WormBase Tree Display for Gene: WBGene00006745

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WBGene00006745	SMap	S_parent	Sequence	B0273
	Identity	Version	1
		Name	CGC_name	unc-5	Person_evidence	WBPerson261
			Sequence_name	B0273.4
			Molecular_name (19)
			Other_name	CELE_B0273.4	Accession_evidence	NDB	BX284604
			Public_name	unc-5
		DB_info	Database	AceView	gene	4G260
				WormQTL	gene	WBGene00006745
				WormFlux	gene	WBGene00006745
				NDB	locus_tag	CELE_B0273.4
				Panther	gene	CAEEL\|WormBase=WBGene00006745\|UniProtKB=Q26261
					family	PTHR12582
				NCBI	gene	177334
				RefSeq	protein	NM_001392311.1
						NM_068422.6
						NM_001306822.3
						NM_068421.6
						NM_001306820.3
						NM_001380233.1
				SwissProt	UniProtAcc	Q26261
				TREEFAM	TREEFAM_ID	TF316767
				UniProt_GCRP	UniProtAcc	Q26261
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:41	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	unc
		Reference_allele	WBVar00142936
		Allele (350)
		Legacy_information	e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.).
			See also e2349, e2355, e2387
			[C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW]
		Strain (67)
		RNASeq_FPKM (74)
		GO_annotation (53)
		Ortholog (53)
		Structured_description	Concise_description	unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood.	Paper_evidence	WBPaper00001619
						WBPaper00005582
					Curator_confirmed	WBPerson1843
						WBPerson567
					Date_last_updated	25 Jan 2006 00:00:00
			Automated_description	Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	B0273.4a
			B0273.4b
			B0273.4c
			B0273.4d
			B0273.4e
			B0273.4f
		Corresponding_CDS_history	B0273.4b:wp134
		Corresponding_transcript	B0273.4a.1
			B0273.4b.1
			B0273.4c.1
			B0273.4d.1
			B0273.4d.2
			B0273.4e.1
			B0273.4f.1
		Other_sequence	JI475712.1
			JI459463.1
			CR01727
			CRC00510_2
			CRC06468_1
			CR03346
			CJC11776_1
			JI165198.1
			Dviv_isotig23366
		Associated_feature (24)
	Experimental_info	RNAi_result (14)
		Expr_pattern (11)
		Drives_construct (17)
		Construct_product	WBCnstr00000353
			WBCnstr00000576
			WBCnstr00000577
			WBCnstr00005354
			WBCnstr00010750
			WBCnstr00017204
			WBCnstr00018455
			WBCnstr00019874
			WBCnstr00020677
			WBCnstr00020819
			WBCnstr00022893
			WBCnstr00034178
			WBCnstr00038762
		Microarray_results (30)
		Expression_cluster (154)
		Interaction (206)
		WBProcess	WBbiopr:00000025
	Map_info	Map	IV	Position	1.78303	Error	0.002438
		Well_ordered
		Positive	Positive_clone	B0273	Inferred_automatically	From sequence, transcript, pseudogene data
				C37G6	Inferred_automatically	From sequence, transcript, pseudogene data
		Negative	Outside_rearr	nDp5
		Mapping_data	2_point (21)
			Multi_point (96)
			Pos_neg_data	3700
				9031
				9036
				10892
		Landmark_gene
	Reference	WBPaper00000030
		WBPaper00000031
		WBPaper00000079
		WBPaper00000365
		WBPaper00000499
		WBPaper00000608
		WBPaper00000785
		WBPaper00000978
		WBPaper00001019
		WBPaper00001074
		WBPaper00001246
		WBPaper00001296
