WormBase Tree Display for Gene: WBGene00001964

WBGene00001964 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C17C3
  Identity: Version: 1
    Name: CGC_name: hlh-25 Person_evidence: WBPerson346
      Sequence_name: C17C3.7
      Molecular_name: C17C3.7
        C17C3.7.1
        CE42919
      Other_name: CELE_C17C3.7 Accession_evidence: NDB BX284602
      Public_name: hlh-25
    DB_info: Database: AceView gene 2F825
        WormQTL gene WBGene00001964
        WormFlux gene WBGene00001964
        NDB locus_tag CELE_C17C3.7
        Panther gene CAEEL|WormBase=WBGene00001964|UniProtKB=Q18054
          family PTHR10985
        NCBI gene 182717
        RefSeq protein NM_062662.3
        SwissProt UniProtAcc Q18054
        TREEFAM TREEFAM_ID TF322171
        UniProt_GCRP UniProtAcc Q18054
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hlh
    Allele (12)
    Strain: WBStrain00036426
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (22)
    Paralog: WBGene00003008 Caenorhabditis elegans From_analysis: Panther
      WBGene00001968 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00001967 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00001966 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001965 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
    Structured_description: Concise_description: hlh-25 encodes a REF-1-like protein with two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-deficient genetic backgrounds; HLH-25 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-25 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage; ectopic HLH-25 can induce body muscle development in skn-1(RNAi);pal-1(RNAi) embryos that would otherwise lack muscle; HLH-25 is required for embryonic viability in mass RNAi assays. Paper_evidence: WBPaper00006395
            WBPaper00025235
          Curator_confirmed: WBPerson567
          Date_last_updated: 18 Apr 2008 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including MSpa; anal depressor muscle; body wall musculature; intestinal cell; and neurons. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C17C3.7
    Corresponding_CDS_history: C17C3.7:wp193
    Corresponding_transcript: C17C3.7.1
    Associated_feature: WBsf978550
    Transcription_factor: WBTranscriptionFactor000072
  Experimental_info: RNAi_result: WBRNAi00010905 Inferred_automatically: RNAi_primary
      WBRNAi00010899 Inferred_automatically: RNAi_primary
      WBRNAi00084010 Inferred_automatically: RNAi_primary
      WBRNAi00040773 Inferred_automatically: RNAi_primary
      WBRNAi00024579 Inferred_automatically: RNAi_primary
      WBRNAi00040785 Inferred_automatically: RNAi_primary
      WBRNAi00027179 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3495
      Expr8067
      Expr12501
      Expr1144824
      Expr2012500
      Expr2030739
    Drives_construct: WBCnstr00005197
      WBCnstr00011427
      WBCnstr00021040
      WBCnstr00021041
      WBCnstr00036556
    Construct_product: WBCnstr00005197
      WBCnstr00021041
      WBCnstr00036556
    Regulate_expr_cluster: WBPaper00048624:hlh-25(ok1710)_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
    Microarray_results (15)
    Expression_cluster (32)
    Interaction (59)
  Map_info: Map: II Position: -1.19086 Error: 0.002255
    Positive: Positive_clone: C17C3 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (10)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene