WormBase Tree Display for Gene: WBGene00006814
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WBGene00006814 | SMap | S_parent | Sequence | B0496 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143842 | ||||||
Allele (253) | |||||||
Possibly_affected_by | WBVar02153065 | ||||||
Legacy_information | e1220 : slow good movement abnormal reduced muscle birefringence abnormal body muscle ultrastruture with enlarged thick filaments etc. ES2 ME2. NA9 (e1323 r194 etc. : all resemble e1220). | ||||||
See also e1220, e1323 | |||||||
[C.elegansII] e1220 : slow, good movement, abnormal reduced muscle birefringence; abnormal body muscle ultrastructure with enlarged thick filaments; weaker pharyngeal muscle abnormalities. ES2 ME2. OA>5: e1323, r194, st1323 etc. (all resemble e1220). [Waterston and Brenner 1980; RW] | |||||||
Strain | WBStrain00033499 | ||||||
WBStrain00033522 | |||||||
WBStrain00033523 | |||||||
WBStrain00037392 | |||||||
WBStrain00004275 | |||||||
WBStrain00004300 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (45) | |||||||
Paralog (19) | |||||||
Structured_description | Concise_description | unc-82 encodes a serine/threonine kinase related to the human ARK5/SNARK (NUAK1/NUAK2) and the PAR-1 and SNF1/AMP-Activated kinase (AMPK) protein kinase families; during development, UNC-82 activity is required for proper organization of internal (membrane-distal) proteins of myosin thick filaments and M-lines in conjunction with embryonic elongation; an UNC-82::GFP reporter fusion is expressed in muscle cells and is associated with M lines; UNC-82::GFP expression is also seen in the pharynx. | Paper_evidence | WBPaper00035423 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 04 Jan 2011 00:00:00 | ||||||
Automated_description | A structural constituent of muscle. Involved in striated muscle myosin thick filament assembly and striated muscle paramyosin thick filament assembly. Located in M band. Expressed in body wall musculature. Human ortholog(s) of this gene implicated in anencephaly. Is an ortholog of human NUAK1 (NUAK family kinase 1) and NUAK2 (NUAK family kinase 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0060668 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29558) | ||
DOID:13223 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14311) | ||||
Molecular_info | Corresponding_CDS | B0496.3a | |||||
B0496.3b | |||||||
B0496.3c | |||||||
B0496.3d | |||||||
B0496.3e | |||||||
B0496.3f | |||||||
B0496.3g | |||||||
B0496.3h | |||||||
B0496.3i | |||||||
Corresponding_CDS_history | B0496.3a:wp187 | ||||||
B0496.3a:wp209 | |||||||
B0496.3b:wp187 | |||||||
B0496.3b:wp209 | |||||||
B0496.3c:wp209 | |||||||
Corresponding_transcript (11) | |||||||
Other_sequence (35) | |||||||
Associated_feature (30) | |||||||
Gene_product_binds | WBsf919647 | ||||||
Experimental_info | RNAi_result (25) | ||||||
Expr_pattern | Expr8836 | ||||||
Expr1015480 | |||||||
Expr1032879 | |||||||
Expr1143277 | |||||||
Expr2017911 | |||||||
Expr2036047 | |||||||
Drives_construct | WBCnstr00007842 | ||||||
WBCnstr00013549 | |||||||
WBCnstr00034140 | |||||||
Construct_product | WBCnstr00007842 | ||||||
WBCnstr00013549 | |||||||
WBCnstr00034140 | |||||||
WBCnstr00041813 | |||||||
WBCnstr00041814 | |||||||
Microarray_results (53) | |||||||
Expression_cluster (211) | |||||||
Interaction (55) | |||||||
Map_info | Map | IV | Position | 3.33492 | Error | 0.000317 | |
Positive | Positive_clone | B0496 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 108 | |||||
Multi_point | 286 | ||||||
912 | |||||||
913 | |||||||
914 | |||||||
915 | |||||||
Pos_neg_data | 3262 | ||||||
8144 | |||||||
8145 | |||||||
Reference (40) | |||||||
Method | Gene |