WormBase Tree Display for Gene: WBGene00006801

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WBGene00006801	SMap	S_parent	Sequence	CHROMOSOME_V
	Identity	Version	2
		Name	CGC_name	unc-68	Person_evidence	WBPerson261
			Sequence_name	K11C4.5
			Molecular_name (48)
			Other_name	ryr-1
				kra-1
				CELE_K11C4.5	Accession_evidence	NDB	BX284605
			Public_name	unc-68
		DB_info	Database (11)
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:43	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	07 Nov 2007 17:12:59	WBPerson2970	Event	Acquires_merge	WBGene00021962
			Acquires_merge	WBGene00021962
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	unc
		Reference_allele	WBVar00143286
		Allele	WBVar00088236	Inferred_automatically	From strain object: HK30
			WBVar00088237	Inferred_automatically	From strain object: HK53
			WBVar00241452	Inferred_automatically	From strain object: NM1081
					From strain object: PS3818
			WBVar00241453	Inferred_automatically	From strain object: TR2170
			WBVar02153075	Inferred_automatically	From strain object: UL4239
			WBVar02153076	Inferred_automatically	From strain object: UL4285
			WBVar00275209
			WBVar00143611
			WBVar00143321
			WBVar00296585
			WBVar00296595
			WBVar00296584
			WBVar00296590
			WBVar00241710
			WBVar00143612
			WBVar00143420
			WBVar00143437
			WBVar00275218
			WBVar00144733
			WBVar00296592
			WBVar00296591
			WBVar00143610
			WBVar00241461
			WBVar02158032
			WBVar02158181
			WBVar02158182
			WBVar02158183
			WBVar02158197
			WBVar02158203
			WBVar02158196
			WBVar02158199
			WBVar02158200
			WBVar02158202
			WBVar02158650
			WBVar01021548
			WBVar01021549
			WBVar01021550
			WBVar01741014
			WBVar01021551
			WBVar01021552
			WBVar01741015
			WBVar01021553
			WBVar01741016
			WBVar01741017
			WBVar01021554
			WBVar01021555
			WBVar01021556
			WBVar01021557
			WBVar01021558
			WBVar01021559
			WBVar01021560
			WBVar01021561
			WBVar01500265
			WBVar01021562
			WBVar01500266
			WBVar01021563
			WBVar01021564
			WBVar01021565
			WBVar01021566
			WBVar01021567
			WBVar00316821
			WBVar01021568
			WBVar00316822
			WBVar01021569
			WBVar01021570
			WBVar02152367
			WBVar01021571
			WBVar01021572
			WBVar01021573
			WBVar01021574
			WBVar00027176
			WBVar01021575
			WBVar01021576
			WBVar01021577
			WBVar00027181
			WBVar01021578
			WBVar01021579
			WBVar01021580
			WBVar01021581
			WBVar00027186
			WBVar01021582
			WBVar01021583
			WBVar01021584
			WBVar01021585
			WBVar01021586
			WBVar01021587
			WBVar01021588
			WBVar01499740
			WBVar01021589
			WBVar01021590
			WBVar00241454
			WBVar01021591
			WBVar01825823
			WBVar01021592
			WBVar01021593
			WBVar01021594
			WBVar01021595
			WBVar01021596
			WBVar01021597
			WBVar01973961
			WBVar01021598
			WBVar01973962
			WBVar01021599
			WBVar01021600
			WBVar01021601
			WBVar01021602
			WBVar01021603
			WBVar01021420
			WBVar01021604
			WBVar01021421
			WBVar01021605
			WBVar01021422
			WBVar01021606
			WBVar01021607
			WBVar01021423
			WBVar01021608
			WBVar01021424
			WBVar01500129
			WBVar01021425
			WBVar01021609
			WBVar01021426
			WBVar01021610
			WBVar01021427
			WBVar01021611
			WBVar01021428
			WBVar01021429
			WBVar01021430
			WBVar01021431
			WBVar01021432
			WBVar01021433
			WBVar00461481
			WBVar01021434
			WBVar00461482
			WBVar01021435
			WBVar00461483
			WBVar01021436
			WBVar00461484
			WBVar00461485
			WBVar01021437
			WBVar00461486
			WBVar01021438
			WBVar00461487
			WBVar01021439
			WBVar00461488
			WBVar01021440
			WBVar01021441
			WBVar00461489
			WBVar01021442
			WBVar00461490
			WBVar01021443
			WBVar00461491
			WBVar01021444
			WBVar00461492
			WBVar01021445
			WBVar00461493
