WormBase Tree Display for Gene: WBGene00002210
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| WBGene00002210 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F58H12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | kin-29 | |||||||
| Sequence_name | F58H12.1 | ||||||||
| Molecular_name | F58H12.1 | ||||||||
| F58H12.1.1 | |||||||||
| CE28479 | |||||||||
| Other_name | sma-11 | ||||||||
| sns-8 | |||||||||
| CELE_F58H12.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | kin-29 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kin | ||||||||
| Allele (158) | |||||||||
| Possibly_affected_by | WBVar02152947 | ||||||||
| Strain | WBStrain00031139 | ||||||||
| WBStrain00031130 | |||||||||
| WBStrain00031135 | |||||||||
| WBStrain00031136 | |||||||||
| WBStrain00031137 | |||||||||
| WBStrain00035855 | |||||||||
| WBStrain00035898 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (49) | |||||||||
| Ortholog (26) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the dauer pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock, KIN-29-GFP translocates to the nucleus. | Paper_evidence | WBPaper00005098 | |||||
| WBPaper00005858 | |||||||||
| WBPaper00010223 | |||||||||
| WBPaper00019247 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 03 Jan 2013 00:00:00 | ||||||||
| Automated_description | Enables histone deacetylase inhibitor activity and protein serine/threonine kinase activity. Involved in several processes, including dauer entry; positive regulation of growth rate; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Expressed in body wall musculature; hypodermis; intestine; nervous system; and non-striated muscle. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F58H12.1 | |||||||
| Corresponding_transcript | F58H12.1.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00016028 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00049074 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098420 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001523 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1773 | ||||||||
| Expr8628 | |||||||||
| Expr14895 | |||||||||
| Expr14935 | |||||||||
| Expr15043 | |||||||||
| Expr1014516 | |||||||||
| Expr1031292 | |||||||||
| Expr1152815 | |||||||||
| Expr2012937 | |||||||||
| Expr2031169 | |||||||||
| Drives_construct | WBCnstr00000340 | ||||||||
| WBCnstr00001664 | |||||||||
| WBCnstr00001676 | |||||||||
| WBCnstr00010432 | |||||||||
| WBCnstr00013407 | |||||||||
| WBCnstr00036385 | |||||||||
| Construct_product | WBCnstr00001664 | ||||||||
| WBCnstr00010432 | |||||||||
| WBCnstr00013407 | |||||||||
| WBCnstr00036385 | |||||||||
| WBCnstr00041592 | |||||||||
| WBCnstr00041883 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction (45) | |||||||||
| Map_info | Map | X | Position | -12.6998 | Error | 0.039611 | |||
| Positive | Positive_clone | F58H12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4095 | |||||||
| 4942 | |||||||||
| Pos_neg_data | 10731 | ||||||||
| Reference (44) | |||||||||
| Remark | This gene (kin-29) was formerly known as sma-11 which in turn was formerly known as sns-8. [krb 030739] | ||||||||
| Method | Gene |
