WormBase Tree Display for Gene: WBGene00001161

WBGene00001161 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y102A5C
  Identity: Version: 1
    Name: CGC_name: efl-1 Person_evidence: WBPerson268
      Sequence_name: Y102A5C.18
      Molecular_name: Y102A5C.18
        Y102A5C.18.1
        CE20390
      Other_name: mex-2
        CELE_Y102A5C.18 Accession_evidence: NDB BX284605
      Public_name: efl-1
    DB_info: Database: AceView gene 5R440
        WormQTL gene WBGene00001161
        WormFlux gene WBGene00001161
        NDB locus_tag CELE_Y102A5C.18
        Panther gene CAEEL|WormBase=WBGene00001161|UniProtKB=G5EF11
          family PTHR12081
        NCBI gene 180133
        RefSeq protein NM_074888.7
        TrEMBL UniProtAcc G5EF11
        UniProt_GCRP UniProtAcc G5EF11
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: efl
    Allele: WBVar00242722 Inferred_automatically: From strain object: JJ1549
      WBVar00278506
      WBVar02137937
      WBVar02122255
      WBVar02124833
      WBVar01976729
      WBVar01976730
      WBVar02011589
      WBVar01976731
      WBVar01976732
      WBVar01976734
      WBVar01499524
      WBVar01652757
      WBVar01976735
      WBVar01652758
      WBVar01499525
      WBVar02043892
      WBVar02043893
      WBVar01652759
      WBVar01652760
      WBVar02043894
      WBVar01652761
      WBVar02043895
      WBVar00305814
      WBVar01652762
      WBVar02043896
      WBVar02116011
      WBVar02043897
      WBVar01652763
      WBVar02043898
      WBVar01652764
      WBVar02043899
      WBVar01652765
      WBVar01652766
      WBVar02052083
      WBVar02052084
      WBVar02052085
      WBVar01464407
      WBVar02052086
      WBVar01464408
      WBVar00302287
      WBVar02112708
      WBVar01464409
      WBVar01464410
      WBVar00302288
      WBVar01464411
      WBVar01464412
      WBVar00482417
      WBVar00482418
      WBVar00482419
      WBVar00482420
      WBVar00482421
      WBVar02124497
      WBVar00482422
      WBVar00482423
      WBVar00482424
      WBVar01635855
      WBVar00482425
      WBVar01635856
      WBVar00482426
      WBVar01635857
      WBVar00482427
      WBVar01635858
      WBVar00482428
      WBVar01635859
      WBVar00482429
      WBVar00482430
      WBVar00482431
      WBVar00482432
      WBVar02096356
      WBVar01843701
      WBVar01843702
      WBVar01843703
      WBVar01843704
      WBVar01843705
      WBVar02122863
      WBVar01843706
      WBVar01843707
      WBVar01843708
      WBVar01843709
      WBVar01748064
      WBVar01843710
      WBVar01809995
      WBVar00594731
      WBVar02094896
      WBVar01809996
      WBVar01748065
      WBVar00594733
      WBVar01843711
      WBVar01809997
      WBVar00594734
      WBVar01748066
      WBVar01498290
      WBVar02122686
      WBVar01748067
      WBVar01809998
      WBVar01809999
      WBVar01748068
      WBVar01924796
      WBVar01810000
      WBVar01748069
      WBVar01894450
      WBVar01748070
      WBVar01810001
      WBVar00043865
      WBVar01748071
      WBVar00090685
      WBVar01810002
      WBVar01748072
      WBVar01810003
      WBVar01748073
      WBVar01810004
      WBVar01748074
      WBVar02122326
      WBVar00043870
      WBVar01810005
      WBVar01748075
      WBVar01810006
      WBVar01810007
      WBVar01748076
      WBVar00043875
      WBVar01810008
      WBVar01810009
      WBVar01810010
      WBVar00043880
      WBVar01410804
      WBVar01810011
      WBVar02124908
      WBVar01410805
      WBVar01810012
      WBVar00043885
      WBVar01410806
      WBVar01810013
      WBVar01810014
      WBVar01410807
      WBVar01810015
      WBVar00043890
      WBVar01810016
      WBVar01495549
      WBVar01810017
      WBVar00043895
      WBVar00043900
      WBVar00043905
      WBVar02121796
      WBVar00043910
      WBVar01594347
      WBVar01485259
      WBVar01594348
      WBVar02071252
      WBVar00043915
      WBVar01594349
      WBVar01485260
      WBVar02071253
      WBVar01485261
      WBVar01594350
      WBVar01594351
      WBVar01485262
      WBVar00043920
      WBVar01485263
      WBVar01594352
      WBVar01485264
      WBVar01594353
      WBVar01485265
      WBVar01594354
      WBVar00043925
      WBVar01594355
      WBVar00090739
      WBVar01594356
      WBVar01594357
      WBVar00043930
      WBVar01594358
      WBVar01500175
      WBVar01594359
      WBVar01594360
      WBVar00043935
      WBVar01594361
      WBVar02114083
      WBVar00043940
      WBVar01499446
      WBVar01899691
      WBVar01498710
      WBVar01899692
      WBVar00043945
      WBVar01899693
      WBVar02091271
      WBVar00043950
      WBVar02091272
      WBVar02091273
      WBVar02091274
      WBVar02121639
      WBVar00043955
      WBVar00043960
      WBVar02117963
      WBVar02110787
      WBVar02110788
      WBVar00043965
      WBVar02123303
      WBVar00043970
      WBVar00043975
