WormBase Tree Display for Gene: WBGene00006868

WBGene00006868 SMap: S_parent: Sequence: M03A1
  Identity: Version: 1
    Name: CGC_name: vab-1 Person_evidence: WBPerson261
      Sequence_name: M03A1.1
      Molecular_name: M03A1.1
        M03A1.1.1
        CE25060
      Other_name: CELE_M03A1.1 Accession_evidence: NDB BX284602
      Public_name: vab-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vab
    Reference_allele: WBVar00142901
    Allele (418)
    Legacy_information: e2 : notched head variable dystrophy of ventral cephalic region especially in L1; penetrance < 70%. ES3/0 ME3. NA8 (e1063 : penetrance 35%; e2027spo : penetrance > 90%).
      See also e2, e116, e118, e200, e699, e721, e1063, e2027
      [C.elegansII] e2 : notched head, variable dystrophy of ventral cephalic region, especially in L1; penetrance < 70%. ES3/0 ME3. OA>10: e1063 (penetrance 35%), e2027spo (penetrance > 90%), e699 etc. [Brenner 1974; Lewis and Hodgkin 1979; CB; CZ]
    Strain (24)
    RNASeq_FPKM (74)
    GO_annotation (38)
    Ortholog: WBGene00065095 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00034210 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00155867 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00125246 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00160030 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00154546 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00150969 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00149052 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00153659 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00145178 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00145179 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00142562 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00125977 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00179585 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00132909 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00127889 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00137154 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00053716 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00078108 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00055694 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00057412 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00056596 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00056595 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00069568 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00052702 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00178261 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00146827 Caenorhabditis brenneri From_analysis: Inparanoid_8
            WormBase-Compara
      CBOVI.g7045 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g2291 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g730 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g348 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g12697 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g27473 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g7543 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g2978 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g4659 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g10177 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00215.g7198 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_00875.g14695 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_08193.g21354 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-vab-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_II.g4511 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g15081 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00541.g12614 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00541.g12615 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_06765 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_06766 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_004460 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g11900 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g16329 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20228920 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g4270 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00248125 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00114883 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00285349 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0025936 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-990415-58 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-990415-60 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
      ZFIN:ZDB-GENE-990415-61 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-990415-62 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-990415-63 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-990415-65 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030826-6 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-001207-7 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            PhylomeDB
      ZFIN:ZDB-GENE-050522-415 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-070713-2 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
      ZFIN:ZDB-GENE-030131-3745 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-030219-187 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-100922-51 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-010724-10 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-090311-43 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:3386 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:3385 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:3387 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:3388 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:3389 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:3390 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:3391 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:3392 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:3393 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:3394 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:3395 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:3396 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:19987 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:19296 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:107381 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:95278 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:99612 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:98277 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:99654 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:108034 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:95276 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:109378 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:99611 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:104770 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:104757 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1096338 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:3586824 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:1096337 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:2556 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:1304614 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:68389 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:708543 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
      RGD:620831 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:70957 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:1305602 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:1562679 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:1306163 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:1304680 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:1564232 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:1560587 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:1307204 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:1583193 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
    Paralog (69)
    Structured_description: Concise_description: vab-1 encodes an ephrin receptor; during development, vab-1 activity is required for neural and epithelial morphogenesis as well as for proper axon targeting and neuronal cell migration; in addition, VAB-1 functions as a major sperm protein receptor in a sperm-sensing control mechanism that regulates oocyte meiotic maturation; VAB-1::GFP reporters are expressed in neuronal cells and in oocytes and sheath cells of the proximal gonad. Paper_evidence: WBPaper00003020
            WBPaper00003843
            WBPaper00005670
            WBPaper00027013
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Feb 2007 00:00:00
      Automated_description: Enables ephrin receptor activity and protein domain specific binding activity. Involved in several processes, including cell development; embryonic morphogenesis; and regulation of axon guidance. Located in axon and plasma membrane. Expressed in several structures, including hypodermal cell; neuroblasts; neurons; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; aortic dissection; cataract 6 multiple types; and gastrointestinal system cancer (multiple). Is an ortholog of several human genes including EPHB1 (EPH receptor B1); EPHB2 (EPH receptor B2); and EPHB3 (EPH receptor B3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (14)
  Molecular_info: Corresponding_CDS: M03A1.1
    Corresponding_CDS_history: M03A1.1b:wp274
    Corresponding_transcript: M03A1.1.1
    Other_sequence (11)
    Associated_feature (54)
  Experimental_info: RNAi_result (27)
    Expr_pattern (16)
    Drives_construct: WBCnstr00000707
      WBCnstr00006419
      WBCnstr00009616
      WBCnstr00018076
      WBCnstr00034120
      WBCnstr00042438
    Construct_product (15)
    Antibody: WBAntibody00000876
      WBAntibody00001049
      WBAntibody00001576
      WBAntibody00002037
      WBAntibody00002313
    Microarray_results (28)
    Expression_cluster (158)
    Interaction (248)
    Anatomy_function: WBbtf0217
      WBbtf0220
    WBProcess: WBbiopr:00000001
      WBbiopr:00000068
      WBbiopr:00000120
  Map_info: Map: II Position: -3.85469 Error: 0.013028
    Well_ordered
    Positive: Inside_rearr: mDf14
        mDf15
      Positive_clone: M03A1 Person_evidence: WBPerson105
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 266
      Multi_point: 48
        881
        882
        1880
        4031
        4032
      Pos_neg_data (12)
  Reference (154)
  Method: Gene