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WormBase Tree Display for Gene: WBGene00003889

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Name Class

WBGene00003889SMapS_parentSequenceB0212
IdentityVersion1
NameCGC_nameosm-9Person_evidenceWBPerson242
Sequence_nameB0212.5
Molecular_nameB0212.5
B0212.5.1
CE20445
Other_namenss-2
CELE_B0212.5Accession_evidenceNDBBX284604
Public_nameosm-9
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classosm
Allele (120)
Legacy_information[C.elegansII] n1601 : defective in osmotic avoidance, also in nose touch avoidance (Not); Adp (partly defective adaptation to isoamyl alcohol and butanone); normal chemotaxis.OA5: n1516, n1603, n2473, ky10 (similar). [Colbert & Bargmann 1995; JT; KP; MT]
StrainWBStrain00023453
WBStrain00036458
WBStrain00005214
WBStrain00007483
WBStrain00052609
RNASeq_FPKM (74)
GO_annotation (33)
Ortholog (45)
ParalogWBGene00003838Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003839Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003840Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003841Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionosm-9 encodes a TRPV channel homologous to capsaicin receptors; osm-9 is involved in sensory responses to a subset of chemical stimuli and to ASH neuron-mediated osmotic and mechanical stimuli; OSM-9 is also involved in adaptation to volatile odorants and salts; OSM-9 is expressed in a variety of sensory neurons and shows neuron-specific localization to either the cell body or the cilium.Paper_evidenceWBPaper00002166
WBPaper00002930
WBPaper00005150
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated20 Apr 2011 00:00:00
Automated_descriptionEnables calcium channel activity and temperature-gated cation channel activity. Involved in several processes, including heat acclimation; negative adaptation of signaling pathway; and nervous system process. Located in neuronal cell body; non-motile cilium; and perinuclear region of cytoplasm. Expressed in RIG; head mesodermal cell; rectal gland cell; sensory neurons; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including keratosis (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Is an ortholog of human TRPV3 (transient receptor potential cation channel subfamily V member 3); TRPV4 (transient receptor potential cation channel subfamily V member 4); and TRPV5 (transient receptor potential cation channel subfamily V member 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (17)
Molecular_infoCorresponding_CDSB0212.5
Corresponding_transcriptB0212.5.1
Other_sequence (14)
Associated_featureWBsf667839
WBsf995982
Experimental_infoRNAi_result (14)
Expr_pattern (12)
Drives_constructWBCnstr00000837
WBCnstr00005979
WBCnstr00008561
WBCnstr00010985
WBCnstr00010991
WBCnstr00011000
WBCnstr00011004
WBCnstr00012945
WBCnstr00023098
WBCnstr00035811
Construct_productWBCnstr00000837
WBCnstr00006801
WBCnstr00010991
WBCnstr00011000
WBCnstr00011004
WBCnstr00012945
WBCnstr00020618
WBCnstr00035811
Regulate_expr_clusterWBPaper00049594:osm-9(ok1677)_NaCl(200mM)_upregulate
WBPaper00049594:osm-9(ok1677)_upregulated
Microarray_results (18)
Expression_clusterWBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:all-neurons_larva_SelectivelyEnriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_embryo_enriched
WBPaper00037950:dopaminergic-neurons_embryo_SelectivelyEnriched
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_larva_enriched
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00046805:csr-1(RNAi)_upregulated_Set2
WBPaper00046805:P-granule-RNAi_upregulated_Set1
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056161:male_enriched_siRNA
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:cfp-1(tm6369)_upregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059334:sacy-1(depletion)_regulated
WBPaper00059471:EGL-43_interacting
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060921:tph-1(mg280)_upregulated
WBPaper00061040:eat-2(ad1116)_upregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061340:AWA
WBPaper00061340:OLQ
WBPaper00061340:PVP
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:sre-33-ZK1025.1_8337
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062146:MOG-7-degron_2h_regulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00064871:hypoxia_downregulated_F1
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065258:anchor-cell_enriched
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065841:50_0
WBPaper00065841:72_0
WBPaper00065841:106_0
WBPaper00066232:hsf-1(RNAi)_upregulated_WT
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
[cgc5376]:let-60(G12V)-regulated_genes
Interaction (116)
Anatomy_functionWBbtf0291
WBProcessWBbiopr:00000002
Map_infoMapIVPosition-3.15659Error0.016734
Well_ordered
PositivePositive_cloneB0212Inferred_automaticallyFrom sequence, transcript, pseudogene data
CX#2-12
Mapping_data2_point3729
3730
Multi_point1365
1366
Reference (225)
RemarkPossibly homologous to mammalian capsaicin receptor VR1. Some osm-9 mutants are sensitive to capsaicin.[bionet.celegans from Olsen]Curator_confirmedWBPerson1250
MethodGene