WormBase Tree Display for Gene: WBGene00004729
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| WBGene00004729 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sax-3 | Person_evidence | WBPerson42 | |||||
| Sequence_name | ZK377.2 | ||||||||
| Molecular_name | ZK377.2a | ||||||||
| ZK377.2a.1 | |||||||||
| CE25688 | |||||||||
| ZK377.2b | |||||||||
| CE31267 | |||||||||
| ZK377.2b.1 | |||||||||
| Other_name | CELE_ZK377.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sax-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303098 | ||||
| Split_into | WBGene00303098 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sax | ||||||||
| Allele (171) | |||||||||
| Legacy_information | [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2 | ||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (50) | |||||||||
| Paralog (22) | |||||||||
| Structured_description | Concise_description | sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. | Paper_evidence | WBPaper00003665 | |||||
| WBPaper00004362 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 24 Jan 2008 00:00:00 | ||||||||
| Automated_description | Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (11) | ||||||||
| Molecular_info | Corresponding_CDS | ZK377.2a | |||||||
| ZK377.2b | |||||||||
| Corresponding_CDS_history | ZK377.2c:wp264 | ||||||||
| Corresponding_transcript | ZK377.2a.1 | ||||||||
| ZK377.2b.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf670328 | ||||||||
| WBsf670329 | |||||||||
| WBsf670330 | |||||||||
| WBsf670331 | |||||||||
| WBsf670332 | |||||||||
| WBsf670333 | |||||||||
| WBsf670334 | |||||||||
| WBsf670335 | |||||||||
| WBsf670336 | |||||||||
| WBsf670337 | |||||||||
| WBsf670338 | |||||||||
| WBsf670339 | |||||||||
| WBsf670340 | |||||||||
| WBsf1004619 | |||||||||
| WBsf1004620 | |||||||||
| WBsf1004621 | |||||||||
| WBsf1004622 | |||||||||
| WBsf1004623 | |||||||||
| WBsf1004624 | |||||||||
| WBsf1004625 | |||||||||
| WBsf1004626 | |||||||||
| WBsf1004627 | |||||||||
| WBsf1004628 | |||||||||
| WBsf1004629 | |||||||||
| WBsf1004630 | |||||||||
| WBsf1004631 | |||||||||
| WBsf1004632 | |||||||||
| WBsf1004633 | |||||||||
| WBsf1022612 | |||||||||
| WBsf1022613 | |||||||||
| WBsf1022614 | |||||||||
| WBsf1022615 | |||||||||
| WBsf1022616 | |||||||||
| WBsf1022617 | |||||||||
| WBsf1022618 | |||||||||
| WBsf1022619 | |||||||||
| WBsf1022620 | |||||||||
| WBsf1022621 | |||||||||
| WBsf237183 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00086088 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00086133 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009468 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009467 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067130 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059385 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (17) | |||||||||
| Drives_construct | WBCnstr00001914 | ||||||||
| WBCnstr00003185 | |||||||||
| WBCnstr00006455 | |||||||||
| WBCnstr00009445 | |||||||||
| WBCnstr00012503 | |||||||||
| WBCnstr00016209 | |||||||||
| WBCnstr00035424 | |||||||||
| WBCnstr00039977 | |||||||||
| WBCnstr00041184 | |||||||||
| Construct_product (15) | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (134) | |||||||||
| Interaction (262) | |||||||||
| Anatomy_function | WBbtf0177 | ||||||||
| Map_info | Map | X | Position | -10.3398 | Error | 0.007528 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDp57 | |||||||
| Positive_clone | R06A1 | ||||||||
| ZK377 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 3695 | |||||||
| 3696 | |||||||||
| 4758 | |||||||||
| Pos_neg_data | 9401 | ||||||||
| Reference (143) | |||||||||
| Remark | Inferred from Zallen et al. (1998) | ||||||||
| 2 predicted genes (see phenotype) have been merged. [sdm 05/00] | |||||||||
| Method | Gene |
