WormBase Tree Display for Gene: WBGene00003885
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WBGene00003885 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y41G9A | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | osm-5 | Person_evidence | WBPerson242 | |||||
Sequence_name | Y41G9A.1 | ||||||||
Molecular_name | Y41G9A.1 | ||||||||
Y41G9A.1.1 | |||||||||
CE28361 | |||||||||
Other_name | CELE_Y41G9A.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | osm-5 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | osm | ||||||||
Reference_allele | WBVar00095130 | ||||||||
Allele (145) | |||||||||
Legacy_information | p813 : same phenotypes as osm-1(p808) also males suicidal poor mating. ES1 ME1. NA1. | ||||||||
See also p813 | |||||||||
[C.elegansII] p813 : fails to avoid 4M fructose or 4M NaCl; poor chemotaxis to NaCl; normal thermotaxis; fails to take up FITC; Daf-d; severely shortened axonemes, ectopic assembly of ciliary structures and microtubules in many sensory neurons; also males suicidal, poor mating. ES1 ME1. OA>6: m184, mn397 [Perkins et al. 1986; Starich et al. 1995; SP; DR] | |||||||||
[Haycraft CJ] osm-5 cloned, is Y41G9A.1 encoding homolog of murine cystic kidney disease gene Tg737. p813 is codon473stop, mn397 is G229E, sa130 is mutated at exon 3 5' donor. | |||||||||
Strain | WBStrain00030797 | ||||||||
WBStrain00035629 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (23) | |||||||||
Ortholog (36) | |||||||||
Paralog | WBGene00000244 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
WBGene00003858 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00017983 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00018175 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00021444 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00021613 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00043992 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | osm-5 encodes the ortholog of the murine polycystic kidney disease gene Tg737 (which encodes the protein Polaris) and human IFT88; osm-5 is required for the proper morphology of the cilia of chemosensory neurons and is involved in intraflagellar transport; the abnormalities in cilia structure in osm-5 mutants lead to defects in several processes like osmotic avoidance, chemotaxis, dauer formation, male mating and life span; osm-5 is expressed in ciliated sensory neurons and localizes to the transition zones of the amphids, phasmids, labials and rays of the male tail; osm-5 expression is regulated by the RFX-type transcription factor, DAF-19, that also regulates the expression of other genes involved in cilia formation. | Paper_evidence | WBPaper00004603 | |||||
WBPaper00005109 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jan 2012 00:00:00 | ||||||||
Automated_description | Predicted to enable kinesin binding activity. Involved in several processes, including dauer entry; locomotory exploration behavior; and non-motile cilium assembly. Located in ciliary basal body; neuron projection; and non-motile cilium. Part of intraciliary transport particle B. Expressed in amphid sensillum and neurons. Used to study autosomal dominant polycystic kidney disease. Is an ortholog of human IFT88 (intraflagellar transport 88). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info (2) | |||||||||
Models_disease_in_annotation | WBDOannot00000030 | ||||||||
Models_disease_asserted | WBDOannot00000513 | ||||||||
Molecular_info | Corresponding_CDS | Y41G9A.1 | |||||||
Corresponding_transcript | Y41G9A.1.1 | ||||||||
Other_sequence (25) | |||||||||
Associated_feature (12) | |||||||||
Experimental_info | RNAi_result | WBRNAi00095205 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00056418 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (13) | |||||||||
Drives_construct (12) | |||||||||
Construct_product | WBCnstr00006237 | ||||||||
WBCnstr00008467 | |||||||||
WBCnstr00009069 | |||||||||
WBCnstr00010229 | |||||||||
WBCnstr00013368 | |||||||||
WBCnstr00039933 | |||||||||
Antibody | WBAntibody00000351 | ||||||||
WBAntibody00001248 | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (200) | |||||||||
Interaction (43) | |||||||||
WBProcess | WBbiopr:00000001 | ||||||||
WBbiopr:00000012 | |||||||||
Map_info | Map | X | Position | -12.6622 | Error | 0.00141 | |||
Well_ordered | |||||||||
Positive | Positive_clone | Y41G9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 376 | |||||||
377 | |||||||||
3384 | |||||||||
Multi_point | 1209 | ||||||||
1210 | |||||||||
1211 | |||||||||
1212 | |||||||||
5291 | |||||||||
5597 | |||||||||
Pos_neg_data | 3180 | ||||||||
5450 | |||||||||
Reference (105) | |||||||||
Remark | Sequence connection from [Haycroft CG, Thomas JH] | ||||||||
Data extracted from Haycraft et al (2001) | |||||||||
Method | Gene |