		WBPaper00001325
		WBPaper00001345
		WBPaper00001424
		WBPaper00001473
		WBPaper00001499
		WBPaper00001501
		WBPaper00001508
		WBPaper00001567
		WBPaper00001619
		WBPaper00001640
		WBPaper00001649
		WBPaper00001679
		WBPaper00001719
		WBPaper00001728
		WBPaper00001758
		WBPaper00001766
		WBPaper00001860
		WBPaper00001906
		WBPaper00002003
		WBPaper00002006
		WBPaper00002159
		WBPaper00002355
		WBPaper00002360
		WBPaper00002378
		WBPaper00002425
		WBPaper00002461
		WBPaper00002464
		WBPaper00002571
		WBPaper00002595
		WBPaper00002604
		WBPaper00002717
		WBPaper00002759
		WBPaper00002838
		WBPaper00002951
		WBPaper00003014
		WBPaper00003058
		WBPaper00003139
		WBPaper00003467
		WBPaper00003642
		WBPaper00003665
		WBPaper00003674
		WBPaper00003679
		WBPaper00003841
		WBPaper00003924
		WBPaper00003949
		WBPaper00003979
		WBPaper00003990
		WBPaper00004146
		WBPaper00004167
		WBPaper00004168
		WBPaper00004263
		WBPaper00004315
		WBPaper00004362
		WBPaper00004380
		WBPaper00004437
		WBPaper00004589
		WBPaper00004770
		WBPaper00005236
		WBPaper00005251
		WBPaper00005386
		WBPaper00005417
		WBPaper00005423
		WBPaper00005582
		WBPaper00005719
		WBPaper00005798
		WBPaper00005809
		WBPaper00006025
		WBPaper00006049
		WBPaper00006103
		WBPaper00006185
		WBPaper00006285
		WBPaper00010072
		WBPaper00010078
		WBPaper00010143
		WBPaper00010218
		WBPaper00010331
		WBPaper00010482
		WBPaper00010582
		WBPaper00010923
		WBPaper00011050
		WBPaper00011062
		WBPaper00011175
		WBPaper00011180
		WBPaper00011271
		WBPaper00011478
		WBPaper00011608
		WBPaper00011856
		WBPaper00012457
		WBPaper00012511
		WBPaper00012631
		WBPaper00012741
		WBPaper00013450
		WBPaper00013705
		WBPaper00013734
		WBPaper00013742
		WBPaper00013743
		WBPaper00013782
		WBPaper00013783
		WBPaper00013789
		WBPaper00013809
		WBPaper00013810
		WBPaper00013812
		WBPaper00013813
		WBPaper00013849
		WBPaper00013905
		WBPaper00013970
		WBPaper00013971
		WBPaper00014050
		WBPaper00014058
		WBPaper00014187
		WBPaper00014220
		WBPaper00014270
		WBPaper00014295
		WBPaper00014394
		WBPaper00014420
		WBPaper00014559
		WBPaper00014610
		WBPaper00014674
		WBPaper00014963
		WBPaper00014966
		WBPaper00015081
		WBPaper00015093
		WBPaper00015094
		WBPaper00015166
		WBPaper00015170
		WBPaper00015171
		WBPaper00015262
		WBPaper00015403
		WBPaper00015522
		WBPaper00015529
		WBPaper00015530
		WBPaper00015558
		WBPaper00015717
		WBPaper00015728
		WBPaper00015741
		WBPaper00015745
		WBPaper00016091
		WBPaper00016140
		WBPaper00016202
		WBPaper00016299
		WBPaper00016316
		WBPaper00016407
		WBPaper00016447
		WBPaper00016465
		WBPaper00016473
		WBPaper00016497
		WBPaper00016533
		WBPaper00016552
		WBPaper00016601
		WBPaper00016750
		WBPaper00016806
		WBPaper00017099
		WBPaper00017102
		WBPaper00017703
		WBPaper00017704
		WBPaper00017709
		WBPaper00017710
		WBPaper00017712
		WBPaper00017713
		WBPaper00018143
		WBPaper00018148
		WBPaper00018249
		WBPaper00018335
		WBPaper00018343
		WBPaper00018581
		WBPaper00018587
		WBPaper00018588
		WBPaper00019060
