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WormBase Tree Display for Gene: WBGene00004729

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Name Class

WBGene00004729SMapS_parentSequenceCHROMOSOME_X
IdentityVersion2
NameCGC_namesax-3Person_evidenceWBPerson42
Sequence_nameZK377.2
Molecular_nameZK377.2a
ZK377.2a.1
CE25688
ZK377.2b
CE31267
ZK377.2b.1
Other_nameCELE_ZK377.2Accession_evidenceNDBBX284606
Public_namesax-3
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
202 Mar 2018 11:09:16WBPerson4025EventSplit_intoWBGene00303098
Split_intoWBGene00303098
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsax
Allele (171)
Legacy_information[Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2
Strain (11)
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (50)
Paralog (22)
Structured_descriptionConcise_descriptionsax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance.Paper_evidenceWBPaper00003665
WBPaper00004362
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated24 Jan 2008 00:00:00
Automated_descriptionEnables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (11)
Molecular_infoCorresponding_CDSZK377.2a
ZK377.2b
Corresponding_CDS_historyZK377.2c:wp264
Corresponding_transcriptZK377.2a.1
ZK377.2b.1
Other_sequence (32)
Associated_feature (39)
Experimental_infoRNAi_resultWBRNAi00086088Inferred_automaticallyRNAi_primary
WBRNAi00086133Inferred_automaticallyRNAi_primary
WBRNAi00009468Inferred_automaticallyRNAi_primary
WBRNAi00009467Inferred_automaticallyRNAi_primary
WBRNAi00067130Inferred_automaticallyRNAi_primary
WBRNAi00059385Inferred_automaticallyRNAi_primary
Expr_pattern (17)
Drives_constructWBCnstr00001914
WBCnstr00003185
WBCnstr00006455
WBCnstr00009445
WBCnstr00012503
WBCnstr00016209
WBCnstr00035424
WBCnstr00039977
WBCnstr00041184
Construct_product (15)
Microarray_results (28)
Expression_cluster (134)
InteractionWBInteraction000001176
WBInteraction000001444
WBInteraction000001445
WBInteraction000001854
WBInteraction000001856
WBInteraction000002382
WBInteraction000002383
WBInteraction000002430
WBInteraction000003040
WBInteraction000005252
WBInteraction000005444
WBInteraction000006584
WBInteraction000008783
WBInteraction000009325
WBInteraction000009345
WBInteraction000009360
WBInteraction000009499
WBInteraction000028579
WBInteraction000029295
WBInteraction000029405
WBInteraction000029455
WBInteraction000029621
WBInteraction000030129
WBInteraction000032535
WBInteraction000032685
WBInteraction000032686
WBInteraction000033075
WBInteraction000033156
WBInteraction000033168
WBInteraction000033329
WBInteraction000033339
WBInteraction000033343
WBInteraction000033397
WBInteraction000033450
WBInteraction000033459
WBInteraction000033463
WBInteraction000033694
WBInteraction000033770
WBInteraction000033839
WBInteraction000033914
WBInteraction000034061
WBInteraction000034062
WBInteraction000034997
WBInteraction000035150
WBInteraction000035183
WBInteraction000035185
WBInteraction000035313
WBInteraction000035741
WBInteraction000035997
WBInteraction000036453
WBInteraction000036661
WBInteraction000037260
WBInteraction000037723
WBInteraction000037724
WBInteraction000038537
WBInteraction000038659
WBInteraction000038660
WBInteraction000039029
WBInteraction000039043
WBInteraction000039069
WBInteraction000042777
WBInteraction000042778
WBInteraction000042779
WBInteraction000043442
WBInteraction000043726
WBInteraction000043743
WBInteraction000043744
WBInteraction000044410
WBInteraction000045170
WBInteraction000045312
WBInteraction000046180
WBInteraction000046843
WBInteraction000048911
WBInteraction000049610
WBInteraction000049850
WBInteraction000050197
WBInteraction000052826
WBInteraction000052838
WBInteraction000113766
WBInteraction000115676
WBInteraction000119186
WBInteraction000122038
WBInteraction000126320
WBInteraction000126718
WBInteraction000126725
WBInteraction000127116
WBInteraction000133259
WBInteraction000133307
WBInteraction000135720
WBInteraction000136319
WBInteraction000137537
WBInteraction000144307
WBInteraction000144317
WBInteraction000148735
WBInteraction000153227
WBInteraction000153229
WBInteraction000165085
WBInteraction000165466
