WormBase Tree Display for Gene: WBGene00006809
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| WBGene00006809 | SMap | S_parent | Sequence | C11D2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-77 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C11D2.6 | ||||||||
| Molecular_name (48) | |||||||||
| Other_name | nca-1 | Paper_evidence | WBPaper00031592 | ||||||
| Person_evidence | WBPerson604 | ||||||||
| CELE_C11D2.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | unc-77 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006809 | |||||
| WormFlux | gene | WBGene00006809 | |||||||
| NDB | locus_tag | CELE_C11D2.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006809|UniProtKB=V6CKM5 | |||||||
| family | PTHR46141 | ||||||||
| NCBI | gene | 177379 | |||||||
| RefSeq | protein (16) | ||||||||
| TREEFAM | TREEFAM_ID | TF312843 | |||||||
| TrEMBL | UniProtAcc (16) | ||||||||
| UniProt_GCRP | UniProtAcc | V6CKM5 | |||||||
| OMIM | gene | 611549 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 03 Dec 2009 11:55:50 | WBPerson2970 | Event | Acquires_merge | WBGene00003557 | ||||
| Acquires_merge | WBGene00003557 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143348 | ||||||||
| Allele (298) | |||||||||
| Legacy_information | e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. | ||||||||
| [C.elegansII] e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. [Brenner 1974] | |||||||||
| Strain | WBStrain00035028 | ||||||||
| WBStrain00035029 | |||||||||
| WBStrain00035482 | |||||||||
| WBStrain00040855 | |||||||||
| WBStrain00040862 | |||||||||
| WBStrain00040863 | |||||||||
| WBStrain00040864 | |||||||||
| WBStrain00040865 | |||||||||
| WBStrain00006352 | |||||||||
| Component_of_genotype | WBGenotype00000089 | ||||||||
| WBGenotype00000090 | |||||||||
| WBGenotype00000091 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00003558 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000367 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001187 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006742 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008911 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-77 encodes, along with nca-2, one of two C. elegans alpha-1-like subunits of a voltage-insensitive cation leak channel related to Drosophila narrow abdomen and the vertebrate Vgcnl1/NALCN proteins; unc-77 functions redundantly with nca-2 to transmit depolarization signals from neuronal cell bodies to axons, thus regulating presynaptic activation; unc-77 and nca-2 are also required for normal locomotion and the response to specific volatile anesthetics; in regulating synaptic activity, unc-77 appears to function in the same pathway as unc-79 and unc-80, which encode novel conserved proteins that reciprocally regulate UNC-77 expression; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-77::gfp reporter fusion is expressed in many sensory and all motoneurons; in the dorsal and ventral nerve cords, UNC-77 localizes to specific axonal regions, but not to synapses. | Paper_evidence | WBPaper00030757 | |||||
| WBPaper00031000 | |||||||||
| WBPaper00031592 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Jun 2010 00:00:00 | ||||||||
| Automated_description | Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Expressed in cholinergic neurons; nerve ring; pharyngeal neurons; and tail ganglion. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0081048 | Homo sapiens | Paper_evidence | WBPaper00046648 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Feb 2022 00:00:00 | ||||||||
| Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19082) | |||||
| DOID:0081048 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19082) | ||||||
| Models_disease_asserted | WBDOannot00001101 | ||||||||
| WBDOannot00001105 | |||||||||
| Molecular_info | Corresponding_CDS (16) | ||||||||
| Corresponding_CDS_history | C11D2.6a:wp239 | ||||||||
| C11D2.6b:wp239 | |||||||||
| C11D2.6c:wp239 | |||||||||
| Corresponding_transcript (16) | |||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf651837 | ||||||||
| WBsf996705 | |||||||||
| WBsf996706 | |||||||||
| WBsf996707 | |||||||||
| WBsf996708 | |||||||||
| WBsf996709 | |||||||||
| WBsf1017492 | |||||||||
| WBsf1017493 | |||||||||
| WBsf230141 | |||||||||
| WBsf230142 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Chronogram197 | ||||||||
| Expr4860 | |||||||||
| Expr5240 | |||||||||
| Expr8058 | |||||||||
| Expr8060 | |||||||||
| Expr8194 | |||||||||
| Expr8324 | |||||||||
| Expr1144413 | |||||||||
| Expr2017906 | |||||||||
| Expr2036042 | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00017151 | ||||||||
| WBCnstr00021676 | |||||||||
| WBCnstr00021677 | |||||||||
| WBCnstr00021678 | |||||||||
| WBCnstr00021679 | |||||||||
| WBCnstr00021680 | |||||||||
| WBCnstr00021681 | |||||||||
| WBCnstr00037886 | |||||||||
| Antibody | WBAntibody00001260 | ||||||||
| WBAntibody00001384 | |||||||||
| Microarray_results (48) | |||||||||
| Expression_cluster (190) | |||||||||
| Interaction (21) | |||||||||
| Map_info | Map | IV | Position | 3.08555 | |||||
| Positive | Positive_clone | C11D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 323 | |||||||
| Multi_point | 1422 | ||||||||
| 4509 | |||||||||
| Reference (42) | |||||||||
| Method | Gene |
