WBVar01090500
      WBVar01090501
      WBVar01090502
      WBVar01090503
      WBVar01090504
      WBVar01090505
      WBVar01090506
      WBVar01090507
      WBVar01693088
      WBVar00596213
      WBVar00596214
      WBVar02071268
      WBVar00596217
      WBVar00596221
      WBVar02071269
      WBVar01689776
      WBVar00596224
      WBVar01499446
      WBVar02039002
      WBVar01749227
      WBVar01749228
      WBVar01749229
      WBVar01749230
      WBVar01749231
      WBVar01749232
      WBVar02068868
      WBVar01749233
      WBVar01749234
      WBVar01749235
      WBVar01749236
      WBVar01749237
      WBVar01596407
      WBVar01998468
      WBVar01596408
      WBVar01998469
      WBVar01596409
      WBVar01998470
      WBVar01596410
      WBVar01998471
      WBVar01998472
      WBVar01596411
      WBVar01998473
      WBVar01596412
      WBVar02095155
      WBVar01998474
      WBVar01596413
      WBVar01998475
      WBVar02095156
      WBVar01498549
      WBVar01596414
      WBVar02095157
      WBVar01596415
      WBVar00315864
      WBVar01998476
      WBVar01998477
      WBVar01782005
      WBVar01998478
      WBVar01998479
      WBVar00143205
      WBVar01782006
      WBVar01782007
      WBVar01782008
      WBVar01782009
      WBVar01782010
      WBVar01782011
      WBVar01499299
      WBVar00143229
      WBVar02138097
      WBVar02138098
      WBVar00277958
      WBVar02138099
      WBVar02032642
      WBVar02138100
      WBVar02032643
      WBVar02032644
      WBVar02032645
      WBVar01090386
      WBVar01090387
      WBVar01637649
      WBVar01474474
      WBVar01090388
      WBVar01474475
      WBVar01897176
      WBVar01637650
      WBVar01090389
      WBVar01474476
      WBVar01637651
      WBVar01090390
      WBVar01498957
      WBVar01090391
      WBVar01637652
      WBVar01637653
      WBVar01090392
      WBVar01090393
      WBVar01637654
      WBVar01637655
      WBVar01090394
      WBVar01090395
      WBVar01637656
      WBVar01845487
      WBVar00054010
      WBVar02055233
      WBVar01637657
      WBVar01090396
      WBVar01845488
      WBVar01090397
      WBVar01845489
      WBVar02055234
      WBVar01637658
    Legacy_information: e428 : weak dumpy (XX) non-dumpy (XO); lethal to 2A;3X. ES3 (adult) ES1 (larvae). ME3. NA3 (e459 (resembles e428) ct16 (very weak dumpy)).
      See also e428, e459, e1483
      [C.elegansII] e428 : weak dumpy (XX); non-dumpy (XO); lethal to 2A;3X. ES3 (adult) ES1 (larvae).Some X chromosome transcript levels elevated,in both XX and XO. ME3. OA2: e459 (resembles e428), ct16 (very weak phenotype). [Hodgkin 1983b; Meyer and Casson 1986; TY]
    Strain (20)
    RNASeq_FPKM (74)
    GO_annotation (12)
    Contained_in_operon: CEOP5552
    Ortholog (36)
    Structured_description: Concise_description: dpy-21 encodes a novel, conserved protein with a proline-rich N terminus; dpy-21 affects RNA levels of X-linked dosage-compensated genes, body length in hermaphrodites, and fertility and male tail development in males; DPY-21 interacts in vivo with DPY-27 and SDC-3, members of the dosage compensation complex, and like members of the dosage compensation complex, is diffusely localized in nuclei of XX embryos containing <40 cells, but then specifically localizes to X chromosomes of XX embryos with >40 cells, remaining on the X throughout development; in XO embryos, DPY-21 is dispersed throughout the nucleus in multiple foci that are not coincident with the X chromosome; in hermaphrodites, localization of DPY-21 to the X chromosome requires activity of SDC-2, SDC-3, DPY-26, DPY-27, and DPY-28; DPY-21 is not, however, required reciprocally for the stability or localization of these other dosage compensation proteins; in addition, unlike SDC-3 and other members of the dosage compensation complex, DPY-21 is not recruited to the autosomal her-1 regulatory region, suggesting that DPY-21 is not part of the gene-specific complex that represses her-1 expression in hermaphrodites. Paper_evidence: WBPaper00000665
            WBPaper00000941
            WBPaper00001003
            WBPaper00006355
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 17 Jul 2006 00:00:00
      Automated_description: Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y59A8B.1a
    Corresponding_CDS_history: Y59A8B.1:wp139
    Corresponding_transcript: Y59A8B.1b
      Y59A8B.1a.1
    Other_sequence (17)
    Associated_feature: WBsf653522
      WBsf982072
      WBsf1002778
      WBsf1002779
      WBsf014601
  Experimental_info: RNAi_result: WBRNAi00087176 Inferred_automatically: RNAi_primary
      WBRNAi00037624 Inferred_automatically: RNAi_primary
      WBRNAi00087213 Inferred_automatically: RNAi_primary
      WBRNAi00098753 Inferred_automatically: RNAi_primary
      WBRNAi00086943 Inferred_automatically: RNAi_primary
      WBRNAi00086947 Inferred_automatically: RNAi_primary
      WBRNAi00117567 Inferred_automatically: RNAi_primary
      WBRNAi00086946 Inferred_automatically: RNAi_primary
      WBRNAi00057742 Inferred_automatically: RNAi_primary
      WBRNAi00086944 Inferred_automatically: RNAi_primary
      WBRNAi00116018 Inferred_automatically: RNAi_primary
      WBRNAi00098754 Inferred_automatically: RNAi_primary
      WBRNAi00086945 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2896
      Expr13514
      Expr1027959
      Expr1030687
      Expr1161165
      Expr2011064
      Expr2029301
    Regulate_expr_cluster: WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050801:DPY-21_dauer_regulome
    Antibody: WBAntibody00000707
      WBAntibody00000708
    Microarray_results (20)
    Expression_cluster (115)
    Interaction (71)
    WBProcess: WBbiopr:00000056
  Map_info: Map: V Position: 13.3323 Error: 0.006986
    Well_ordered
    Positive: Inside_rearr: ozDf1
      Positive_clone: Y59A8B Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: ozDf2
    Mapping_data: 2_point (14)
      Multi_point (24)
      Pos_neg_data: 4305
        4291
        4292
        4293
        8970
        8983
    Landmark_gene
  Reference (124)
  Method: Gene