			WBVar00461494
			WBVar01021446
			WBVar00461495
			WBVar01021447
			WBVar00461496
			WBVar01021448
			WBVar01021449
			WBVar00461497
			WBVar01021450
			WBVar00461498
			WBVar00461499
			WBVar01021451
			WBVar00461500
			WBVar01021452
			WBVar00461501
			WBVar01021453
			WBVar00461502
			WBVar01021454
			WBVar01021455
			WBVar00461503
			WBVar00461504
			WBVar01499056
			WBVar01021456
			WBVar00461505
			WBVar01021457
			WBVar02136557
			WBVar01021458
			WBVar00461506
			WBVar02136558
			WBVar00461507
			WBVar01021459
			WBVar02136559
			WBVar01021460
			WBVar02136560
			WBVar00461508
			WBVar02136561
			WBVar00461509
			WBVar01021461
			WBVar00461510
			WBVar01021462
			WBVar00461511
			WBVar01021463
			WBVar00461512
			WBVar01021464
			WBVar00600935
			WBVar01021465
			WBVar00461513
			WBVar01021466
			WBVar00461514
			WBVar01021467
			WBVar00461515
			WBVar01021468
			WBVar00461516
			WBVar00461517
			WBVar01021469
			WBVar01021470
			WBVar00461518
			WBVar00461519
			WBVar01021471
			WBVar00461520
			WBVar01021472
			WBVar00461521
			WBVar01021473
			WBVar01021474
			WBVar00461522
			WBVar01021475
			WBVar00461523
			WBVar01021476
			WBVar00461524
			WBVar00461525
			WBVar01021477
			WBVar00461526
			WBVar01021478
			WBVar00461527
			WBVar01021479
			WBVar02121266
			WBVar00461528
			WBVar01021480
			WBVar00461529
			WBVar01021481
			WBVar00461530
			WBVar01021482
			WBVar00461531
			WBVar01021483
			WBVar01021484
			WBVar01021485
			WBVar01021486
			WBVar01021487
			WBVar01021488
			WBVar01021489
			WBVar01021490
			WBVar01661200
			WBVar01021491
			WBVar01021492
			WBVar01021493
			WBVar01021494
			WBVar01021495
			WBVar01021496
			WBVar02080244
			WBVar01021497
			WBVar01021498
			WBVar01021499
			WBVar00210926
			WBVar00210927
			WBVar01021500
			WBVar00210928
			WBVar01021501
			WBVar00210929
			WBVar01021502
			WBVar01021503
			WBVar00210931
			WBVar01021504
			WBVar00210932
			WBVar00210933
			WBVar01021505
			WBVar01021506
			WBVar00210934
			WBVar00210935
			WBVar01021507
			WBVar00210936
			WBVar02124239
			WBVar01021508
			WBVar01021509
			WBVar00210937
			WBVar01021510
			WBVar00210939
			WBVar01021511
			WBVar02150443
			WBVar00210940
			WBVar00210941
			WBVar01021512
			WBVar01021513
			WBVar00210942
			WBVar00598908
			WBVar00210943
			WBVar01808428
			WBVar01021514
			WBVar00210944
			WBVar01021515
			WBVar00210945
			WBVar01021516
			WBVar00272154
			WBVar00272157
			WBVar00210946
			WBVar01021517
			WBVar01021518
			WBVar01021519
			WBVar01021520
			WBVar01021521
			WBVar01021522
			WBVar01021523
			WBVar01021524
			WBVar00298868
			WBVar01021525
			WBVar00143286
			WBVar01021526
			WBVar01021527
			WBVar01021528
			WBVar01499496
			WBVar01021529
			WBVar01021530
			WBVar01021531
			WBVar01499316
			WBVar01021532
			WBVar01842345
			WBVar02043499
			WBVar02015368
			WBVar01021533
			WBVar01021534
			WBVar01021535
			WBVar02060217
			WBVar01588536
			WBVar00266262
			WBVar01021536
			WBVar01588537
			WBVar01021537
			WBVar00601471
			WBVar01588538
			WBVar01021538
			WBVar01588539
			WBVar01021539
			WBVar01021540
			WBVar01460394
			WBVar01588540
			WBVar01021541
			WBVar01460395
			WBVar01021542
			WBVar01460397
			WBVar01021543
			WBVar01460398
			WBVar01021544
			WBVar01460399
			WBVar01021545
			WBVar01500066
			WBVar01021546
			WBVar01021547
		Legacy_information	See also e2313
			[Kagawa H] pka ryr-1, for ryanodine receptor. 46 exons, encodes 5071 aa predicted protein. e540 (Unc-68) is intron 21 splice acceptor mutation, probable null. Weak allele kh30 (pka kra-1) exhibits ketamine-dependent convulsions followed by paralysis, mutation is S1444N change at putative PKC phosphorylation site.
