WormBase Tree Display for Gene: WBGene00006796
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| WBGene00006796 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T28F12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-62 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T28F12.2 | ||||||||
| Molecular_name (34) | |||||||||
| Other_name | let-328 | ||||||||
| nob-5 | |||||||||
| ceh-25 | |||||||||
| CELE_T28F12.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-62 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143365 | ||||||||
| Allele (240) | |||||||||
| Possibly_affected_by | WBVar02153039 | ||||||||
| Legacy_information | e644 : slightly slow irregular sometimes rippling movement especially in reverse; slightly dumpy; variable abnormalities in VD and DD commissures; male tail abnormal bursa small fan reduced rays variably absent. ES2 ME0. NA1. | ||||||||
| See also s472 | |||||||||
| [C.elegansII] e644 : slightly slow, irregular, sometimes rippling movement, especially in reverse; slightly dumpy; variable abnormalities in VD and DD commissures; male tail abnormal, bursa small, fan reduced, rays variably absent. 19% of embryos Nob. ES2 ME0. OA2: s472spo(pka let-328, lethal, probable null), ct344 (pka nob-5, partial maternal effect Nob, disorganized posterior). [Brenner 1974; BC; BW] | |||||||||
| [Burglin T] NMK. Encodes novel atypical homeoprotein. | |||||||||
| [Burglin T] TALE/MEIS class homeobox gene. | |||||||||
| Strain (11) | |||||||||
| Component_of_genotype | WBGenotype00000160 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (40) | |||||||||
| Ortholog (52) | |||||||||
| Paralog | WBGene00000443 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000461 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00017690 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | unc-62 encodes a Meis-class homeodomain protein required for posterior embryonic morphogenesis, male tail morphogenesis, commissure formation by VD and DD motor neurons, vulval morphogenesis, and normal locomotion; UNC-62 is orthologous to Drosophila HOMOTHORAX; both maternal-effect unc-62 alleles and the zygotic lethal unc-62(s472) allele phenotypically resemble mutations of the caudal ortholog pal-1; RNAi of the Pbc-class ceh-20 and ceh-40 homeodomain genes strongly enhances the hypomorphic unc-62(e644) allele to give either a strong loss-of-function or null-like phenotype, while overexpression of ceh-20 enhances the lethality of some unc-62 alleles. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00000608 | |||||||||
| WBPaper00005629 | |||||||||
| WBPaper00018977 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; muscle cell differentiation; and regulation of gene expression. Acts upstream of or within lipid homeostasis. Located in nucleus. Part of chromatin. Expressed in several structures, including body wall musculature; neurons; reproductive system; ventral nerve cord; and vulval precursor cell. Used to study leukemia and restless legs syndrome. Human ortholog(s) of this gene implicated in several diseases, including cleft palate; cleft palate, cardiac defects, and intellectual disabillity; and open-angle glaucoma. Is an ortholog of human MEIS1 (Meis homeobox 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1240 | Homo sapiens | Paper_evidence | WBPaper00032952 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 13 Jun 2018 00:00:00 | ||||||||
| DOID:0050425 | Homo sapiens | Paper_evidence | WBPaper00039832 | ||||||
| WBPaper00060285 | |||||||||
| WBPaper00061684 | |||||||||
| Accession_evidence | OMIM | 612853 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Jan 2024 00:00:00 | ||||||||
| Potential_model | DOID:8927 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7001) | |||||
| DOID:114 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7000) | ||||||
| DOID:0050567 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7001) | ||||||
| DOID:674 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7001) | ||||||
| DOID:0111697 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7001) | ||||||
| DOID:1067 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7001) | ||||||
| Models_disease_in_annotation | WBDOannot00000329 | ||||||||
| WBDOannot00001201 | |||||||||
| WBDOannot00001436 | |||||||||
| Models_disease_asserted | WBDOannot00000545 | ||||||||
| WBDOannot00000564 | |||||||||
| Molecular_info | Corresponding_CDS | T28F12.2a | |||||||
| T28F12.2b | |||||||||
| T28F12.2c | |||||||||
| T28F12.2d | |||||||||
| T28F12.2e | |||||||||
| T28F12.2f | |||||||||
| T28F12.2g | |||||||||
| T28F12.2h | |||||||||
| Corresponding_transcript (18) | |||||||||
| Other_sequence (61) | |||||||||
| Associated_feature (46) | |||||||||
| Gene_product_binds (8419) | |||||||||
| Transcription_factor | WBTranscriptionFactor000342 | ||||||||
| Experimental_info | RNAi_result (81) | ||||||||
| Expr_pattern (34) | |||||||||
| Drives_construct (30) | |||||||||
| Construct_product (11) | |||||||||
| Microarray_results (60) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction (263) | |||||||||
| Anatomy_function | WBbtf0426 | ||||||||
| Product_binds_matrix | WBPmat00005551 | ||||||||
| WBPmat00005552 | |||||||||
| WBPmat00005557 | |||||||||
| Map_info | Map | V | Position | -5.18378 | Error | 0.036882 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf32 | |||||||
| sDf26 | |||||||||
| sDf27 | |||||||||
| Positive_clone | T28F12 | Author_evidence | Weaver DC, | ||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 125 | |||||||
| 1768 | |||||||||
| 3572 | |||||||||
| 4449 | |||||||||
| 7023 | |||||||||
| 7024 | |||||||||
| Multi_point | 143 | ||||||||
| 481 | |||||||||
| 1524 | |||||||||
| 3277 | |||||||||
| 3574 | |||||||||
| 5427 | |||||||||
| 5652 | |||||||||
| Pos_neg_data | 846 | ||||||||
| 2870 | |||||||||
| 2871 | |||||||||
| 2872 | |||||||||
| 1790 | |||||||||
| 1796 | |||||||||
| 1807 | |||||||||
| 3620 | |||||||||
| Landmark_gene | |||||||||
| Reference (96) | |||||||||
| Remark | Sequence connection from [Burglin T] | ||||||||
| old_name ceh-25 becomes new_name unc-62 from [Burglin T]. | |||||||||
| Method | Gene |
