WormBase Tree Display for Gene: WBGene00003319
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| WBGene00003319 | Evidence | Paper_evidence | WBPaper00005879 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPaper00005825 | |||||||||
| SMap | S_parent | Sequence | C29E6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mir-124 | Person_evidence | WBPerson18 | |||||
| Sequence_name | C29E6.7 | ||||||||
| Molecular_name | C29E6.7 | ||||||||
| C29E6.7a | |||||||||
| C29E6.7b | |||||||||
| Other_name | cel-mir-124 | Remark | miRBase V21 import | ||||||
| MirGeneDB 2.1 import | |||||||||
| CELE_C29E6.7 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | mir-124 | ||||||||
| DB_info | Database | miRBase | acc | MI0000302 | |||||
| SignaLink | mirna | cel-mir-124 | |||||||
| MirGeneDB | cel | Cel-Mir-124 | |||||||
| OMIM | disease | 277700 | |||||||
| gene | 609327 | ||||||||
| NDB | locus_tag | CELE_C29E6.7 | |||||||
| NCBI | gene | 3565990 | |||||||
| RefSeq | protein | NR_002382.2 | |||||||
| RNAcentral | URSid | URS000016C218 | |||||||
| URS0000324A65 | |||||||||
| URS000040D400 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001265 | |||||||
| Gene_class | mir | ||||||||
| Allele | WBVar01500079 | ||||||||
| WBVar01498996 | |||||||||
| WBVar01499925 | |||||||||
| WBVar00090811 | |||||||||
| WBVar01500245 | |||||||||
| Strain | WBStrain00027428 | ||||||||
| WBStrain00034639 | |||||||||
| WBStrain00040276 | |||||||||
| In_cluster | MIR-124 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| Ortholog | HGNC:31502 | Homo sapiens | Accession_evidence | miRBase | MIPF0000021 | ||||
| HGNC:31503 | Homo sapiens | Accession_evidence | miRBase | MIPF0000021 | |||||
| HGNC:31504 | Homo sapiens | Accession_evidence | miRBase | MIPF0000021 | |||||
| Structured_description | Concise_description | mir-124 encodes a highly conserved microRNA, a small non-protein coding RNA; based on RNA sequence, the miR-124 family of microRNAs includes C. elegans miR-228 and human miR-124A1, miR-124A2, miR-124A3 and miR-183; miR-124 is mostly expressed in the nervous system,; in C. elegans it is expressed in a subset of sensory neurons, where it may regulate the expression of target genes; mir-124 also plays a role in aging, as mutants show reduced lifespan, increased reactive oxygen species (ROS) and reduction in ATP levels. | Paper_evidence | WBPaper00005825 | |||||
| WBPaper00005879 | |||||||||
| WBPaper00035973 | |||||||||
| WBPaper00041652 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Dec 2013 00:00:00 | ||||||||
| Automated_description | Expressed in nervous system and tail. Used to study Werner syndrome. Is an ortholog of human MIR124-1 (microRNA 124-1); MIR124-2 (microRNA 124-2); and MIR124-3 (microRNA 124-3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:5688 | Homo sapiens | Paper_evidence | WBPaper00041652 | ||||
| Accession_evidence | OMIM | 277700 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Oct 2018 00:00:00 | ||||||||
| Disease_relevance | mir-124 is a highly conserved microRNA (miRNA); C. elegans has been used as a model system to study the exact function and importance of this miRNA in accelerated aging, which occurs in diseases like Werner syndrome; mutations in the human WRN gene (also called RECQL2) have been implicated in Werner syndrome; studies in elegans and mice indicate that in wrn-1/WRN mutant animals, the microRNA miR-124 is significantly reduced; mir-124 mutants in C. elegans show reduced lifespan, increased reactive oxygen species (ROS) and reduction in ATP levels; double mutants of mir-124 and wrn-1 showed further reduction in lifespan and ATP levels, and increased ROS generation. | Homo sapiens | Paper_evidence | WBPaper00035973 | |||||
| WBPaper00041652 | |||||||||
| Accession_evidence | OMIM | 277700 | |||||||
| 609327 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Dec 2013 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000257 | ||||||||
| WBDOannot00000623 | |||||||||
| Molecular_info | Corresponding_transcript | C29E6.7 | |||||||
| C29E6.7a | |||||||||
| C29E6.7b | |||||||||
| Experimental_info | Expr_pattern | Expr2503 | |||||||
| Expr8945 | |||||||||
| Expr10944 | |||||||||
| Expr12853 | |||||||||
| Expr13534 | |||||||||
| Drives_construct | WBCnstr00005987 | ||||||||
| WBCnstr00016043 | |||||||||
| WBCnstr00022904 | |||||||||
| Expression_cluster (24) | |||||||||
| Interaction (48) | |||||||||
| Map_info | Map | IV | Position | 5.35462 | Error | 0.004076 | |||
| Positive | Positive_clone | C29E6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5253 | |||||||
| 5308 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