			[C.elegansII] e540 : weak kinker, slow, thin; slight shrinker; head region but not body resistant to 1 mM levamisole, ouabain. ES3. ME2. OA>15: x14, x24, e932, e2313,s92spo, r1162 (presumed null, deletes all TM domains) etc.(all resemble e540). Cloned: 30 kb gene, 43 exons, encodes 4902 aa ryanodine receptor (43% identity to mammalian cardiac RYR). [Brenner 1974; Lewis et al. 1980; HK; TR]
			[C.elegansII] kh30 : semidominant convulsive behavior in 30mM ketamine or other NMDA antagonists; recessive cs Unc; variable motility; weakly resistant to cholinergic agonists, ouabain;normal muscle morphology. [HK]
		Complementation_data	[Kagawa H] fails to complement kh30 (pka kra-1)
		Strain (21)
		RNASeq_FPKM (74)
		GO_annotation (28)
		Ortholog (67)
		Paralog	WBGene00002173	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	unc-68 encodes a ryanodine receptor ortholog that is expressed in body-wall muscle cells and is required for normal body tension and locomotion; unc-68 mutants are flaccid, sluggish, and resistant to ryanodine, but have normal muscle ultrastructure; UNC-68 is dispensable for excitation-contraction coupling itself, but may amplify its calcium signals; the unc-68/kra-1(kh30) mutation is an S1444N substitution at a putative protein kinase C phosphorylation site; UNC-68 reduced unc-103(sy557)-induced spicule protraction by one half; unc-68 is orthologous to the human genes RYR1 (OMIM:180901, mutated in malignant hyperthermia and central core disease), RYR2 (OMIM:180902, mutated in stress-induced polymorphic ventricular tachycardia), and RYR3 (OMIM:180903).	Paper_evidence	WBPaper00002536
						WBPaper00002749
						WBPaper00005799
						WBPaper00006125
					Curator_confirmed	WBPerson1823
						WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Predicted to enable calcium ion binding activity and ryanodine-sensitive calcium-release channel activity. Involved in locomotion; positive regulation of programmed cell death; and protein localization to organelle. Located in I band and sarcoplasmic reticulum. Expressed in body wall musculature; intestine; neurons; and non-striated muscle. Used to study congenital myopathy 1A and malignant hyperthermia. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; intracranial vasospasm; and muscle tissue disease (multiple). Is an ortholog of human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Experimental_model	DOID:3529	Homo sapiens	Paper_evidence	WBPaper00059411
					Curator_confirmed	WBPerson324
					Date_last_updated	08 Jun 2021 00:00:00
			DOID:8545	Homo sapiens	Paper_evidence	WBPaper00059411
					Curator_confirmed	WBPerson324
					Date_last_updated	08 Jun 2021 00:00:00
		Potential_model (12)
	Modifies_disease	DOID:11723
	Modifies_disease_in_annotation	WBDOannot00000746
	Models_disease_asserted (14)
	Molecular_info	Corresponding_CDS (16)
		Corresponding_CDS_history	K11C4.5:wp166
			K11C4.5:wp184
			K11C4.5a:wp261
			K11C4.5b:wp236
			K11C4.5b:wp261
			K11C4.5c:wp261
			K11C4.5d:wp261
		Corresponding_transcript (16)
		Other_sequence (63)
		Associated_feature (24)
	Experimental_info	RNAi_result (20)
		Expr_pattern (12)
		Drives_construct	WBCnstr00006689
			WBCnstr00010174
			WBCnstr00010354
			WBCnstr00010749
			WBCnstr00015983
			WBCnstr00015984
			WBCnstr00039937
			WBCnstr00039938
		Construct_product	WBCnstr00000351
			WBCnstr00000352
			WBCnstr00006689
			WBCnstr00010354
			WBCnstr00010749
			WBCnstr00014791
			WBCnstr00016961
			WBCnstr00017064
		Antibody (12)
		Microarray_results (34)
		Expression_cluster (208)
		Interaction (56)
	Map_info	Map	V	Position	0.477486	Error	0.002969
		Well_ordered
		Positive	Inside_rearr	sDf20
			Positive_clone	K11C4	Inferred_automatically	From sequence, transcript, pseudogene data
				M04C11
		Negative	Outside_rearr	nDf31
			Negative_clone	M04C11
		Mapping_data	2_point	310
				2841
				3136
				4524
			Multi_point (17)
			Pos_neg_data (16)
		Landmark_gene
	Reference (150)
	Remark	results of mutation site, phenotype, rescue appear in J. Mol. Biol. 267, 849-864. 1997 Sakube, Y., Ando, H. & Kagawa H.
	Method	Gene