WormBase Tree Display for Gene: WBGene00003889

WBGene00003889 SMap: S_parent: Sequence: B0212
  Identity: Version: 1
    Name: CGC_name: osm-9 Person_evidence: WBPerson242
      Sequence_name: B0212.5
      Molecular_name: B0212.5
        B0212.5.1
        CE20445
      Other_name: nss-2
        CELE_B0212.5 Accession_evidence: NDB BX284604
      Public_name: osm-9
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: osm
    Allele (120)
    Legacy_information: [C.elegansII] n1601 : defective in osmotic avoidance, also in nose touch avoidance (Not); Adp (partly defective adaptation to isoamyl alcohol and butanone); normal chemotaxis.OA5: n1516, n1603, n2473, ky10 (similar). [Colbert & Bargmann 1995; JT; KP; MT]
    Strain: WBStrain00023453
      WBStrain00036458
      WBStrain00005214
      WBStrain00007483
      WBStrain00052609
    RNASeq_FPKM (74)
    GO_annotation (33)
    Ortholog (45)
    Paralog: WBGene00003838 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003839 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003840 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003841 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: osm-9 encodes a TRPV channel homologous to capsaicin receptors; osm-9 is involved in sensory responses to a subset of chemical stimuli and to ASH neuron-mediated osmotic and mechanical stimuli; OSM-9 is also involved in adaptation to volatile odorants and salts; OSM-9 is expressed in a variety of sensory neurons and shows neuron-specific localization to either the cell body or the cilium. Paper_evidence: WBPaper00002166
            WBPaper00002930
            WBPaper00005150
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 20 Apr 2011 00:00:00
      Automated_description: Enables calcium channel activity and temperature-gated cation channel activity. Involved in several processes, including heat acclimation; negative adaptation of signaling pathway; and nervous system process. Located in neuronal cell body; non-motile cilium; and perinuclear region of cytoplasm. Expressed in RIG; head mesodermal cell; rectal gland cell; sensory neurons; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including keratosis (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Is an ortholog of human TRPV3 (transient receptor potential cation channel subfamily V member 3); TRPV4 (transient receptor potential cation channel subfamily V member 4); and TRPV5 (transient receptor potential cation channel subfamily V member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (17)
  Molecular_info: Corresponding_CDS: B0212.5
    Corresponding_transcript: B0212.5.1
    Other_sequence (14)
    Associated_feature: WBsf667839
      WBsf995982
  Experimental_info: RNAi_result (14)
    Expr_pattern (12)
    Drives_construct: WBCnstr00000837
      WBCnstr00005979
      WBCnstr00008561
      WBCnstr00010985
      WBCnstr00010991
      WBCnstr00011000
      WBCnstr00011004
      WBCnstr00012945
      WBCnstr00023098
      WBCnstr00035811
    Construct_product: WBCnstr00000837
      WBCnstr00006801
      WBCnstr00010991
      WBCnstr00011000
      WBCnstr00011004
      WBCnstr00012945
      WBCnstr00020618
      WBCnstr00035811
    Regulate_expr_cluster: WBPaper00049594:osm-9(ok1677)_NaCl(200mM)_upregulate
      WBPaper00049594:osm-9(ok1677)_upregulated
    Microarray_results (18)
    Expression_cluster (103)
    Interaction (116)
    Anatomy_function: WBbtf0291
    WBProcess: WBbiopr:00000002
  Map_info: Map: IV Position: -3.15659 Error: 0.016734
    Well_ordered
    Positive: Positive_clone: B0212 Inferred_automatically: From sequence, transcript, pseudogene data
        CX#2-12
    Mapping_data: 2_point: 3729
        3730
      Multi_point: 1365
        1366
  Reference: WBPaper00002166
    WBPaper00002810
    WBPaper00002917
    WBPaper00002930
    WBPaper00003024
    WBPaper00003300
    WBPaper00003408
    WBPaper00003455
    WBPaper00003727
    WBPaper00003824
    WBPaper00003894
    WBPaper00003977
    WBPaper00004854
    WBPaper00005148
    WBPaper00005150
    WBPaper00005242
    WBPaper00005350
    WBPaper00005511
    WBPaper00005666
    WBPaper00005787
    WBPaper00005849
    WBPaper00006103
    WBPaper00006166
