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WormBase Tree Display for Gene: WBGene00006793

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WBGene00006793	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	W09C5
	Identity	Version	1
		Name	CGC_name	unc-59	Person_evidence	WBPerson261
			Sequence_name	W09C5.2
			Molecular_name	W09C5.2
				W09C5.2.1
				CE20165
			Other_name	unc-88
				CELE_W09C5.2	Accession_evidence	NDB	BX284601
			Public_name	unc-59
		DB_info	Database	AceView	gene	1O225
				WormQTL	gene	WBGene00006793
				WormFlux	gene	WBGene00006793
				NDB	locus_tag	CELE_W09C5.2
				Panther	gene	CAEEL\|WormBase=WBGene00006793\|UniProtKB=Q9U334
					family	PTHR18884
				NCBI	gene	173233
				RefSeq	protein	NM_060987.6
				TrEMBL	UniProtAcc	Q9U334
				UniProt_GCRP	UniProtAcc	Q9U334
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:43	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	unc
		Reference_allele	WBVar00143070
		Allele (52)
		Legacy_information	e261 : poor backward movement forward better; thin; vulva variably abnormal often protrusive sometimes ruptured; many postembryonic lineage abnormalities resulting from variable failures in cytokinesis; gonad lineages sometimes defective; males have very abnormal tail anatomy. ES2 ME0. NA2 (e1005 (pka unc-88)).
			See unc-59.
			See also e1005, e1465, n391
			[C.elegansII] e261 : poor backward movement, forward better; thin; vulva variably abnormal, often protrusive, sometimes ruptured; many postembryonic lineage abnormalities resulting from variable failures in cytokinesis; gonad lineages sometimes defective; variable defects in neuroanatomy; males have very abnormal tail anatomy. ES2 ME0. OA3: e1005 (pka unc-88), e1465, n391. [Brenner 1974; White et al. 1982; MT]
		Strain	WBStrain00023968
			WBStrain00027078
			WBStrain00004226
			WBStrain00004137
			WBStrain00005472
			WBStrain00008449
			WBStrain00050769
		RNASeq_FPKM (74)
		GO_annotation (19)
		Ortholog	WBGene00061165	Caenorhabditis remanei	From_analysis	OMA
						TreeFam
						Inparanoid_8
			WBGene00038942	Caenorhabditis briggsae	From_analysis	OrthoMCL
						OMA
						Inparanoid_8
			WBGene00039294	Caenorhabditis briggsae	From_analysis	OrthoMCL
						WormBase-Compara
			WBGene00144771	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
			WBGene00151495	Caenorhabditis brenneri	From_analysis	Inparanoid_8
			WBGene00128281	Caenorhabditis japonica	From_analysis	Inparanoid_8
						WormBase-Compara
			WBGene00226509	Brugia malayi	From_analysis	WormBase-Compara
			CBOVI.g12176	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g5516	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g13976	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g8175	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g21228	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g22300	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g5411	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g19206	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP39.g15454	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP39.g9801	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g323	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cnig_chr_I.g2774	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold629.g9024	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00069.g3237	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_16165	Caenorhabditis latens	From_analysis	WormBase-Compara
			GCK72_001985	Caenorhabditis remanei	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g12125	Oscheius tipulae	From_analysis	WormBase-Compara
			Pan_g1986	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_10013400	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrI_pilon.g2763	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00056302	Caenorhabditis remanei	From_analysis	WormBase-Compara
			WBGene00238801	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00115601	Pristionchus pacificus	From_analysis	WormBase-Compara
			WBGene00260502	Strongyloides ratti	From_analysis	WormBase-Compara
			WBGene00293113	Trichuris muris	From_analysis	WormBase-Compara
			SGD:S000004306	Saccharomyces cerevisiae	From_analysis	EnsEMBL-Compara
						Hieranoid
						OMA
						Panther
			FB:FBgn0013726	Drosophila melanogaster	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-030131-911	Danio rerio	From_analysis	Inparanoid
						OMA
						OrthoInspector
						SonicParanoid
			ZFIN:ZDB-GENE-030131-7868	Danio rerio	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			ZFIN:ZDB-GENE-040426-1008	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			ZFIN:ZDB-GENE-040808-43	Danio rerio	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			ZFIN:ZDB-GENE-051120-87	Danio rerio	From_analysis	Inparanoid
						OrthoInspector
						SonicParanoid
			ZFIN:ZDB-GENE-061103-265	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-030131-37	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-071127-1	Danio rerio	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			HGNC:1717	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:7729	Homo sapiens	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			HGNC:9164	Homo sapiens	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			HGNC:9165	Homo sapiens	From_analysis	Inparanoid
						OMA
						OrthoInspector
						SonicParanoid
			MGI:97298	Mus musculus	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			MGI:1195461	Mus musculus	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			MGI:1270156	Mus musculus	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			MGI:1335094	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:620469	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:621763	Rattus norvegicus	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			RGD:620056	Rattus norvegicus	From_analysis	OMA
						OrthoInspector
						SonicParanoid
			RGD:1308781	Rattus norvegicus	From_analysis	OMA
						OrthoInspector
						SonicParanoid
		Paralog	WBGene00015956	Caenorhabditis elegans	From_analysis	Panther
			WBGene00006795	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	unc-59, by alternative splicing, encodes two septin isoforms required (like the septins UNC-61A/B) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-59 and UNC-61A/B are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-59 and UNC-61A/B depend on each other for localization to the cytokinetic furrow.	Paper_evidence	WBPaper00000496
						WBPaper00004453
						WBPaper00006087
					Curator_confirmed	WBPerson567
					Date_last_updated	01 Feb 2006 00:00:00
			Automated_description	Predicted to enable GTPase activity and molecular adaptor activity. Involved in egg-laying behavior; locomotion; and post-embryonic development. Located in cleavage furrow and midbody. Expressed in several structures, including buccal cavity; distal tip cell; germ line; pharynx; and sperm. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Is an ortholog of human SEPTIN7 (septin 7).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:12217	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:9165)
			DOID:14330	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:9165)
	Molecular_info	Corresponding_CDS	W09C5.2
		Corresponding_transcript	W09C5.2.1
		Other_sequence (38)
		Associated_feature (15)
	Experimental_info	RNAi_result (38)
		Expr_pattern	Expr2318
			Expr2691
			Expr3284
			Expr14682
			Expr1015124
			Expr1032863
			Expr1158568
			Expr2017891
			Expr2036027
		Drives_construct	WBCnstr00010902
		Construct_product	WBCnstr00005646
			WBCnstr00010902
		Antibody	WBAntibody00000329
			WBAntibody00000930
		Microarray_results (20)
		Expression_cluster (156)
		Interaction (77)
	Map_info	Map	I	Position	21.6174	Error	0.007359
		Well_ordered
		Positive	Positive_clone	W09C5	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	2_point	22
				24
				30
				33
			Multi_point (14)
			Pos_neg_data (14)
		Landmark_gene
	Reference (49)
	Remark	Sequence connection from [Nguyen TQ, White JG]
	Method	Gene