WormBase Tree Display for Gene: WBGene00006812
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WBGene00006812 | SMap | S_parent | Sequence | F25C8 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | unc | |||||
Reference_allele | WBVar00143879 | |||||
Allele (316) | ||||||
Legacy_information | e1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069). | |||||
See also e1069, e1272 | ||||||
[C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW] | ||||||
Strain | WBStrain00032777 | |||||
WBStrain00040621 | ||||||
WBStrain00004238 | ||||||
WBStrain00004286 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (15) | ||||||
Ortholog (35) | ||||||
Structured_description | Concise_description | unc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons. | Paper_evidence | WBPaper00001281 | ||
WBPaper00031000 | ||||||
WBPaper00031592 | ||||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 22 Jun 2010 00:00:00 | |||||
Automated_description | Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:26582) | |
Molecular_info | Corresponding_CDS | F25C8.3a | ||||
F25C8.3b | ||||||
F25C8.3c | ||||||
F25C8.3d | ||||||
F25C8.3e | ||||||
Corresponding_CDS_history | F25C8.3:wp87 | |||||
F25C8.3:wp109 | ||||||
F25C8.3a:wp182 | ||||||
Corresponding_transcript | F25C8.3a.1 | |||||
F25C8.3b.1 | ||||||
F25C8.3c.1 | ||||||
F25C8.3d.1 | ||||||
F25C8.3e.1 | ||||||
Other_sequence (25) | ||||||
Associated_feature | WBsf647771 | |||||
WBsf662284 | ||||||
WBsf662285 | ||||||
WBsf662286 | ||||||
WBsf1003660 | ||||||
WBsf1003661 | ||||||
WBsf1003662 | ||||||
WBsf1022024 | ||||||
WBsf1022025 | ||||||
WBsf1022026 | ||||||
Experimental_info | RNAi_result (12) | |||||
Expr_pattern | Expr4994 | |||||
Expr8059 | ||||||
Expr8061 | ||||||
Expr16166 | ||||||
Expr1026757 | ||||||
Expr1032878 | ||||||
Expr1149400 | ||||||
Expr2017910 | ||||||
Expr2036046 | ||||||
Drives_construct | WBCnstr00000610 | |||||
WBCnstr00001622 | ||||||
WBCnstr00013085 | ||||||
WBCnstr00042790 | ||||||
Construct_product | WBCnstr00000610 | |||||
Microarray_results (26) | ||||||
Expression_cluster (205) | ||||||
Interaction (41) | ||||||
Map_info (3) | ||||||
Reference (46) | ||||||
Method | Gene |