WormBase Tree Display for Gene: WBGene00001864

WBGene00001864 SMap: S_parent: Sequence: D1086
  Identity: Version: 2
    Name: CGC_name: him-5 Person_evidence: WBPerson261
      Sequence_name: D1086.4
      Molecular_name: D1086.4a
        D1086.4a.1
        CE09062
        D1086.4b
        CE45310
        D1086.4b.1
      Other_name: CELE_D1086.4 Accession_evidence: NDB BX284605
      Public_name: him-5
    DB_info: Database: WormQTL gene WBGene00001864
        WormFlux gene WBGene00001864
        NDB locus_tag CELE_D1086.4
        NCBI gene 183932
        RefSeq protein NM_001269627.3
            NM_001269626.2
        TrEMBL UniProtAcc O17724
            E1B6V2
        UniProt_GCRP UniProtAcc O17724
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 22 Aug 2008 17:09:12 WBPerson2970 Event: Acquires_merge: WBGene00008391
              Name_change: Sequence_name: D1086.4
      Acquires_merge: WBGene00008391
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: him
    Reference_allele: WBVar00144023
    Allele (43)
    Legacy_information: e1467ts : at 20x self-progeny 16% XO male 11% ova are nullo-X as a result of reductional meiotic nondisjunction; X chromosome recombination specifically reduced 50%. ES3 (progeny). ME3. NA2 (e1490 (stronger allele : 33% Him at 20x)).
      See also e1467, e1490
      [C.elegansII] e1467ts : at 20C self-progeny 16% XO male, 3% 3X herm, 11% ova are nullo-X as a result of reductional meiotic nondisjunction; X chromosome recombination specifically reduced 50% or more, except at left end (increased); additional sterility not due to autosomal nondisjunction ( brood reduced 64% at 25C); some embryonic lethality. ES3 (progeny). ME3. OA4: e1490 (stronger allele : 33% Him at 20C)). Cloned: cosmid rescue K02A12. [Hodgkin et al. 1979; Broverman and Meneely 1994; FH]
    Strain (490)
    RNASeq_FPKM (74)
    GO_annotation: 00008104
      00030516
      00030517
      00030518
    Ortholog: chrV_pilon.g16429 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: him-5 was identified in screens for genes that when mutated resulted in an increased frequency of X chromosome nondisjunction and thus, an increased frequency of genotypically XO males in self-fertile populations; him-5 functions in X chromosome dynamics by regulating the number and distribution of X chromosome pairing events. Paper_evidence: WBPaper00000179
            WBPaper00001852
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Oct 2010 00:00:00
      Automated_description: Involved in meiotic DNA double-strand break formation involved in reciprocal meiotic recombination and meiotic chromosome segregation. Located in condensed chromosome. Expressed in gonad. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: D1086.4a
      D1086.4b
    Corresponding_transcript: D1086.4a.1
      D1086.4b.1
    Associated_feature: WBsf647510
      WBsf232867
      WBsf232868
      WBsf232869
  Experimental_info: RNAi_result: WBRNAi00030368 Inferred_automatically: RNAi_primary
      WBRNAi00111474 Inferred_automatically: RNAi_primary
      WBRNAi00012552 Inferred_automatically: RNAi_primary
      WBRNAi00061770 Inferred_automatically: RNAi_primary
      WBRNAi00043422 Inferred_automatically: RNAi_primary
      WBRNAi00111473 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9917
      Expr1023729
      Expr1031097
      Expr1147415
      Expr2012430
      Expr2030666
    Drives_construct: WBCnstr00036641
      WBCnstr00038151
    Construct_product: WBCnstr00036641
      WBCnstr00038150
      WBCnstr00038151
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045861:wdr-5(ok1417)_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_upregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057083:daf-2(e1370)rsks-1(ok1255)_post-transcriptional_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059378:lmn-1(Y59C)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:Germline
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_41
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00033101:spr-5_regulated
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037611:GLD-2-associated
      WBPaper00037611:RNP-8-associated
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (68)
  Map_info: Map: V Position: 6.09216 Error: 0.018285
    Well_ordered
    Positive: Positive_clone: D1086 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 308
        6177
      Multi_point (33)
      Pos_neg_data: 1761
        4301
        6866
        7401
    Landmark_gene
  Reference: WBPaper00000179
    WBPaper00000447
    WBPaper00000498
    WBPaper00000536
    WBPaper00000565
    WBPaper00000608
    WBPaper00000634
    WBPaper00000655
    WBPaper00000656
