WormBase Tree Display for Gene: WBGene00001980

WBGene00001980 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: hmr-1 Person_evidence: WBPerson498
      Sequence_name: W02B9.1
      Molecular_name (13)
      Other_name: CELE_W02B9.1 Accession_evidence: NDB BX284601
      Public_name: hmr-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hmr
    Allele (936)
    Strain: WBStrain00033419
      WBStrain00024209
      WBStrain00024233
      WBStrain00034583
      WBStrain00037750
      WBStrain00022481
      WBStrain00022484
    RNASeq_FPKM (74)
    GO_annotation (45)
    Ortholog (43)
    Paralog: WBGene00001475 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017576 Caenorhabditis elegans From_analysis: Panther
      WBGene00022103 Caenorhabditis elegans From_analysis: Panther
      WBGene00014914 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
            WormBase-Compara
    Structured_description: Concise_description: hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic tissue and body morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. Paper_evidence: WBPaper00003046
            WBPaper00005031
            WBPaper00013424
            WBPaper00040399
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 16 Nov 2011 00:00:00
      Automated_description: Enables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction; distal dendrite; and plasma membrane. Part of catenin complex. Expressed in several structures, including germline precursor cell; hypodermis; motor neurons; nerve ring; and neuroblasts. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: W02B9.1a
      W02B9.1b
      W02B9.1d
      W02B9.1e
    Corresponding_CDS_history: W02B9.1a:wp229
      W02B9.1c:wp274
    Corresponding_transcript: W02B9.1a.1
      W02B9.1a.2
      W02B9.1b.1
      W02B9.1d.1
      W02B9.1e.1
    Other_sequence (52)
    Associated_feature (71)
  Experimental_info: RNAi_result (61)
    Expr_pattern (17)
    Drives_construct (11)
    Construct_product: WBCnstr00006080
      WBCnstr00010445
      WBCnstr00014624
      WBCnstr00014629
      WBCnstr00014630
      WBCnstr00014636
      WBCnstr00020940
      WBCnstr00021692
      WBCnstr00021693
      WBCnstr00023099
    Antibody: WBAntibody00000169
      WBAntibody00002173
      WBAntibody00002591
      WBAntibody00002643
      WBAntibody00002693
    Microarray_results (38)
    Expression_cluster (173)
    Interaction: WBInteraction000003379
      WBInteraction000003380
      WBInteraction000009549
      WBInteraction000029065
      WBInteraction000034748
      WBInteraction000036762
      WBInteraction000038248
      WBInteraction000041678
      WBInteraction000041806
      WBInteraction000047009
      WBInteraction000048415
      WBInteraction000048515
      WBInteraction000126366
      WBInteraction000126367
      WBInteraction000126540
      WBInteraction000127439
      WBInteraction000143161
      WBInteraction000143167
      WBInteraction000143176
      WBInteraction000151157
      WBInteraction000177206
      WBInteraction000177209
      WBInteraction000196886
      WBInteraction000202997
      WBInteraction000203139
      WBInteraction000205932
      WBInteraction000221469
      WBInteraction000232998
      WBInteraction000238145
      WBInteraction000238809
      WBInteraction000248260
      WBInteraction000262849
      WBInteraction000264401
      WBInteraction000285898
      WBInteraction000286636
      WBInteraction000289573
      WBInteraction000291465
      WBInteraction000299975
      WBInteraction000302507
      WBInteraction000305601
      WBInteraction000321649
      WBInteraction000330649
      WBInteraction000334458
      WBInteraction000342039
      WBInteraction000349782
      WBInteraction000360134
      WBInteraction000360940
      WBInteraction000370348
      WBInteraction000373702
      WBInteraction000387045
      WBInteraction000389171
      WBInteraction000394595
      WBInteraction000408086
      WBInteraction000411974
      WBInteraction000415704
      WBInteraction000418259
      WBInteraction000425022
      WBInteraction000427312
      WBInteraction000427380
      WBInteraction000427618
      WBInteraction000427679
      WBInteraction000432984
      WBInteraction000435201
      WBInteraction000435593
      WBInteraction000443965
      WBInteraction000445416
      WBInteraction000446521
      WBInteraction000448062
      WBInteraction000451197
      WBInteraction000452092
      WBInteraction000460194
      WBInteraction000501918
      WBInteraction000501920
      WBInteraction000502827
      WBInteraction000503751
      WBInteraction000504878
      WBInteraction000520464
      WBInteraction000522317
      WBInteraction000522449
      WBInteraction000522450
      WBInteraction000523970
      WBInteraction000525228
      WBInteraction000532890
      WBInteraction000532893
      WBInteraction000532894
      WBInteraction000534848
      WBInteraction000539752
      WBInteraction000541756
      WBInteraction000542712
      WBInteraction000543779
      WBInteraction000543780
      WBInteraction000543781
      WBInteraction000543782
      WBInteraction000543783
      WBInteraction000553276
      WBInteraction000555506
      WBInteraction000555507
      WBInteraction000555508
      WBInteraction000555509
      WBInteraction000555510
      WBInteraction000555511
      WBInteraction000555993
      WBInteraction000555994
      WBInteraction000556524
      WBInteraction000557092
      WBInteraction000558159
      WBInteraction000558160
      WBInteraction000560326
      WBInteraction000562607
    WBProcess: WBbiopr:00000073
  Map_info: Map: I Position: 6.60962 Error: 0.05706
    Positive: Positive_clone: W02B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4410
        4851
        4818
        5481
    Pseudo_map_position
  Reference (111)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene