WormBase Tree Display for Gene: WBGene00006744
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| WBGene00006744 | SMap | S_parent | Sequence | F26C11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-4 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F26C11.2 | ||||||||
| Molecular_name | F26C11.2 | ||||||||
| F26C11.2.1 | |||||||||
| CE01560 | |||||||||
| Other_name | ceh-4 | ||||||||
| CELE_F26C11.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | unc-4 | ||||||||
| DB_info | Database | AceView | gene | 2K188 | |||||
| WormQTL | gene | WBGene00006744 | |||||||
| SignaLink | protein | WBGene00006744 | |||||||
| WormFlux | gene | WBGene00006744 | |||||||
| NDB | locus_tag | CELE_F26C11.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006744|UniProtKB=P29506 | |||||||
| family | PTHR24329 | ||||||||
| NCBI | gene | 174544 | |||||||
| RefSeq | protein | NM_063737.2 | |||||||
| SwissProt | UniProtAcc | P29506 | |||||||
| UniProt_GCRP | UniProtAcc | P29506 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (53) | |||||||||
| Possibly_affected_by | WBVar02152871 | ||||||||
| WBVar02152872 | |||||||||
| WBVar02153037 | |||||||||
| WBVar02153038 | |||||||||
| Legacy_information | e120 : large healthy active moves forward well cannot back; ventral cord VA motoneurons have normal anatomy but synaptic inputs appropriate to VB motoneurons. ES3 ME0. NA5 (e26 etc.). | ||||||||
| See also e2151, e2152, e2314, wd1 | |||||||||
| [C.elegansII] e120 : large, healthy, active, moves forward well but cannot back; ventral cord VA motoneurons have normal anatomy but most have synaptic inputs appropriate to VB motoneurons. ES3 ME1. OA>15: e26, e2151, e2308, e2320 (deletion null,resembles e120), e2322ts (TSP L2-L3),wd1 etc. See also unc-37. Cloned: rare 1.2 kb transcript, encodes homeoprotein (pka ceh-4); unc-4:lacZ expressed in VA but not VB motor neurons. [White et al. 1992; Miller et al. 1992; NC] | |||||||||
| Strain (265) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (30) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | The unc-4 gene encodes a paired-class homeodomain protein with homologs in Drosophila and vertebrates; UNC-4 is required for establishing the identity of the A class motor neurons DA and VA, and is thus required for movement, axon guidance, and synapse formation; UNC-4 is negatively regulated by VAB-7, and UNC-4 activity requires UNC-37; unc-4 is expressed in the A-type motor neurons, DA and VA, the six VC motor neurons that innervate the vulval muscles, and the three SAB motor neurons; unc-4 is also expressed in the pharyngeal I5 motor neuron and the AVF neurons in the retrovesicular ganglion. | Paper_evidence | WBPaper00001502 | |||||
| WBPaper00004594 | |||||||||
| WBPaper00005153 | |||||||||
| WBPaper00005237 | |||||||||
| WBPaper00005455 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Aug 2005 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and synaptic vesicle transport. Located in axon and nucleus. Expressed in I5 neuron; cholinergic neurons; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F26C11.2 | |||||||
| Corresponding_transcript | F26C11.2.1 | ||||||||
| Other_sequence | X64904 | ||||||||
| JI482165.1 | |||||||||
| Oden_isotig24826 | |||||||||
| Acan_isotig12060 | |||||||||
| Dviv_isotig25636 | |||||||||
| JI228715.1 | |||||||||
| Associated_feature | WBsf650466 | ||||||||
| WBsf978893 | |||||||||
| WBsf223725 | |||||||||
| WBsf223726 | |||||||||
| Transcription_factor | WBTranscriptionFactor000320 | ||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct (54) | |||||||||
| Construct_product | WBCnstr00006869 | ||||||||
| WBCnstr00016592 | |||||||||
| WBCnstr00016693 | |||||||||
| WBCnstr00017159 | |||||||||
| WBCnstr00022370 | |||||||||
| WBCnstr00034179 | |||||||||
| Regulate_expr_cluster | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (98) | |||||||||
| Interaction (175) | |||||||||
| Anatomy_function | WBbtf0167 | ||||||||
| WBbtf0168 | |||||||||
| WBbtf0169 | |||||||||
| WBbtf0231 | |||||||||
| Map_info | Map | II | Position | 1.7701 | Error | 0.005634 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr (17) | ||||||||
| Positive_clone | C07E2 | ||||||||
| F26C11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Outside_rearr | mnDp34 | |||||||
| mnDp35 | |||||||||
| mnDp36 | |||||||||
| Mapping_data | 2_point (56) | ||||||||
| Multi_point (247) | |||||||||
| Pos_neg_data (23) | |||||||||
| Landmark_gene | |||||||||
| Reference (293) | |||||||||
| Method | Gene |