WBInteraction000165564
WBInteraction000165748
WBInteraction000165869
WBInteraction000165875
WBInteraction000166450
WBInteraction000171197
WBInteraction000171287
WBInteraction000175067
WBInteraction000178795
WBInteraction000179852
WBInteraction000180408
WBInteraction000188267
WBInteraction000192029
WBInteraction000195349
WBInteraction000197091
WBInteraction000197129
WBInteraction000198609
WBInteraction000202364
WBInteraction000202997
WBInteraction000205104
WBInteraction000209960
WBInteraction000210549
WBInteraction000214407
WBInteraction000221363
WBInteraction000222083
WBInteraction000227006
WBInteraction000227726
WBInteraction000228203
WBInteraction000231003
WBInteraction000231471
WBInteraction000232976
WBInteraction000233355
WBInteraction000251426
WBInteraction000251443
WBInteraction000256395
WBInteraction000262292
WBInteraction000269006
WBInteraction000270676
WBInteraction000270721
WBInteraction000273892
WBInteraction000274695
WBInteraction000275210
WBInteraction000281209
WBInteraction000282292
WBInteraction000283554
WBInteraction000284733
WBInteraction000286284
WBInteraction000292183
WBInteraction000292800
WBInteraction000293826
WBInteraction000294840
WBInteraction000297652
WBInteraction000299369
WBInteraction000300191
WBInteraction000301653
WBInteraction000301750
WBInteraction000303009
WBInteraction000307500
WBInteraction000310054
WBInteraction000311830
WBInteraction000319431
WBInteraction000327933
WBInteraction000331348
WBInteraction000331869
WBInteraction000333459
WBInteraction000334224
WBInteraction000341591
WBInteraction000342163
WBInteraction000345379
WBInteraction000353079
WBInteraction000355667
WBInteraction000357345
WBInteraction000364907
WBInteraction000368756
WBInteraction000371865
WBInteraction000373288
WBInteraction000373748
WBInteraction000374212
WBInteraction000386175
WBInteraction000387218
WBInteraction000390459
WBInteraction000390805
WBInteraction000395086
WBInteraction000399465
WBInteraction000400066
WBInteraction000401280
WBInteraction000403153
WBInteraction000404335
WBInteraction000407825
WBInteraction000410990
WBInteraction000413558
WBInteraction000414750
WBInteraction000414987
WBInteraction000416042
WBInteraction000423812
WBInteraction000426553
WBInteraction000428974
WBInteraction000432111
WBInteraction000436450
WBInteraction000439642
WBInteraction000441847
WBInteraction000443269
WBInteraction000445249
WBInteraction000445364
WBInteraction000446825
WBInteraction000447885
WBInteraction000449295
WBInteraction000451001
WBInteraction000451553
WBInteraction000454167
WBInteraction000457590
WBInteraction000469594
WBInteraction000470992
WBInteraction000503563
WBInteraction000503564
WBInteraction000503919
WBInteraction000503920
WBInteraction000518369
WBInteraction000518560
WBInteraction000518896
WBInteraction000518899
WBInteraction000523853
WBInteraction000540340
WBInteraction000540355
WBInteraction000540743
WBInteraction000540744
WBInteraction000540745
WBInteraction000540746
WBInteraction000551250
WBInteraction000551251
WBInteraction000551253
WBInteraction000551296
WBInteraction000551357
WBInteraction000551358
WBInteraction000555534
WBInteraction000555700
WBInteraction000556289
WBInteraction000556752
WBInteraction000559982
WBInteraction000559983
WBInteraction000559984
WBInteraction000570692
WBInteraction000570693
WBInteraction000570694
WBInteraction000570695
WBInteraction000570696
WBInteraction000570697
WBInteraction000570698
WBInteraction000570699
WBInteraction000570700
WBInteraction000570701
WBInteraction000570702
WBInteraction000570703
WBInteraction000570704
WBInteraction000570705
WBInteraction000570706
WBInteraction000570707
WBInteraction000570708
WBInteraction000570709
WBInteraction000570710
WBInteraction000570711
WBInteraction000570712
WBInteraction000570713
WBInteraction000578721
Anatomy_functionWBbtf0177
Map_infoMapXPosition-10.3398Error0.007528
Well_ordered
PositiveInside_rearrmnDp57
Positive_cloneR06A1
ZK377Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point3695
3696
4758
Pos_neg_data9401
Reference (143)
RemarkInferred from Zallen et al. (1998)
2 predicted genes (see phenotype) have been merged. [sdm 05/00]
MethodGene