| WBGene00006830 | SMap | S_parent | Sequence | CHROMOSOME_III |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | unc-103 | Person_evidence | WBPerson261 |
| | | Sequence_name | C30D11.1 |
| | | Molecular_name (57) |
| | | Other_name | CELE_C30D11.1 | Accession_evidence | NDB | BX284603 |
| | | Public_name | unc-103 |
| | DB_info | Database | WormQTL | gene | WBGene00006830 |
| | | | WormFlux | gene | WBGene00006830 |
| | | | NDB | locus_tag | CELE_C30D11.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006830|UniProtKB=G5EFJ9 |
| | | | | family | PTHR10217 |
| | | | NCBI | gene | 175527 |
| | | | RefSeq | protein (19) |
| | | | SwissProt | UniProtAcc | G5EFJ9 |
| | | | TrEMBL | UniProtAcc | A0A8D7ZGL5 |
| | | | | | A0A8D7ZF36 |
| | | | | | A0A8D7ZGA2 |
| | | | | | A0A8D7ZEX1 |
| | | | | | A0A8D7ZEY3 |
| | | | | | A0A8D7ZEU0 |
| | | | | | A0A8D8EJ82 |
| | | | | | A0A8D7ZEP4 |
| | | | | | A0A8D7ZGB1 |
| | | | UniProt_GCRP | UniProtAcc | G5EFJ9 |
| | | | OMIM | gene | 152427 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 20 Jun 2007 16:44:06 | WBPerson1983 | Event | Acquires_merge | WBGene00007815 |
| | | Acquires_merge | WBGene00007815 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Allele (416) |
| | Legacy_information | Class 3 allele e1597sd : severe kinker little movement slight Egl; e1597/+ somewhat less severe kinker. ES3 ME0. NA2 (n500). Class 1 (loss-of-function) alleles : intragenic revertants of e1596 e.g. e1597n1212 wildtype phenotype. |
| | | See also e1597, n500, n1211, n1212, n1213, n1214, n1215 |
| | | [Reiner D]] Mac-d (Muscle ACtivation-Defective) |
| | | [C.elegansII] e1597sd : homozygote severe kinker, little movement; slight Egl; e1597/+ somewhat less severe kinker. Muscle activation defective(flaccid, long). Neomorphic (gf) allele.ES3 ME0. OA1 (gf): n500. Also intragenic revertants: e1597n1212spo(wildtype, probable null), e1597n1213, n500n1211 etc. OA5 (ird). [Park and Horvitz 1986a; JT; MT] |
| | Strain (13) |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog (44) |
| | Paralog | WBGene00001171 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00000487 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00000562 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00000563 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00006525 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00006526 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00022295 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | unc-103 encodes an ether-a-go-go-related (ERG) K+ channel homolog, orthologous to human KCNH6 (OMIM:608168); UNC-103 regulates muscle activation in motility, egg-laying and male spicule protraction; UNC-103 is expressed highly in many neurons; gain-of-function unc-103 alleles can be uncoordinated, while loss-of-function alleles have a more subtle defect in copulatory spicule protraction. | Paper_evidence | WBPaper00000914 |
| | | | | | WBPaper00002305 |
| | | | | | WBPaper00005799 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 09 Feb 2011 00:00:00 |
| | | Automated_description | Predicted to enable inward rectifier potassium channel activity. Involved in mating behavior and regulation of muscle contraction. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in body wall musculature; neurons; non-striated muscle; and in male. Used to study long QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome 2 and short QT syndrome. Is an ortholog of human KCNH2 (potassium voltage-gated channel subfamily H member 2) and KCNH7 (potassium voltage-gated channel subfamily H member 7). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:2843 |
| | Potential_model | DOID:0050793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6251) |
| | | DOID:0110645 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6251) |
| | | DOID:2843 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6251) |
| Models_disease_asserted | WBDOannot00000527 |
| Molecular_info | Corresponding_CDS (19) |
| | Corresponding_CDS_history | C30D11.1:wp52 |
| | Corresponding_transcript (19) |
| | Other_sequence (14) |
| | Associated_feature (50) |
| Experimental_info | RNAi_result (21) |
| | Expr_pattern | Expr2455 |
| | | Expr3095 |
| | | Expr3815 |
| | | Expr4896 |
| | | Expr10803 |
| | | Expr1012330 |
| | | Expr1032893 |
| | | Expr1145556 |
| | | Expr2017833 |
| | | Expr2035969 |
| | Drives_construct (21) |
| | Construct_product (21) |
| | Microarray_results (42) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_CoreEnriched |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:tunicamycin_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated |
| | | WBPaper00056586:kri-1(ok1251)_downregulated |
| | | WBPaper00056586:mpk-2(ok219)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057140:pptr-1(tm3103)_downregulated |
| | | WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets |
| | | WBPaper00057162:meg-3_meg-4_downregulated_sRNA |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059203:CAR-1_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RIA |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061527:srj-42-srw-113 |
| | | WBPaper00061651:IL2_DV_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064156:lipl-4(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065841:25_0 |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065841:140_0 |
| | | cgc4489_group_18 |
| | | cgc4489_group_23 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045015:acs-3(ft5)_downregulated |
| | | WBPaper00045015:nhr-25(RNAi)_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | Interaction (92) |
| | Anatomy_function | WBbtf0572 |
| | | WBbtf0573 |
| | | WBbtf0574 |
| | | WBbtf0575 |
| Map_info | Map | III | Position | -3.78592 | Error | 0.004728 |
| | Well_ordered |
| | Positive | Positive_clone | C30D11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 862 |
| | | | 1079 |
| | | | 2799 |
| | | | 3603 |
| | | | 4091 |
| | | | 4458 |
| Reference (73) |
| Remark | being swapped with mpk-1 at -4.05. was -3.93 [jah/sdm 5/99] |
| | klp-1 is the same gene as unc-103 and was therefore merged with this gene |
| Method | Gene |
