WormBase Tree Display for Gene: WBGene00003885
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| WBGene00003885 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y41G9A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | osm-5 | Person_evidence | WBPerson242 | |||||
| Sequence_name | Y41G9A.1 | ||||||||
| Molecular_name | Y41G9A.1 | ||||||||
| Y41G9A.1.1 | |||||||||
| CE28361 | |||||||||
| Other_name | CELE_Y41G9A.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | osm-5 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | osm | ||||||||
| Reference_allele | WBVar00095130 | ||||||||
| Allele (145) | |||||||||
| Legacy_information | p813 : same phenotypes as osm-1(p808) also males suicidal poor mating. ES1 ME1. NA1. | ||||||||
| See also p813 | |||||||||
| [C.elegansII] p813 : fails to avoid 4M fructose or 4M NaCl; poor chemotaxis to NaCl; normal thermotaxis; fails to take up FITC; Daf-d; severely shortened axonemes, ectopic assembly of ciliary structures and microtubules in many sensory neurons; also males suicidal, poor mating. ES1 ME1. OA>6: m184, mn397 [Perkins et al. 1986; Starich et al. 1995; SP; DR] | |||||||||
| [Haycraft CJ] osm-5 cloned, is Y41G9A.1 encoding homolog of murine cystic kidney disease gene Tg737. p813 is codon473stop, mn397 is G229E, sa130 is mutated at exon 3 5' donor. | |||||||||
| Strain | WBStrain00030797 | ||||||||
| WBStrain00035629 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00000244 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00003858 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017983 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018175 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021444 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021613 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00043992 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description (2) | |||||||||
| Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence | WBPaper00004603 | ||||
| WBPaper00004715 | |||||||||
| Accession_evidence | OMIM | 173900 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Apr 2018 00:00:00 | ||||||||
| Disease_relevance | Studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; osm-5 is orthologous to the murine polycystic kidney disease gene Tg737, which encodes the protein Polaris and human IFT88; both polaris and OSM-5 have the tetratricopeptide repeat (TPT), a motif that mediates protein-protein interactions; the association of pathologies in mice mutant for Tg737 with ciliary defects in the kidney cells and studies in elegans that demonstrate that osm-5 is expressed and migrates within cilia, substantiate a ciliogenic role for polaris and osm-5, possibly as components of the intraflagellar transport (IFT) system; osm-5 is also required for correct ciliary targeting of lov-1 and pkd-2, genes that are orthologous to human PKD1 and PKD2, which are mutated in human autosomal dominant polycystic kidney disease. | Homo sapiens | Paper_evidence | WBPaper00004603 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 Jan 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000030 | ||||||||
| Models_disease_asserted | WBDOannot00000513 | ||||||||
| Molecular_info | Corresponding_CDS | Y41G9A.1 | |||||||
| Corresponding_transcript | Y41G9A.1.1 | ||||||||
| Other_sequence (25) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00095205 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056418 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00006237 | ||||||||
| WBCnstr00008467 | |||||||||
| WBCnstr00009069 | |||||||||
| WBCnstr00010229 | |||||||||
| WBCnstr00013368 | |||||||||
| WBCnstr00039933 | |||||||||
| Antibody | WBAntibody00000351 | ||||||||
| WBAntibody00001248 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (200) | |||||||||
| Interaction (43) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000012 | |||||||||
| Map_info | Map | X | Position | -12.6622 | Error | 0.00141 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y41G9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 376 | |||||||
| 377 | |||||||||
| 3384 | |||||||||
| Multi_point | 1209 | ||||||||
| 1210 | |||||||||
| 1211 | |||||||||
| 1212 | |||||||||
| 5291 | |||||||||
| 5597 | |||||||||
| Pos_neg_data | 3180 | ||||||||
| 5450 | |||||||||
| Reference (105) | |||||||||
| Remark | Sequence connection from [Haycroft CG, Thomas JH] | ||||||||
| Data extracted from Haycraft et al (2001) | |||||||||
| Method | Gene |
