dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression.
Predicted to enable transcription coactivator activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of vulval development. Located in nucleus. Expressed in several structures, including hypodermal cell; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); major depressive disorder; and phobic disorder. Is an ortholog of human MED12L (mediator complex subunit 12L).