WormBase Tree Display for Gene: WBGene00004776
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| WBGene00004776 | SMap | S_parent | Sequence | F59C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ser-1 | Person_evidence | WBPerson32 | |||||
| Sequence_name | F59C12.2 | ||||||||
| Molecular_name | F59C12.2a | ||||||||
| F59C12.2a.1 | |||||||||
| CE28481 | |||||||||
| F59C12.2b | |||||||||
| CE38526 | |||||||||
| F59C12.2b.1 | |||||||||
| Other_name | 5-HT2CeL | Accession_evidence | EMBL | AF031414 | |||||
| AF031415 | |||||||||
| 5-HT2CeS | Accession_evidence | EMBL | AF031414 | ||||||
| AF031415 | |||||||||
| CELE_F59C12.2 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | ser-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00004776 | |||||
| WormFlux | gene | WBGene00004776 | |||||||
| NDB | locus_tag | CELE_F59C12.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004776|UniProtKB=O17470 | |||||||
| family | PTHR24247 | ||||||||
| NCBI | gene | 181716 | |||||||
| RefSeq | protein | NM_001029557.5 | |||||||
| NM_001029558.5 | |||||||||
| TREEFAM | TREEFAM_ID | TF351745 | |||||||
| TrEMBL | UniProtAcc | O17470 | |||||||
| G5ECV2 | |||||||||
| UniProt_GCRP | UniProtAcc | O17470 | |||||||
| OMIM | gene | 182135 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ser | ||||||||
| Allele (103) | |||||||||
| Legacy_information | [Leon Avery] ad1675 deletes bp 3708-5921 of F59C12.2. This is predicted to remove the C terminal cytoplasmic tail, but could still leave the protein functional. ad1675 mutants have no obvious phenotype. | ||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (20) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | ser-1 encodes a putative ortholog of mammalian 5-HT2 metabotropicserotonin receptors; SER-1 is required in both vulval muscle and neuronsfor the stimulation of egg-laying by serotonin (5-HT), but is completelydispensable for stimulation by the uptake inhibitor fluoxetine, andmostly dispensable for stimulation by the tricyclic antidepressantimipramine; SER-1 and SER-7 are redundantly required for normalegg-laying; SER-1 is required for normal turning during male mating, andser-1 mutants show reduced male tail curling in exogenous 5-HT, butser-1 males retain mating ability in the laboratory; SER-1 is weaklyrequired for pharyngeal pumping; SER-1 is expressed in diverse neurons(head, nerve ring, vulval, ventral cord motoneurons, tail, and manyothers), in diverse muscles (pharyngeal, vulval, and male-specificdiagonal), and in uterine cells; stimulation of heterologously expressedSER-1 induces a rise in free intracellular calcium; SER-1 has lowaffinity for 5-HT, and a mixture of pharmacological similarities tomammalian 5-HT1 and 5-HT2 receptors; SER-1 is stimulated byalpha-methyl-5HT, and probably antagonized by methiotheptin; SER-1 iscoexpressed with MPZ-1, has a PDZ binding motif (ETFL) that aids itssignalling, and binds PDZ domain 10 of MPZ-1 in vitro; SER-1'sstimulation of egg-laying is impeded by mpz-1(RNAi), if and only ifSER-1's ETFL motif is intact; mod-1;ser-1 double mutants subtly overbendtheir bodies while moving backward. | Paper_evidence (11) | ||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 20 Dec 2006 00:00:00 | ||||||||
| Automated_description | Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in several processes, including reproductive behavior; response to heat; and signal transduction. Located in plasma membrane. Expressed in several structures, including egg-laying apparatus; intestine; neurons; pharyngeal muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; and obsessive-compulsive disorder. Is an ortholog of human HTR2A (5-hydroxytryptamine receptor 2A) and HTR2B (5-hydroxytryptamine receptor 2B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (16) | ||||||||
| Molecular_info | Corresponding_CDS | F59C12.2a | |||||||
| F59C12.2b | |||||||||
| Corresponding_CDS_history | F59C12.2:wp142 | ||||||||
| Corresponding_transcript | F59C12.2a.1 | ||||||||
| F59C12.2b.1 | |||||||||
| Other_sequence (19) | |||||||||
| Associated_feature (19) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct (14) | |||||||||
| Construct_product | WBCnstr00007173 | ||||||||
| WBCnstr00007174 | |||||||||
| WBCnstr00007175 | |||||||||
| WBCnstr00007176 | |||||||||
| WBCnstr00012947 | |||||||||
| WBCnstr00017194 | |||||||||
| WBCnstr00022944 | |||||||||
| WBCnstr00022950 | |||||||||
| WBCnstr00023051 | |||||||||
| WBCnstr00035395 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (88) | |||||||||
| Interaction (94) | |||||||||
| Anatomy_function | WBbtf0587 | ||||||||
| WBbtf0588 | |||||||||
| Map_info | Map | X | Position | 24.0554 | Error | 0.000961 | |||
| Positive | Positive_clone | F59C12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4654 | |||||||
| 5309 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (84) | |||||||||
| Remark | sca-1 has sometimes been used to refer to his gene, but this is not correct as sca-1 is a SERCA (Sarco-Endoplasmic Reticulum Calcium ATPase) | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
