WormBase Tree Display for Gene: WBGene00006352

WBGene00006352 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: sur-6 Person_evidence: WBPerson237
      Sequence_name: F26E4.1
      Molecular_name: F26E4.1
        F26E4.1.1
        CE09685
      Other_name: CELE_F26E4.1 Accession_evidence: NDB BX284601
      Public_name: sur-6
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sur
    Allele (58)
    Legacy_information: [Sieburth DS] sur for suppressor of ras. suppresses the multivulva phenotype caused by let-60(n1046gf). ku123 causes no phenotype. ku123 is dominant
    Strain: WBStrain00001777
      WBStrain00026511
      WBStrain00026525
      WBStrain00035415
      WBStrain00037362
      WBStrain00007339
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (52)
    Structured_description: Concise_description: sur-6 encodes a regulatory (B) subunit of serine/threonine protein phosphatase 2A (PP2A-B); sur-6 was initially identified in screens for mutations that suppress the Multivulva phenotype produced by an activated let-60/Ras mutation and enhance the vulvaless and larval lethality phenotype of a hypomorphic lin-45/Raf mutation; in addition, RNAi experiments demonstrate that sur-6 activity is also essential for embryonic development; genetic studies indicate that during vulval development SUR-6 likely acts with the KSR-1 kinase in a parallel pathway that positively regulates RTK-Ras-MAP kinase signaling. Paper_evidence: WBPaper00003726
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Apr 2008 00:00:00
      Automated_description: Predicted to enable protein phosphatase regulator activity. Involved in embryo development; nematode larval development; and positive regulation of vulval development. Predicted to be located in cytosol. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; spinocerebellar ataxia type 12; and systemic lupus erythematosus. Is an ortholog of human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:0050962 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:9074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
  Molecular_info: Corresponding_CDS: F26E4.1
    Corresponding_transcript: F26E4.1.1
    Other_sequence (33)
    Associated_feature (14)
  Experimental_info: RNAi_result (42)
    Expr_pattern: Chronogram2080
      Expr5874
      Expr15731
      Expr1017534
      Expr1032559
      Expr1149549
      Expr2017137
      Expr2035273
    Drives_construct: WBCnstr00002590
      WBCnstr00034393
    Construct_product: WBCnstr00034393
    Antibody: WBAntibody00002241
    Microarray_results (22)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045420:fertilization_downregulated_protein
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053615:SMO-1_target
      WBPaper00055648:germline_expressed
      WBPaper00055969:electromagnetic-field_downregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056617:adr-1(tm668)_downregulated_L4_protein
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059174:MEG-3_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:ASE_parent
      WBPaper00061466:nath-10(icb102)_downregulated
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061527:trcs-2_5724-R11A8.7_17645
      WBPaper00062056:lin-36(we31)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00064992:Capsaicin_upregulated
      WBPaper00064992:Eugenol_upregulated
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_15
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_3
      WBPaper00034739:N2moreDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00053827:pyoverdine_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_25
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(53_min)
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_E
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (185)
    WBProcess: WBbiopr:00000071
  Map_info: Map: I Position: 3.89256 Error: 0.002576
    Well_ordered
    Positive: Inside_rearr: qDf8
        qDf9
      Positive_clone: F26E4 Inferred_automatically: From sequence, transcript, pseudogene data
        K02A11
    Negative: Outside_rearr: qDf5
      Negative_clone: F26E4
    Mapping_data: Multi_point: 3575
        4838
        4866
        4802
        4836
      Pos_neg_data: 9160
        9161
        9162
  Reference (42)
  Method: Gene