		WBPaper00019269
		WBPaper00019357
		WBPaper00019581
		WBPaper00019584
		WBPaper00019612
		WBPaper00019620
		WBPaper00020775
		WBPaper00020801
		WBPaper00020835
		WBPaper00020971
		WBPaper00021015
		WBPaper00021705
		WBPaper00021719
		WBPaper00021964
		WBPaper00022018
		WBPaper00022306
		WBPaper00022440
		WBPaper00022441
		WBPaper00022520
		WBPaper00022547
		WBPaper00022582
		WBPaper00022658
		WBPaper00022671
		WBPaper00022702
		WBPaper00022853
		WBPaper00022893
		WBPaper00023024
		WBPaper00023052
		WBPaper00023063
		WBPaper00023156
		WBPaper00023161
		WBPaper00023298
		WBPaper00023377
		WBPaper00023401
		WBPaper00023579
		WBPaper00023826
		WBPaper00024537
		WBPaper00024629
		WBPaper00024722
		WBPaper00024726
		WBPaper00024939
		WBPaper00025141
		WBPaper00025445
		WBPaper00025855
		WBPaper00025893
		WBPaper00025931
		WBPaper00025979
		WBPaper00026419
		WBPaper00026544
		WBPaper00026685
		WBPaper00026866
		WBPaper00026923
		WBPaper00027054
		WBPaper00027091
		WBPaper00027119
		WBPaper00027231
		WBPaper00027237
		WBPaper00027307
		WBPaper00027314
		WBPaper00027391
		WBPaper00027447
		WBPaper00027661
		WBPaper00027888
		WBPaper00027927
		WBPaper00028094
		WBPaper00028376
		WBPaper00028501
		WBPaper00028650
		WBPaper00028729
		WBPaper00029020
		WBPaper00029053
		WBPaper00030158
		WBPaper00030446
		WBPaper00030630
		WBPaper00030970
		WBPaper00031067
		WBPaper00031462
		WBPaper00031543
		WBPaper00031651
		WBPaper00031671
		WBPaper00031828
		WBPaper00031855
		WBPaper00032145
		WBPaper00032163
		WBPaper00032446
		WBPaper00032506
		WBPaper00032595
		WBPaper00032743
		WBPaper00032846
		WBPaper00032907
		WBPaper00033179
		WBPaper00033507
		WBPaper00034182
		WBPaper00034762
		WBPaper00035009
		WBPaper00035198
		WBPaper00035457
		WBPaper00036143
		WBPaper00036313
		WBPaper00036375
		WBPaper00036484
		WBPaper00037175
		WBPaper00037224
		WBPaper00037338
		WBPaper00037965
		WBPaper00037977
		WBPaper00038105
		WBPaper00038491
		WBPaper00038640
		WBPaper00039166
		WBPaper00039181
		WBPaper00040041
		WBPaper00040147
		WBPaper00040284
		WBPaper00040894
		WBPaper00041029
		WBPaper00042218
		WBPaper00042780
		WBPaper00043508
		WBPaper00043609
		WBPaper00043625
		WBPaper00044133
		WBPaper00044299
		WBPaper00044635
		WBPaper00045341
		WBPaper00045431
		WBPaper00045955
		WBPaper00047925
		WBPaper00047945
		WBPaper00048465
		WBPaper00049548
		WBPaper00049623
		WBPaper00051329
		WBPaper00051452
		WBPaper00051476
		WBPaper00052274
		WBPaper00052994
		WBPaper00053282
		WBPaper00054482
		WBPaper00054953
		WBPaper00055033
		WBPaper00055090
		WBPaper00056066
		WBPaper00056756
		WBPaper00056927
		WBPaper00056964
		WBPaper00057923
		WBPaper00057969
		WBPaper00058998
		WBPaper00060014
		WBPaper00061200
		WBPaper00062472
		WBPaper00062682
		WBPaper00063290
		WBPaper00063710
		WBPaper00063711
		WBPaper00064099
		WBPaper00064401
		WBPaper00064575
		WBPaper00065177
		WBPaper00065959
	Remark	[Culotti J] The unc-5 expression pattern is now published in Su et al., Development 127,585-594 (2000)
	Method	Gene