    WBPaper00000665
    WBPaper00000676
    WBPaper00000739
    WBPaper00000879
    WBPaper00000902
    WBPaper00000913
    WBPaper00000983
    WBPaper00001005
    WBPaper00001028
    WBPaper00001057
    WBPaper00001079
    WBPaper00001227
    WBPaper00001404
    WBPaper00001416
    WBPaper00001433
    WBPaper00001526
    WBPaper00001558
    WBPaper00001573
    WBPaper00001612
    WBPaper00001638
    WBPaper00001649
    WBPaper00001667
    WBPaper00001677
    WBPaper00001691
    WBPaper00001706
    WBPaper00001709
    WBPaper00001720
    WBPaper00001738
    WBPaper00001745
    WBPaper00001748
    WBPaper00001768
    WBPaper00001852
    WBPaper00001869
    WBPaper00002206
    WBPaper00002226
    WBPaper00002374
    WBPaper00002459
    WBPaper00002497
    WBPaper00002534
    WBPaper00002627
    WBPaper00002802
    WBPaper00002827
    WBPaper00003401
    WBPaper00003403
    WBPaper00003454
    WBPaper00003719
    WBPaper00003910
    WBPaper00003923
    WBPaper00003924
    WBPaper00003927
    WBPaper00004213
    WBPaper00004396
    WBPaper00004435
    WBPaper00004476
    WBPaper00004489
    WBPaper00004883
    WBPaper00005138
    WBPaper00005237
    WBPaper00005567
    WBPaper00005921
    WBPaper00006110
    WBPaper00006389
    WBPaper00006390
    WBPaper00010626
    WBPaper00010692
    WBPaper00010714
    WBPaper00010982
    WBPaper00011094
    WBPaper00011731
    WBPaper00013698
    WBPaper00013858
    WBPaper00013865
    WBPaper00013953
    WBPaper00014013
    WBPaper00014081
    WBPaper00014084
    WBPaper00014182
    WBPaper00014205
    WBPaper00014208
    WBPaper00014210
    WBPaper00014230
    WBPaper00014393
    WBPaper00014443
    WBPaper00014503
    WBPaper00014519
    WBPaper00014708
    WBPaper00014709
    WBPaper00014911
    WBPaper00014922
    WBPaper00014999
    WBPaper00015048
    WBPaper00015229
    WBPaper00015355
    WBPaper00015397
    WBPaper00015590
    WBPaper00015660
    WBPaper00015943
    WBPaper00016028
    WBPaper00016077
    WBPaper00016084
    WBPaper00016131
    WBPaper00016149
    WBPaper00016180
    WBPaper00016216
    WBPaper00016247
    WBPaper00016289
    WBPaper00016311
    WBPaper00016314
    WBPaper00016397
    WBPaper00016421
    WBPaper00016425
    WBPaper00016503
    WBPaper00016513
    WBPaper00016555
    WBPaper00016928
    WBPaper00017039
    WBPaper00017050
    WBPaper00017502
    WBPaper00017507
    WBPaper00017613
    WBPaper00017688
    WBPaper00017745
    WBPaper00017875
    WBPaper00018078
    WBPaper00018097
    WBPaper00018315
    WBPaper00018749
    WBPaper00018766
    WBPaper00019458
    WBPaper00019666
    WBPaper00021083
    WBPaper00021709
    WBPaper00021812
    WBPaper00021818
    WBPaper00021912
    WBPaper00021988
    WBPaper00022124
    WBPaper00022265
    WBPaper00022275
    WBPaper00022362
    WBPaper00022633
    WBPaper00022720
    WBPaper00022894
    WBPaper00023429
    WBPaper00023452
    WBPaper00023825
    WBPaper00024323
    WBPaper00024329
    WBPaper00024428
    WBPaper00025119
    WBPaper00025577
    WBPaper00026418
    WBPaper00026477
    WBPaper00027236
    WBPaper00027716
    WBPaper00027757
    WBPaper00027832
    WBPaper00028104
    WBPaper00029013
    WBPaper00030145
    WBPaper00030672
    WBPaper00030837
    WBPaper00030887
    WBPaper00031432
    WBPaper00031484
    WBPaper00031510
    WBPaper00031689
    WBPaper00031871
    WBPaper00032050
    WBPaper00032266
    WBPaper00034110
    WBPaper00034402
    WBPaper00034408
    WBPaper00037367
    WBPaper00037376
    WBPaper00038542
    WBPaper00038687
    WBPaper00038703
    WBPaper00039045
    WBPaper00041537
    WBPaper00042677
    WBPaper00043275
    WBPaper00043757
    WBPaper00044269
    WBPaper00047290
    WBPaper00047291
    WBPaper00047919
    WBPaper00048558
    WBPaper00048917
    WBPaper00049555
    WBPaper00050180
    WBPaper00052031
    WBPaper00053311
    WBPaper00053312
    WBPaper00053313
    WBPaper00053325
    WBPaper00054685
    WBPaper00055216
    WBPaper00055321
    WBPaper00056598
    WBPaper00056672
    WBPaper00056982
    WBPaper00057798
    WBPaper00059179
    WBPaper00059520
    WBPaper00059578
    WBPaper00059854
    WBPaper00060130
    WBPaper00060545
    WBPaper00061871
    WBPaper00062189
    WBPaper00062457
    WBPaper00062715
    WBPaper00063123
    WBPaper00063882
    WBPaper00063926
    WBPaper00063946
    WBPaper00064233
    WBPaper00064242
    WBPaper00064502
    WBPaper00064660
    WBPaper00064694
    WBPaper00064805
    WBPaper00065100
    WBPaper00065228
    WBPaper00065660
    WBPaper00065847
    WBPaper00065929
    WBPaper00065964
    WBPaper00066196
  Remark: This locus was previously connected to Y54G2A.1 which was a mistake [030212 krb]
  Method: Gene