    WBPaper00006251
    WBPaper00006402
    WBPaper00006505
    WBPaper00010767
    WBPaper00011483
    WBPaper00011634
    WBPaper00011921
    WBPaper00013467
    WBPaper00013472
    WBPaper00013487
    WBPaper00014526
    WBPaper00016622
    WBPaper00016938
    WBPaper00016979
    WBPaper00017214
    WBPaper00017252
    WBPaper00017411
    WBPaper00017682
    WBPaper00017683
    WBPaper00017780
    WBPaper00017783
    WBPaper00017784
    WBPaper00017785
    WBPaper00017974
    WBPaper00017991
    WBPaper00018003
    WBPaper00018849
    WBPaper00018893
    WBPaper00018949
    WBPaper00019186
    WBPaper00019206
    WBPaper00019327
    WBPaper00022232
    WBPaper00022691
    WBPaper00022713
    WBPaper00022768
    WBPaper00023030
    WBPaper00023079
    WBPaper00023170
    WBPaper00023282
    WBPaper00023490
    WBPaper00023726
    WBPaper00023923
    WBPaper00023954
    WBPaper00024097
    WBPaper00024894
    WBPaper00024918
    WBPaper00024990
    WBPaper00025243
    WBPaper00025339
    WBPaper00025456
    WBPaper00025902
    WBPaper00026130
    WBPaper00026667
    WBPaper00026822
    WBPaper00026874
    WBPaper00026896
    WBPaper00026897
    WBPaper00027029
    WBPaper00027202
    WBPaper00027280
    WBPaper00027386
    WBPaper00027506
    WBPaper00027661
    WBPaper00027760
    WBPaper00028339
    WBPaper00028350
    WBPaper00028636
    WBPaper00028739
    WBPaper00028909
    WBPaper00028963
    WBPaper00028992
    WBPaper00029013
    WBPaper00029015
    WBPaper00029016
    WBPaper00029060
    WBPaper00029063
    WBPaper00029178
    WBPaper00029313
    WBPaper00030161
    WBPaper00030175
    WBPaper00030190
    WBPaper00030499
    WBPaper00030843
    WBPaper00031133
    WBPaper00031146
    WBPaper00031243
    WBPaper00031624
    WBPaper00031681
    WBPaper00031834
    WBPaper00031883
    WBPaper00031935
    WBPaper00031936
    WBPaper00032000
    WBPaper00032215
    WBPaper00032346
    WBPaper00032428
    WBPaper00032501
    WBPaper00032791
    WBPaper00032939
    WBPaper00033037
    WBPaper00033128
    WBPaper00033168
    WBPaper00033323
    WBPaper00033392
    WBPaper00034132
    WBPaper00034134
    WBPaper00035058
    WBPaper00035071
    WBPaper00035348
    WBPaper00035581
    WBPaper00035961
    WBPaper00036100
    WBPaper00036504
    WBPaper00036554
    WBPaper00036912
    WBPaper00037156
    WBPaper00037771
    WBPaper00037836
    WBPaper00038142
    WBPaper00038491
    WBPaper00039098
    WBPaper00039398
    WBPaper00039411
    WBPaper00039426
    WBPaper00039558
    WBPaper00039982
    WBPaper00040013
    WBPaper00040014
    WBPaper00040015
    WBPaper00040144
    WBPaper00040829
    WBPaper00040879
    WBPaper00041112
    WBPaper00041243
    WBPaper00041946
    WBPaper00043370
    WBPaper00043558
    WBPaper00043853
    WBPaper00043891
    WBPaper00043908
    WBPaper00044120
    WBPaper00044210
    WBPaper00044524
    WBPaper00044578
    WBPaper00044898
    WBPaper00045423
    WBPaper00045595
    WBPaper00045720
    WBPaper00046660
    WBPaper00047779
    WBPaper00047887
    WBPaper00048251
    WBPaper00048410
    WBPaper00049594
    WBPaper00049733
    WBPaper00049770
    WBPaper00050085
    WBPaper00050233
    WBPaper00050413
    WBPaper00050777
    WBPaper00052358
    WBPaper00052494
    WBPaper00053730
    WBPaper00054463
    WBPaper00055090
    WBPaper00055271
    WBPaper00055659
    WBPaper00056744
    WBPaper00058080
    WBPaper00058277
    WBPaper00058357
    WBPaper00058395
    WBPaper00058803
    WBPaper00059397
    WBPaper00059550
    WBPaper00059779
    WBPaper00059946
    WBPaper00060536
    WBPaper00060538
    WBPaper00060627
    WBPaper00060642
    WBPaper00060701
    WBPaper00060742
    WBPaper00060840
    WBPaper00061436
    WBPaper00061945
    WBPaper00062213
    WBPaper00062495
    WBPaper00062883
    WBPaper00063119
    WBPaper00063284
    WBPaper00063668
    WBPaper00063944
    WBPaper00063946
    WBPaper00064026
    WBPaper00064652
    WBPaper00064660
    WBPaper00064749
    WBPaper00064992
    WBPaper00065019
    WBPaper00065100
  Remark: Possibly homologous to mammalian capsaicin receptor VR1. Some osm-9 mutants are sensitive to capsaicin.[bionet.celegans from Olsen] Curator_confirmed: WBPerson1250
  Method: Gene