      WBVar00043980
      WBVar01991539
      WBVar01083722
      WBVar02010890
      WBVar01083723
      WBVar01834658
      WBVar00043985
      WBVar01834659
      WBVar02055005
      WBVar01083724
      WBVar01498549
      WBVar01083725
      WBVar02055006
      WBVar00043990
      WBVar01834660
      WBVar02025171
      WBVar01083726
      WBVar01834661
      WBVar02055007
      WBVar02025172
      WBVar01083727
      WBVar02105095
      WBVar02055008
      WBVar02025173
      WBVar01083728
      WBVar02055009
      WBVar00043995
      WBVar01083729
      WBVar02055010
      WBVar02025174
      WBVar01083730
      WBVar02025175
      WBVar02055011
      WBVar02121296
      WBVar02055012
      WBVar01083731
      WBVar02025176
      WBVar00044000
      WBVar02055013
      WBVar01083732
      WBVar02025177
      WBVar01083733
      WBVar02025178
      WBVar02055014
      WBVar02124059
      WBVar01083734
      WBVar02025179
      WBVar00044005
      WBVar01398515
      WBVar01398516
      WBVar01083735
      WBVar01083736
      WBVar01398517
      WBVar01499299
      WBVar01398518
      WBVar02124430
      WBVar00044010
      WBVar02123142
      WBVar01083737
      WBVar01398519
      WBVar01083738
      WBVar01083739
      WBVar01083740
      WBVar00044015
      WBVar01083741
      WBVar00531856
      WBVar01083742
      WBVar00044020
      WBVar01083743
      WBVar01083744
      WBVar01083745
      WBVar01083746
      WBVar00044025
      WBVar02107876
      WBVar01083747
      WBVar01083748
      WBVar00044030
      WBVar01083749
      WBVar02124626
      WBVar02123708
      WBVar00044035
      WBVar01275811
      WBVar00044040
      WBVar01275813
      WBVar01275818
      WBVar00044045
      WBVar00044050
      WBVar02124270
      WBVar00044055
      WBVar00044060
      WBVar01779652
      WBVar00044065
    Legacy_information: [C.elegansII] Mutation maternal effect lethal, leading to production of excess muscle cells, like Mex-1. [JJ]
    Strain: WBStrain00027369
      WBStrain00036784
      WBStrain00022494
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (37)
    Paralog: WBGene00001162 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00009899 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: efl-1 encodes a homolog of mammalian E2F that is required for embryonic asymmetry and that functions as a transcriptional repressor; during vulval development, efl-1, a class B synMuv gene, acts with class B synMuv genes dpl-1 and lin-35/Rb to antagonize receptor tyrosine kinase and Ras-mediated signaling; EFL-1 also negatively regulates the G1 to S phase cell cycle transition. Paper_evidence: WBPaper00004589
            WBPaper00004634
            WBPaper00004635
            WBPaper00005298
            WBPaper00005708
          Curator_confirmed: WBPerson1843
          Date_last_updated: 10 Nov 2005 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic digestive tract morphogenesis; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Expressed in gonad. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate carcinoma. Is an ortholog of human E2F4 (E2F transcription factor 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10286 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3119)
      DOID:3883 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3118)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3119)
  Molecular_info: Corresponding_CDS: Y102A5C.18
    Corresponding_transcript: Y102A5C.18.1
    Other_sequence (41)
    Associated_feature: WBsf653499
      WBsf669813
      WBsf978922
      WBsf982066
      WBsf1002576
      WBsf1002577
      WBsf1021218
      WBsf1021219
    Gene_product_binds (13485)
    Transcription_factor: WBTranscriptionFactor000455
  Experimental_info: RNAi_result (52)
    Expr_pattern: Expr4031
      Expr1016766
      Expr1030739
      Expr1158669
      Expr2011189
      Expr2029425
    Drives_construct: WBCnstr00017291
    Construct_product: WBCnstr00017289
      WBCnstr00017291
      WBCnstr00017292
    Regulate_expr_cluster: WBPaper00027758:Group_I
      WBPaper00027758:Group_II
      WBPaper00027758:Group_III
      WBPaper00027758:Regulated_genes_not_in_group
      WBPaper00062056:efl-1(se1)_downregulated
      WBPaper00062056:efl-1(se1)_upregulated
    Antibody: WBAntibody00000356
    Microarray_results (20)
    Expression_cluster (141)
    Interaction (171)
    Product_binds_matrix (12)
  Map_info: Map: V Position: 11.3775 Error: 0.003321
    Positive: Positive_clone: Y54E10BL
        Y102A5C Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4125
        5410
  Reference (76)
  Picture: WBPicture0000013091
  Remark: [Ceol C, Horvitz HR] efl-1 Y102A5C.18
    WE had this mis-linked to Y54E10BL.6 instead of the real gene mek-2. [sdm 010320]
    Sequence connection from [?]
    Y54E10BL.6 removed again. 09/2001 sdm
  Method: Gene