WormBase Tree Display for Gene: WBGene00006782

WBGene00006782 SMap: S_parent: Sequence: C04F5
  Identity: Version: 2
    Name: CGC_name: unc-46 Paper_evidence: WBPaper00000031
      Sequence_name: C04F5.3
      Molecular_name: C04F5.3
        C04F5.3.1
        CE27791
      Other_name: CELE_C04F5.3 Accession_evidence: NDB BX284605
      Public_name: unc-46
    DB_info: Database: AceView gene 5F576
        WormQTL gene WBGene00006782
        WormFlux gene WBGene00006782
        NDB locus_tag CELE_C04F5.3
        NCBI gene 178897
        RefSeq protein NM_071964.5
        TREEFAM TREEFAM_ID TF320931
        TrEMBL UniProtAcc Q9GZD5
        UniProt_GCRP UniProtAcc Q9GZD5
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 23 Mar 2005 14:05:09 WBPerson2970 Event: Acquires_merge: WBGene00015445
      Acquires_merge: WBGene00015445
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143011
    Allele: WBVar01499528
      WBVar01678043
      WBVar00208776
      WBVar00208777
      WBVar00208778
      WBVar00208779
      WBVar00208780
      WBVar00208781
      WBVar01499740
      WBVar01500129
      WBVar00143011
      WBVar01009861
      WBVar01009862
      WBVar01009863
      WBVar01009864
      WBVar01009865
      WBVar01009866
      WBVar01973273
      WBVar01009867
      WBVar01009868
      WBVar01009869
      WBVar01009870
      WBVar01009871
      WBVar01009872
      WBVar01009873
      WBVar01009874
      WBVar01009875
      WBVar00143095
      WBVar00600958
      WBVar01429599
      WBVar00457692
      WBVar00457693
      WBVar00457694
      WBVar01499496
      WBVar01499316
      WBVar01651264
      WBVar00143363
      WBVar01500066
    Legacy_information: e177 : shrinker contracts both dorsally and ventrally when prodded slow good forward movement poor backing; slightly small. ES3 ME2. NA3 (e300 e642).
      [C.elegansII] e177 : shrinker contracts both dorsally and ventrally when prodded, slow, good forward movement, poor backing; slightly small. ES3 ME2. OA2: e300, e642. [Brenner 1974; McIntire et al. 1993; MT]
    Strain (163)
    RNASeq_FPKM (74)
    GO_annotation: 00093030
      00093031
    Ortholog: WBGene00052707 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00030426 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00162089 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00206855 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00030424 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00222210 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g389 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g7174 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g20268 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g6840 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g6554 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g24822 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g15054 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g8059 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g2252 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g820 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00124.g5004 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-46 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g13123 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00988.g17350 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_14011 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_018482 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07296 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g3127 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50188300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g14161 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00243791 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00205618 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00257944 Strongyloides ratti From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-46 encodes a type I transmembrane protein that contains a single motif similar to the LAMP (lysosomal associated membrane glycoprotein) domain; UNC-46 and UNC-47, the C. elegans vesicular GABA transporter, are required in GABAergic neurons for loading GABA into synaptic vesicles and thus, for all GABA-mediated behaviors; a rescuing UNC-46::GFP fusion protein localizes to synaptic varicosities in the dorsal and ventral nerve cords; UNC-46 and UNC-47 are mutually required for sorting/localization to synaptic vesicles; when overexpressed, unc-47 can rescue unc-46 mutant animals. Paper_evidence: WBPaper00030788
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Jun 2008 00:00:00
      Automated_description: Located in cytoplasmic vesicle and neuromuscular junction. Expressed in GLR and neurons. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C04F5.3
    Corresponding_transcript: C04F5.3.1
    Other_sequence: Acan_isotig12346
    Associated_feature: WBsf652609
      WBsf999935
      WBsf233650
  Experimental_info: RNAi_result: WBRNAi00090126 Inferred_automatically: RNAi_primary
      WBRNAi00039641 Inferred_automatically: RNAi_primary
      WBRNAi00028449 Inferred_automatically: RNAi_primary
      WBRNAi00089966 Inferred_automatically: RNAi_primary
      WBRNAi00010134 Inferred_automatically: RNAi_primary
      WBRNAi00089726 Inferred_automatically: RNAi_primary
      WBRNAi00090284 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4785
      Expr4786
      Expr13159
      Expr15441
      Expr1021811
      Expr1143737
      Expr2017879
      Expr2036015
    Drives_construct: WBCnstr00001640
      WBCnstr00008362
      WBCnstr00008363
      WBCnstr00012243
      WBCnstr00020699
      WBCnstr00034155
    Construct_product: WBCnstr00001640
      WBCnstr00034155
      WBCnstr00038183
    Microarray_results (20)
    Expression_cluster (116)
    Interaction: WBInteraction000502940
      WBInteraction000502941
      WBInteraction000502942
      WBInteraction000518962
    WBProcess: WBbiopr:00000010
  Map_info: Map: V Position: -2.52065 Error: 0.028521
    Well_ordered
    Positive: Inside_rearr: nDf32
        yDp1
        nDf33
        sDf26
        rT1
      Positive_clone: C04F5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point (27)
      Multi_point (41)
      Pos_neg_data: 845
        2134
        3076
        3259
  Reference (65)
  Method: Gene