WormBase Tree Display for Gene: WBGene00004729
expand all nodes | collapse all nodes | view schema
WBGene00004729 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | sax-3 | Person_evidence | WBPerson42 | |||
Sequence_name | ZK377.2 | ||||||
Molecular_name | ZK377.2a | ||||||
ZK377.2a.1 | |||||||
CE25688 | |||||||
ZK377.2b | |||||||
CE31267 | |||||||
ZK377.2b.1 | |||||||
Other_name | CELE_ZK377.2 | Accession_evidence | NDB | BX284606 | |||
Public_name | sax-3 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sax | ||||||
Allele (171) | |||||||
Legacy_information | [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2 | ||||||
Strain (11) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (50) | |||||||
Paralog (22) | |||||||
Structured_description | Concise_description | sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. | Paper_evidence | WBPaper00003665 | |||
WBPaper00004362 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 24 Jan 2008 00:00:00 | ||||||
Automated_description | Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (11) | ||||||
Molecular_info | Corresponding_CDS | ZK377.2a | |||||
ZK377.2b | |||||||
Corresponding_CDS_history | ZK377.2c:wp264 | ||||||
Corresponding_transcript | ZK377.2a.1 | ||||||
ZK377.2b.1 | |||||||
Other_sequence (32) | |||||||
Associated_feature (39) | |||||||
Experimental_info | RNAi_result | WBRNAi00086088 | Inferred_automatically | RNAi_primary | |||
WBRNAi00086133 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009468 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009467 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00067130 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059385 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (17) | |||||||
Drives_construct | WBCnstr00001914 | ||||||
WBCnstr00003185 | |||||||
WBCnstr00006455 | |||||||
WBCnstr00009445 | |||||||
WBCnstr00012503 | |||||||
WBCnstr00016209 | |||||||
WBCnstr00035424 | |||||||
WBCnstr00039977 | |||||||
WBCnstr00041184 | |||||||
Construct_product (15) | |||||||
Microarray_results (28) | |||||||
Expression_cluster (134) | |||||||
Interaction (262) | |||||||
Anatomy_function | WBbtf0177 | ||||||
Map_info | Map | X | Position | -10.3398 | Error | 0.007528 | |
Well_ordered | |||||||
Positive | Inside_rearr | mnDp57 | |||||
Positive_clone | R06A1 | ||||||
ZK377 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 3695 | |||||
3696 | |||||||
4758 | |||||||
Pos_neg_data | 9401 | ||||||
Reference (143) | |||||||
Remark | Inferred from Zallen et al. (1998) | ||||||
2 predicted genes (see phenotype) have been merged. [sdm 05/00] | |||||||
Method | Gene |